“…Akin to surfactants that aggregate into micelles above the critical micellar concentration (CMC), hydrotropes self-associate above their minimum hydrotrope concentration (HMC) , and can reduce the surface tension of water . The hydrophobic portion of hydrotropes is either short alkyl groups or aromatic rings as opposed to long hydrocarbon chains in surfactants (C 16 –C 18 ), resulting in higher hydrophilic/lipophilic balance (HLB)a factor that accounts for the higher concentration of hydrotrope (μmolL –1 to mmolL –1 ) required for solubilization. ,,, Hydrotropes have been utilized, since their inception, to improve the water solubility of a wide range of organic compounds, namely, drugs and biochemicals. − They often improve the micellization property of surfactants through synergistic noncovalent interactions. − The differential solvent affinity of the constituent ions has been exploited for various extraction-related applications. − The dissolved solute can be precipitated and recovered effortlessly by diluting the hydrotropic solution. , …”