The interactions of polyphenols with Fe and their application in Fenton/Fenton-like reactions

Pan, Yuwei; Qin, Rui; Hou, Minhui; Xue, Jinkai; Zhou, Minghua; Xu, Lijie; Zhang, Ying

doi:10.1016/j.seppur.2022.121831

Cited by 76 publications

(27 citation statements)

References 206 publications

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“…When the ortho-dihydroxyl moieties are present, the chelating ability increases. This is in line with polyphenols being able to stabilize Fe(III) more than Fe(II), the binding of polyphenols to Fe(II) reduces the reduction potential of iron, and Fe(II)-polyphenol complexes can be rapidly oxidized to Fe(III)-polyphenolic complexes [ 146 ]. Through a Fenton’s-reaction-based system, releasing ultra-weak chemiluminescence, composed by Fe 2+ , ethylene glycol-bis (β-aminoethyl ether)-N,N,N′,N′,-tetraacetic acid (EGTA), and hydrogen peroxide, the anti- and pro-oxidant activities of different polyphenols (5–50 µM) were investigated, and chemical features such as the presence of catechol or methoxyphenol appeared to be able to effectively scavenge hydroxyl radicals, thus exerting antioxidant activity, and to regenerate, acting as a pro-oxidant, Fe(II), by the reduction of Fe(III) [ 147 ].…”

Section: Polyphenols Vs Neurodegenerative Diseasementioning

confidence: 82%

Neuro-Nutraceutical Polyphenols: How Far Are We?

et al. 2023

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The brain, composed of billions of neurons, is a complex network of interacting dynamical systems controlling all body functions. Neurons are the building blocks of the nervous system and their impairment of their functions could result in neurodegenerative disorders. Accumulating evidence shows an increase of brain-affecting disorders, still today characterized by poor therapeutic options. There is a strong urgency to find new alternative strategies to prevent progressive neuronal loss. Polyphenols, a wide family of plant compounds with an equally wide range of biological activities, are suitable candidates to counteract chronic degenerative disease in the central nervous system. Herein, we will review their role in human healthcare and highlight their: antioxidant activities in reactive oxygen species-producing neurodegenerative pathologies; putative role as anti-acetylcholinesterase inhibitors; and protective activity in Alzheimer’s disease by preventing Aβ aggregation and tau hyperphosphorylation. Moreover, the pathology of these multifactorial diseases is also characterized by metal dyshomeostasis, specifically copper (Cu), zinc (Zn), and iron (Fe), most important for cellular function. In this scenario, polyphenols’ action as natural chelators is also discussed. Furthermore, the critical importance of the role exerted by polyphenols on microbiota is assumed, since there is a growing body of evidence for the role of the intestinal microbiota in the gut–brain axis, giving new opportunities to study molecular mechanisms and to find novel strategies in neurological diseases.

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Section: Polyphenols Vs Neurodegenerative Diseasementioning

confidence: 82%

Neuro-Nutraceutical Polyphenols: How Far Are We?

et al. 2023

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“…Furthermore, they possess an adjacent hydroxyl group in ring A in their structure. This feature, according to Pan et al (2022), enhances the chelating potential of these compounds as it has been demonstrated to increase their chelating capacity.…”

Section: Principal Component Analysis (Pca)mentioning

confidence: 97%

Phenolic, volatile compounds, antioxidant, and preservative activity of Argentinian Kabuli chickpea husk extract

Camiletti,

Bergesse,

Prieto

et al. 2023

J Americ Oil Chem Soc

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The objective of this study was to analyze the chemical composition and antioxidant activity of a chickpea husk polyphenol extract (CPE) obtained from Argentinian Kabuli chickpea and to evaluate its antioxidant effect on the chemical quality of sunflower oil. The polyphenol composition of CPE was analyzed by HPLC–ESI‐MS/MS. Antioxidant activity was evaluated by DPPH•, FRAP, ABTS•+, and chelating activity in ferrous ion tests. An accelerated oxidation test in sunflower oil was carried out by applying 0.01, 0.02, and 0.05% p/p CPE and comparing it with BHT (0.02%). Peroxide value, conjugated dienes, and volatile compounds were determined on sunflower oil samples. Twelve polyphenols were identified in the chickpea extract. The CPE showed in vitro antioxidant activity. The lowest doses (0.01% and 0.02%) protected sunflower oil more efficiently against oxidative deterioration than the higher level (0.05%). Chickpea husk extract has a good antioxidant effect on sunflower oil, which helps to preserve the quality properties of this product.

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“…In the case of caffeic acid, it chelated with iron and the complexes they formed effectively prevent hydroxyl radical formation induced by the Fenton reaction, which is determined by 2‐deoxyribose oxidative degradation and DMPO hydroxylation. Its antioxidant effects were enhanced in the lower pH and hydrophobic environment (Pan et al., 2022). Ellagic acid, a polyphenol abundant in many berries and pomegranates, restrains free radical formation in vitro by chelation with iron (Luana et al., 2017).…”

Section: Polyphenols Regulate Iron For Health Functionmentioning

confidence: 99%

Food‐borne polyphenols: A biocompatible anchor recuperating iron homeostasis

Feng

Zheng

et al. 2023

Food Frontiers

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Food‐borne polyphenols have long contributed to human health via multifaceted mechanisms, while emerged studies especially those published in recent 10 years have witnessed the close relevance between the bioactivity of polyphenols with iron homeostasis. Polyphenols are involved in various physiological processes of iron and manifest with multidirectional regulative effects. The diversiform polyphenols–iron interactions have extended the cognition of various disorders and diseases. This review aims to present a comprehensive scope of polyphenols–iron interactions, and the structural property, biological effects, and molecular mechanism of polyphenols on iron homeostasis were systematically illustrated, categorized, exemplified, and discussed. Multiple related disorders and diseases were focused on, and the specific polyphenols–iron interactions were elucidated during the processes of pathogenesis, development, intervention, and treatment. Present shortages such as bidirectional effects, unclear mechanism, clinical challenges, and extraction efficiency of polyphenols were also analyzed, and some innovative techniques adopted for polyphenols–iron‐based systems or therapies explorations were discussed, inspiring future perspectives for the understandings, exploitations, and correlations of both iron homeostasis and polyphenols. This review brings the polyphenols–iron interactions on the stage, telling the full story of how polyphenols anchor iron to achieve beneficial bioactivities, enlightening ideas for polyphenols–iron interactions‐based understanding of diseases, and illumining strategies for polyphenols as dietary adjuvant or future therapeutic agents for iron‐related physiological abnormality.

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The interactions of polyphenols with Fe and their application in Fenton/Fenton-like reactions

Cited by 76 publications

References 206 publications

Neuro-Nutraceutical Polyphenols: How Far Are We?

Neuro-Nutraceutical Polyphenols: How Far Are We?

Phenolic, volatile compounds, antioxidant, and preservative activity of Argentinian Kabuli chickpea husk extract

Food‐borne polyphenols: A biocompatible anchor recuperating iron homeostasis

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