The interaction of orthopoxviruses and interferon-treated cultured cells

Replication of Modified Vaccinia Virus Ankara in Primary Chicken Embryo Fibroblasts Requires Expression of the Interferon Resistance Gene E3L

“…The importance of the IFN system for the mediation of antipoxvirus activity in avian cells is well established. While vaccinia virus replication has been found to be relatively resistant to IFN activity in mammalian cells (40,56,68), pretreatment of CEF with chicken IFN appears to more efficiently inhibit the vaccinia virus life cycle (22,28). In our experiments monitoring vaccinia virus infection after IFN treatment, we found that CEF-adapted MVA was as susceptible to IFN as the wild-type vaccinia virus strains CVA and WR.…”