The interaction of social risk factors and HPA axis dysregulation in predicting emotional symptoms of five- and six-year-old children

Klitzing, Kai von; Perren, Sonja; Klein, Annette M.; Stadelmann, Stephanie; White, Lars O.; Groeben, Maureen; Holsboer‐Trachsler, Edith; Brand, Serge; Hatzinger, Martin

doi:10.1016/j.jpsychires.2011.12.004

Cited by 28 publications

(28 citation statements)

References 61 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consistent with other evidence (Badanes et al., ; von Klitzing et al., ; Ouellet‐Morin, Odgers et al., ), we found that when youth were exposed to harsh, nonresponsive parenting in early childhood as well as traumatic events in middle childhood, blunted cortisol reactivity was associated with elevated internalizing and externalizing problems. Consistent with a differential susceptibility framework (Belsky & Pluess, , ), however, blunted cortisol reactivity was associated with very low levels of internalizing problems among children who had not experienced any recent traumatic events.…”

Section: Discussionsupporting

confidence: 91%

“…Consistent with a diathesis-stress model, HPA axis reactivity is more strongly associated with child and adolescent problem behaviors when youth have had stressful relationships and experiences than when youth have been free of such stressors. The direction of this association varies across studies, however, with some work indicating that low levels of cortisol reactivity increase risk for emotional and behavioral problems (Badanes, Watamura, & Hankin, 2011;von Klitzing et al, 2012;Ouellet-Morin, Odgers et al, 2011) and other research finding that low levels of cortisol reactivity have buffering effects on children's mental health (von Klitzing et al, 2012;Saxbe et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Interactive effects of early and recent exposure to stressful contexts on cortisol reactivity in middle childhood

Jaffee

McFarquhar

Stevens

et al. 2014

Child Psychology Psychiatry

View full text Add to dashboard Cite

BackgroundGiven mixed findings as to whether stressful experiences and relationships are associated with increases or decreases in children's cortisol reactivity, we tested whether a child's developmental history of risk exposure explained variation in cortisol reactivity to an experimentally induced task. We also tested whether the relationship between cortisol reactivity and children's internalizing and externalizing problems varied as a function of their developmental history of stressful experiences and relationships.MethodParticipants included 400 children (M = 9.99 years, SD = 0.74 years) from the Children's Experiences and Development Study. Early risk exposure was measured by children's experiences of harsh, nonresponsive parenting at 3 years. Recent risk exposure was measured by children's exposure to traumatic events in the past year. Children's cortisol reactivity was measured in response to a social provocation task and parents and teachers described children's internalizing and externalizing problems.ResultsThe effect of recent exposure to traumatic events was partially dependent upon a child's early experiences of harsh, nonresponsive parenting: the more traumatic events children had recently experienced, the greater their cortisol reactivity if they had experienced lower (but not higher) levels of harsh, nonresponsive parenting at age 3. The lowest levels of cortisol reactivity were observed among children who had experienced the most traumatic events in the past year and higher (vs. lower) levels of harsh, nonresponsive parenting in early childhood. Among youth who experienced harsh, nonresponsive parent–child relationships in early childhood and later traumatic events, lower levels of cortisol reactivity were associated with higher levels of internalizing and externalizing problems.ConclusionsHypothalamic–pituitary–adrenal (HPA) axis reactivity to psychological stressors and the relationship between HPA axis reactivity and children's internalizing and externalizing problems vary as a function of a child's developmental history of exposure to stressful relationships and experiences.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Interactive effects of early and recent exposure to stressful contexts on cortisol reactivity in middle childhood

Jaffee

McFarquhar

Stevens

et al. 2014

Child Psychology Psychiatry

View full text Add to dashboard Cite

show abstract

“…Given the linear nature of the suggested risk model, it may be possible to distinguish patients with single incidents from patients with repeat incidents with this parameter. Our findings further support the theory that psychosocial stressors can lead to a decreased threshold for a subsequent social stressor (12); patients with repeat aggressive or self-harming incidents showed not only higher numbers of psychosocial stressors than patients with single incidents but also higher numbers of clinical relational stressors.…”

Section: Discussionsupporting

confidence: 85%

Relational stressors as predictors for repeat aggressive and self-harming incidents in child and adolescent psychiatric inpatient settings

Ulke

Klein

Klitzing

2014

International Journal of Adolescent Medicine and Health

Self Cite

View full text Add to dashboard Cite

This study examined whether relational stressors such as psychosocial stressors, the therapist's absence and a change of therapist are associated with repeat aggressive or self-harming incidents in child and adolescent psychiatric inpatient care. The study data were derived from critical incident reports and chart reviews of 107 inpatients. In multinomial regression analysis, patients with repeat aggressive or self-harming incidents were compared with patients with single incidents. Results suggested that a higher number of psychosocial stressors and a change of therapist, but not the therapist's absence are predictors for repeat aggressive and self-harming incidents. There was a high prevalence of therapist's absence during both, single and repeat, incidents. Repeat aggressive incidents were common in male children and adolescents with disruptive behavior disorders. Repeat self-harming incidents were common in adolescent females with trauma-related disorders. Patients with repeat aggressive or self-harming incidents had a higher number of abnormal intrafamilial relationships and acute life events than patients with single incidents. Interventions to reduce a change of therapist should in particular target children and adolescents with a higher number of psychosocial stressors and/or a known history of traumatic relational experiences. After a first incident, patients should have a psychosocial assessment to evaluate whether additional relational support is needed.

show abstract

“…Cortisol reactivity to a laboratory challenge has been found to be dysregulated in preschoolers with internalizing symptoms, particularly among girls 21 . One study used both cross-sectional and longitudinal analyses to evaluate the role of social and neuroendocrinological risk factors (e.g., cortisol) in the development of internalizing symptoms at preschool 22 . Both negative peer relations and family environments were concurrently associated with internalizing symptoms in preschoolers, with cortisol increases during a stressful task moderating the relationship between negative family environment and internalizing symptoms.…”

Section: Research On Preschool Internalizing Disordersmentioning

confidence: 99%

Depression and Anxiety in Preschoolers

Whalen

Sylvester

Luby

2017

Child and Adolescent Psychiatric Clinics of North America

101

View full text Add to dashboard Cite

Synopsis This article reviews recent empirical literature on the prevalence, correlates, assessment, and treatment of preschool-onset internalizing disorders. Major advances in the acceptance and recognition of both preschool-onset depression and anxiety have occurred over the past decade. This work has been greatly enhanced by the discovery of genetic, neural, and physiological indicators, which further validate these constellations of symptoms in young children. Despite this growth in research, much work still needs to be done to further elucidate the etiology, risk treatment and protective factors for preschool-onset internalizing disorders.

show abstract

The interaction of social risk factors and HPA axis dysregulation in predicting emotional symptoms of five- and six-year-old children

Cited by 28 publications

References 61 publications

Interactive effects of early and recent exposure to stressful contexts on cortisol reactivity in middle childhood

Interactive effects of early and recent exposure to stressful contexts on cortisol reactivity in middle childhood

Relational stressors as predictors for repeat aggressive and self-harming incidents in child and adolescent psychiatric inpatient settings

Depression and Anxiety in Preschoolers

Contact Info

Product

Resources

About