The interaction of platinum and anthrapyrazole antitumor drugs with mouse thymocytes studied by terbium fluorescence

Simpkins, Henry; Figliomeni, Maria L.; Rosen, Martin H.

doi:10.1016/s0005-2728(88)80088-4

Cited by 1 publication

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“…Similarities between spectroscopically silent Ca 2+ and versatile lanthanides have enabled the investigation of calcium-binding sites in cell membranes and calcium channels. 83,84 Significant differences are often seen within the lanthanide series due to the decrease in the ionic radius from 106 ppm to 86 ppm upon going from La 3+ to Yb 3+ . 84,85 In the absence of the ionophore A23187, at concentrations up to 400 mM, Yb 3+ , Tb 3+ , Eu 3+ , La 3+ , Sm 3+ and Gd 3+ were unable to mimic Ca 2+ in triggering K + -release.…”

Section: Methods Of Lanthanide Deliverymentioning

confidence: 99%

Lanthanide-based tools for the investigation of cellular environments

et al. 2018

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Biological probes constructed from lanthanides can provide a variety of readout signals, such as the luminescence of Eu(iii), Tb(iii), Yb(iii), Sm(iii) and Dy(iii), and the proton relaxation enhancement of Gd(iii) and Eu(ii). For numerous applications the intracellular delivery of the lanthanide probe is essential. Here, we review the methods for the intracellular delivery of non-targeted complexes (i.e. where the overall complex structure enhances cellular uptake), as well as complexes attached to a targeting unit (i.e. to a peptide or a small molecule) that facilitates delivery. The cellular applications of lanthanide-based supramolecules (dendrimers, metal organic frameworks) are covered briefly. Throughout, we emphasize the techniques that can confirm the intracellular localization of the lanthanides and those that enable the determination of the fate of the probes once inside the cell. Finally, we highlight methods that have not yet been applied in the context of lanthanide-based probes, but have been successful in the intracellular delivery of other metal-based probes.

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