The interaction studies of novel imine ligands and palladium(II) complexes with DNA and BSA for drug delivery application: The anti-cancer activity and molecular docking evaluation

Karami, Kazem; Mehvari, Fariba; Ramezanzade, Vahid; Zakariazadeh, Mostafa; Kharaziha, Mahshid; Ramezanpour, Azar

doi:10.1016/j.molliq.2022.119493

Cited by 16 publications

(1 citation statement)

References 72 publications

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“…[52][53][54] Recent advancements in drug delivery have been spurred by the design flexibility of COFs. [55,56] Although a wide range of drug carriers like micelles, [57] nanoparticles (NPs), [58] liposomes, [59] polymeric networks [60] have been tested, COFs have exhibited reliable encapsulation and drug release, due to their metal ion free structure and good biocompatibility. [61] Regardless of the capability of micellesbased DDS to solubilize hydrophobic or poor-water soluble drug molecules within their core, their low stability could be considered as their fundamental restriction in DDS, in particular during environmental changes.…”

Section: Introductionmentioning

confidence: 99%

A panoramic perspective of recent progress in 2D and 3D covalent organic frameworks for drug delivery

Mehvari,

Ramezanzade,

Asadi

et al. 2024

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The development of efficient drug delivery systems is essential for improving the efficacy and safety of cancer drugs, particularly for aggressive and difficult‐to‐treat cancers. Covalent organic frameworks (COFs) are emerging as innovative porous nanomaterials in drug delivery systems (DDS), due to their unique properties, including the metal‐free organic skeleton, predetermined structures and pore geometries, high porosity, large surface area, facile surface modification potential, and good biocompatibility. These characteristics make COFs excellent candidates for improving drug delivery by enhancing drug loading capacity and enabling precise encapsulation. This review emphasizes the importance of donor‐acceptor‐based COFs, which provide channels for charge transportation, and we also explore how the π‐conjugated skeleton of COFs enhances its long‐acting fluorescent properties and facilitates drug uptake via cell endocytosis. While this review primarily focuses on recent advancements in COF‐based targeted DDS, it also acknowledges the challenges posed by the diverse pore geometries in porous materials and discusses potential solutions. Further, it underlines the potential of developing future drug carriers that can successfully and specifically target cancer cells, improving treatment efficiency while reducing adverse side effects.

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Section: Introductionmentioning

confidence: 99%

A panoramic perspective of recent progress in 2D and 3D covalent organic frameworks for drug delivery

Mehvari,

Ramezanzade,

Asadi

et al. 2024

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The influence of electronic effects on the substitution reactions of N,N′-donor cis-palladium(II) complexes with bidentate (pyridin-2-yl)methyl-aniline ligands

Mjwara,

Papo,

Sithebe

2023

Reac Kinet Mech Cat

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The substitution behaviour of bidentate N,N′-donor (pyridin-2-yl)methyl-aniline chelates with different substituents on the mononuclear Pd(II) complexes was investigated. The complexes were synthesized and characterized using 1H NMR, 13C NMR, FTIR, LC–MS, and elemental analysis. The study explored the kinetics and mechanistic behaviour of N,N′-pyridyl Pd(II) complexes, viz. dichloro-(N-((pyridin-2-yl)methyl)aniline)palladium(II) (PdL1), dichloro-(4-fluoro-N-((pyridin-2-yl)methyl)aniline)-palladium(II) (PdL2), dichloro-(4-methoxy-N-((pyridin-2-yl)methyl)aniline)-palladium(II) (PdL3) and dichloro-(4-ethyl-N-((pyridin-2-yl)methyl)aniline)-palladium(II) (PdL4). The effect of concentration and temperature on substitution behaviour of coordinated chloride ligands by three bio-relevant thiourea nucleophiles, viz. thiourea (TU), N,N′-dimethylthiourea (DMTU) and N,N,N′,N′-tetramethylthiourea (TMTU), of different steric demands was studied in a 0.1 M (LiCl) solution of ultra-pure water under pseudo-first order conditions using standard Stopped-Flow and UV–Visible spectrophotometric techniques. The substitution of the chloride ligands from the Pd(II) metal by thiourea nucleophiles was a two-step reaction, where the chloride trans to the pyridine ligand was substituted first due to the strong trans effect on the pyridine ring compared to the amine group. The rate of substitution of the chloride by thiourea nucleophiles increased with the presence of an electron-withdrawing substituent and decreased when an electron-donating group was attached to the para position of the phenyl moiety. The negative activation entropies and positive activation enthalpy for all the substitution reactions support an associative mode of substitution mechanism.

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Synthesis, crystal structures and CT-DNA/BSA binding of Cd(II) and Mn(II) complexes with 5-hydroxypyrazine-2-carboxylic acid as a ligand

Yang,

Wang,

et al. 2024

Transit Met Chem

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The interaction studies of novel imine ligands and palladium(II) complexes with DNA and BSA for drug delivery application: The anti-cancer activity and molecular docking evaluation

Cited by 16 publications

References 72 publications

A panoramic perspective of recent progress in 2D and 3D covalent organic frameworks for drug delivery

A panoramic perspective of recent progress in 2D and 3D covalent organic frameworks for drug delivery

The influence of electronic effects on the substitution reactions of N,N′-donor cis-palladium(II) complexes with bidentate (pyridin-2-yl)methyl-aniline ligands

Synthesis, crystal structures and CT-DNA/BSA binding of Cd(II) and Mn(II) complexes with 5-hydroxypyrazine-2-carboxylic acid as a ligand

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