The interaction of vasoactive substances during exercise modulates platelet aggregation in hypertension and coronary artery disease

Petidis, Konstantinos; Δούμα, Στέλλα; Doumas, Michael; Basagiannis, I.; Vogiatzis, Konstantinos; Zamboulis, Chrysanthos

doi:10.1186/1471-2261-8-11

Cited by 33 publications

(34 citation statements)

References 36 publications

(29 reference statements)

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“…The findings of our investigation are consistent with evidence in the literature linking sympathetic function with diverse systemic and multiorgan derangements, including hypertension [46], myocardial ischemia [47], congestive heart failure [48], cardiac tachyarrhythmias [49], sudden cardiac mortality [50], abnormal renal natriuresis [51], enhanced platelet aggregation [52] and impaired immune function [53]. Sympathetically mediated neurogenic cardiopulmonary complications have been related to adverse outcomes following SAH [54], and sympathetic activity has been connected to increased inflammation and enhanced thrombosis [7,8], the markers of which predict detrimental outcomes in patients with SAH [18,20].…”

Section: Discussionsupporting

confidence: 78%

Cerebrospinal Fluid Catecholamine Levels as Predictors of Outcome in Subarachnoid Hemorrhage

Moussouttas

Huynh

Khoury³

et al. 2012

Cerebrovasc Dis

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Objective: Subarachnoid hemorrhage (SAH) is associated with marked sympathetic activation at the time of ictus. The purpose of this study is to determine whether early central catecholamine levels measured from cerebrospinal fluid (CSF) relate to outcome in patients with SAH. Methods: Observational study of consecutive SAH grade 3–5 patients who underwent ventriculostomy placement, but did not undergo open craniotomy for aneurysm obliteration. CSF samples were obtained during the first 48 h following symptom onset and assayed for catecholamine levels. Statistical analyses were performed to determine whether the levels predicted mortality by day 15 or mortality/disability by day 30. Results: For the 102 patients included, mean age was 58, and 73% were female – 21% experienced day-15 mortality, and 32% experienced mortality/disability by day 30. Early mortality was related to Hunt-Hess (H/H) grade (p < 0.001), neurogenic cardiomyopathy (NC) (p = 0.003), cerebral infarction (p = 0.001), elevated intracranial pressure (ICP) (p = 0.029), epinephrine (EPI) level (p = 0.002) and norepinephrine/3,4-dihydroxyphenylglycol (NE/DHPG) ratio (p = 0.003). Mortality/disability was related to H/H grade (p < 0.001), NC (p = 0.018), infarction (p < 0.001), elevated ICP (p = 0.002), EPI (p = 0.004) and NE/DHPG (p = 0.014). Logistic regression identified age [OR 1.09 (95% CI 1.01–1.17)], H/H grade [9.52 (1.19–77)], infarction [10.87 (1.22–100)], ICP elevation [32.26 (2–500)], EPI [1.06 (1.01–1.10)], and (inversely) DHPG [0.99 (0.99–1.00)] as independent predictors of early mortality. For mortality/disability, H/H grade [OR 21.74 (95% CI 5.62–83)], ICP elevation [18.52 (1.93–166)], and EPI [1.05 (1.02–1.09)] emerged as independent predictors. Proportional-hazards analysis revealed age [HR 1.041 (95% CI 1.003–1.08)], H/H grade [6.9 (1.54–31.25)], NC [4.31 (1.5–12.35)], and EPI [1.032 (1.009–1.054)] independently predicted early mortality. Conclusions: CSF catecholamine levels are elevated in SAH patients who experience early mortality or disability. EPI may potentially serve as useful index of outcome in this population of patients with SAH.

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Section: Discussionsupporting

confidence: 78%

Cerebrospinal Fluid Catecholamine Levels as Predictors of Outcome in Subarachnoid Hemorrhage

Moussouttas

Huynh

Khoury³

et al. 2012

Cerebrovasc Dis

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“…The observation that AMPK, AMPK regulatory proteins, and eNOS are activated after a single bout of exercise suggests they may be a critical component of these signaling events. Second, aerobic-type exercise can cause a hypercoagulant state associated with increases in platelet count (33), plasma catecholamines, thromboxane A2, and endothelin-1 release (39). The activation of eNOS, and secondarily NO release from the endothelium, could represent a counterbalance that maintains hemostasis during such physical activity.…”

Section: Discussionmentioning

confidence: 99%

Acute exercise activates AMPK and eNOS in the mouse aorta

Cacicedo

Gauthier

LeBrasseur³

et al. 2011

American Journal of Physiology-Heart and Circulatory Physiology

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Exercise can prevent endothelial cell (EC) dysfunction and atherosclerosis even in the absence of improvements in plasma lipids. However, the mechanisms responsible for these effects are incompletely understood. In this study we examined in mice whether an acute bout of exercise activates enzymes that could prevent EC dysfunction, such as AMP-activated protein kinase (AMPK) and endothelial nitric oxide synthase (eNOS). We also examined whether exercise alters known regulators of these enzymes. C57BL/6 mice underwent a single bout of exhaustive treadmill exercise after which their aortas were analyzed for activation of AMPK, AMPK regulatory proteins, eNOS, and various enzymes that, like AMPK, activate eNOS. We found that such exercise acutely activates both AMPK and eNOS in the whole aorta and that the magnitude of these effects correlated with both the distance run and activation of the AMPK regulatory proteins silent information regulator-1 (SIRT1)-LKB1 and CaMKKβ. In contrast, Akt, PKA, PKG, and Src, other kinases known to activate eNOS, were unaffected. Immunohistochemical analysis revealed that AMPK and eNOS were both activated in the ECs of the aorta. This study provides the first evidence that an acute bout of exercise activates AMPK and eNOS in the endothelium of the aorta. The results also suggest that AMPK likely is the principal activator of eNOS in this setting and that its own activation may be mediated by both SIRT1-LKB1 and CaMKKβ.

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“…It has also been reported that fibrinogen follows a circadian rhythm similar to the blood pressure. 23 The importance of blood hemostasis and the role of physical activity and circadian rhythm inspired the present study to investigate the effect of acute training and circadian rhythm on the blood hemostasis in female athletes.…”

Section: The Effect Of Acute Training and Circadian Rhythm On Blood Hmentioning

confidence: 99%

The Effect of Acute Training and Circadian Rhythm on Blood Hemostasis in Female Athletes

Mahmoodinezhad¹,

Shakerian²,

Ghalavand³

et al. 2016

Int J Basic Sci Med

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Background: Circadian rhythm and physical activity are factors that influence the homeostasis of blood. This study aimed to investigate the effect of exhaustive exercise in the morning and evening on the blood hemostasis in female athletes. Methods: In the present quasi-experimental study, 30 female athletes aged 18-25 were selected by convenience sampling method and randomly divided into two groups (morning and afternoon exercises). The standard Bruce protocol test was used. In the present study, platelets, fibrinogen, and thromboplastin time were measured as indicators of blood coagulation before and after testing. Paired t-test and covariance analysis were used to analyze the measured indices and P ≤ 0.05 was considered significant. Results: An acute exhausting aerobic training session in both groups significantly increased platelet and fibrinogen levels, but a significant decrease was observed in thromboplastin time. Considering the training time, significant difference was observed in the blood thromboplastin time in the morning in comparison with the afternoon. Conclusion: According to the results of this study, the circadian rhythm and acute exhausting aerobic training are effective factors on the blood coagulation and a training session in the morning compared with the evening training has a greater effect on the blood coagulation.

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The interaction of vasoactive substances during exercise modulates platelet aggregation in hypertension and coronary artery disease

Abstract: Background: Acute vigorous exercise, associated with increased release of plasma catecholamines, transiently increases the risk of primary cardiac arrest. We tested the effect of acute submaximal exercise on vasoactive substances and their combined result on platelet function.

Cited by 33 publications

References 36 publications

Cerebrospinal Fluid Catecholamine Levels as Predictors of Outcome in Subarachnoid Hemorrhage

Cerebrospinal Fluid Catecholamine Levels as Predictors of Outcome in Subarachnoid Hemorrhage

Acute exercise activates AMPK and eNOS in the mouse aorta

The Effect of Acute Training and Circadian Rhythm on Blood Hemostasis in Female Athletes

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