The interactive role of cannabinoid and vanilloid systems in hippocampal synaptic plasticity in rats

Tahmasebi, Lida; Komaki‬, Alireza; Karamian, Ruhollah; Shahidi, Siamak; Sarihi, Abdolrahman; Salehi, Iraj; Nikkhah, Ali

doi:10.1016/j.ejphar.2015.03.063

Cited by 34 publications

(5 citation statements)

References 60 publications

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“…Moreover, the recovering effects of SR, like the effects of OL, were attenuated by the TRPV1 antagonist CZ, and the antirecovering effects of CZ against OL were further counteracted by SR, which may reflect the mutually controlled activation of the ECB and TRPV1 systems in memory‐related behavioural plasticity. 109 , 110 , 111 Although the detailed mechanisms underlying the discrepancy in the efficacy of CB1/TRPV1 ligands between the anxiety‐ and working memory impairment‐related behaviours remain elusive, the differences in the relevant brain regions, 112 , 113 , 114 , 115 along with polymodal regulation of synaptic plasticity involved in the two neurotransmitter systems, 116 , 117 seemed to contribute, and this may be controlled subtly at the epigenetic level.…”

Section: Discussionmentioning

confidence: 99%

Interrelated involvement of the endocannabinoid/endovanilloid (TRPV1) systems and epigenetic processes in anxiety‐ and working memory impairment‐related behavioural effects of nicotine as a stressor

Hayase

2024

Addiction Biology

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The addictive use of nicotine contained in tobacco is associated with stressor‐like emotional and cognitive effects such as anxiety and working memory impairment, and the involvement of epigenetic mechanisms such as histone acetylation has recently been reported. Although the precise nature of behavioural plasticity remains unclear, both anxiogenic‐ and working memory impairment‐like effects were observed in the present experimental model of mice treated with repeated subcutaneous nicotine and/or immobilization stress, and these effects were commonly attenuated by the histone deacetylase (HDAC) inhibitors that induce histone acetylation. Such HDAC inhibitor‐induced resilience was mimicked by ligands for the endocannabinoid (ECB) system, a neurotransmitter system that is closely associated with nicotine‐induced addiction‐related behaviours: the anxiogenic‐like effects were mitigated by the cannabinoid type 1 (CB1) agonist arachidonylcyclopropylamide (ACPA), whereas the working memory impairment‐like effects were mitigated by the CB1 antagonist SR 141716A. Moreover, the effects of the HDAC inhibitors were also mimicked by ligands for the endovanilloid (transient receptor potential vanilloid 1 [TRPV1]) system, a system that shares common characteristics with the ECB system: the anxiogenic‐like effects were mitigated by the TRPV1 antagonist capsazepine, whereas the working memory impairment‐like effects were mitigated by the TRPV1 agonist olvanil. Notably, the HDAC inhibitor‐induced anxiolytic‐like effects were attenuated by SR 141716A, which were further counteracted by capsazepine, whereas the working memory improvement‐like effects were attenuated by capsazepine, which were further counteracted by SR 141716A. These results suggest the contribution of interrelated control of the ECB/TRPV1 systems and epigenetic processes such as histone acetylation to novel therapeutic approaches.

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Section: Discussionmentioning

confidence: 99%

Interrelated involvement of the endocannabinoid/endovanilloid (TRPV1) systems and epigenetic processes in anxiety‐ and working memory impairment‐related behavioural effects of nicotine as a stressor

Hayase

2024

Addiction Biology

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“…The fEPSP and PS were recorded 5, 30, and 60 min following the HFS for determining the alterations in the synaptic response of DG neurons. For each time point, 10 continuous evoked responses were averaged at a stimulus interval of 10 s. 47 , 48 , 49 , 50 …”

Section: Methodsmentioning

confidence: 99%

“…Input-output current profiles were achieved through the stimulation of the PP for determining the stimulus intensity for each rat (80% maximal population spike) (Figure 4). Single biphasic For each time point, 10 continuous evoked responses were averaged at a stimulus interval of 10 s. [47][48][49][50] The stimuli parameters were defined in homemade software followed by sending through a data acquisition board connected to a constant current isolator unit (A365 WPI) before to the PP using the stimulus electrodes. A preamplifier was employed to pass the induced field potential response from the DG and followed by amplification (1000×) (Differential amplifier DAM 80 WPI), and filtration (bandpass 1 Hz to 3 kHz).…”

Section: The Surgical Procedure Electrophysiological Recording and Lt...mentioning

confidence: 99%

The effects of carvacrol and p‐cymene on Aβ_1‐42‐induced long‐term potentiation deficit in male rats

Kazemi,

Safari,

Komaki

et al. 2023

CNS Neurosci Ther

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AimsAlzheimer's disease (AD) is the most common type of dementia in which oxidative stress plays an important role. In this disease, learning and memory and the cellular mechanism associated with it, long‐term potentiation (LTP), are impaired. Considering the beneficial effects of carvacrol (CAR) and p‐cymene against AD, their effect was assessed on in vivo hippocampal LTP in the perforant pathway (PP)‐dentate gyrus (DG) pathway in an Aβ1‐42‐induced rat model of AD.MethodsMale Wistar rats were randomly assigned to five groups: sham: intracerebroventricular (ICV) injection of phosphate‐buffered saline, Aβ: ICV Aβ1‐42 injections, Aβ + CAR (50 mg/kg), Aβ + p‐cymene (50 mg/kg), and Aβ + CAR + p‐cymene. Administration of CAR and p‐cymene was done by gavage daily 4 weeks before and 4 weeks after the Aβ injection. The population spike (PS) amplitude and field excitatory postsynaptic potentials (fEPSP) slope were determined in DG against the applied stimulation to the PP.ResultsAβ‐treated rats exhibited impaired LTP induction in the PP‐DG synapses, resulting in significant reduction in both fEPSP slope and PS amplitude compared to the sham animals. Aβ‐treated rats consumed either CAR or p‐cymene separately (but not their combination), and showed an enhancement in fEPSP slope and PS amplitude of the DG granular cells.ConclusionsThese data indicate that CAR or p‐cymene can ameliorate Aβ‐associated changes in synaptic plasticity. Surprisingly, the combination of CAR and p‐cymene did not yield the same effect, suggesting a potential interaction between the two substances.

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“…PS and EPSP were recorded 60 min following HFS for determining the DG neurons’ synaptic responses. At all-time points, 10 continuous evoked responses were averaged at stimulus intervals of 10 s [ 38 , 39 ].…”

Section: Methodsmentioning

confidence: 99%

Underlying mechanisms of long-term potentiation during the inhibition of the cannabinoid CB1 and GABAB receptors in the dentate gyrus of hippocampus

et al. 2023

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Background The release of various neurotransmitters and thereby the excitability of neuronal circuits are regulated by the endocannabinoid system in an activity-dependent manner. Hippocampal long-term potentiation (LTP) is augmented in cannabinoid type 1 (CB1) receptor-deficient mice. CB1 receptors exist on GABAergic axon terminals in the hippocampus. In our previous work, we showed that CB1 antagonists increased the population spike (PS) amplitude, field excitatory post-synaptic potential (fEPSP), and the LTP induction in the dentate gyrus (DG) of the rat hippocampus while the GABAB antagonist decreased these parameters. Determining the underlying mechanisms of the pre- and/or postsynaptic locus of LTP expression is of great importance. In this study, we investigated whether LTP alteration acutely caused by CB1 and GABAB receptor antagonists (AM251 and CGP55845, respectively) happens at the postsynaptic or presynaptic regions, or at both. Therefore, the paired-pulse ratio (PPR) was assessed prior to and following the LTP induction in the studied groups. Methods Male Wistar rats were randomly assigned to the groups of control, AM251, CGP55845, CGP55845 + AM251. A high-frequency stimulation (HFS) of the perforant path (PP) was used to induce LTP in the DG region. Results Statistical analysis revealed that AM251 produced significant increase in excitatory postsynaptic potential (EPSP) slope and amplitude of PS. Conversely, administration of CGP55845 produced decrease in slope of EPSP. The current results indicated that the PPR was not influenced by LTP induction in the presence of AM251 or CGP55845 either alone or their combination. Conclusions It can be concluded that the site causing LTP expression is, at least in part, the postsynaptic site because PPR was not influenced by LTP induction in the presence of AM251 or CGP55845 either alone or their combination.

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The interactive role of cannabinoid and vanilloid systems in hippocampal synaptic plasticity in rats

Cited by 34 publications

References 60 publications

Interrelated involvement of the endocannabinoid/endovanilloid (TRPV1) systems and epigenetic processes in anxiety‐ and working memory impairment‐related behavioural effects of nicotine as a stressor

Interrelated involvement of the endocannabinoid/endovanilloid (TRPV1) systems and epigenetic processes in anxiety‐ and working memory impairment‐related behavioural effects of nicotine as a stressor

The effects of carvacrol and p‐cymene on Aβ_1‐42‐induced long‐term potentiation deficit in male rats

Underlying mechanisms of long-term potentiation during the inhibition of the cannabinoid CB1 and GABAB receptors in the dentate gyrus of hippocampus

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The interactive role of cannabinoid and vanilloid systems in hippocampal synaptic plasticity in rats

Cited by 34 publications

References 60 publications

Interrelated involvement of the endocannabinoid/endovanilloid (TRPV1) systems and epigenetic processes in anxiety‐ and working memory impairment‐related behavioural effects of nicotine as a stressor

Interrelated involvement of the endocannabinoid/endovanilloid (TRPV1) systems and epigenetic processes in anxiety‐ and working memory impairment‐related behavioural effects of nicotine as a stressor

The effects of carvacrol and p‐cymene on Aβ1‐42‐induced long‐term potentiation deficit in male rats

Underlying mechanisms of long-term potentiation during the inhibition of the cannabinoid CB1 and GABAB receptors in the dentate gyrus of hippocampus

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The effects of carvacrol and p‐cymene on Aβ_1‐42‐induced long‐term potentiation deficit in male rats