The interaction of chronic and acute glycemia with mortality in critically ill patients with diabetes*

Egi, Moritoki; Bellomo, Rinaldo; Stachowski, Edward; French, Craig; Hart, Graeme K; Taori, Gopal; Hegarty, Colin; Bailey, Michael

doi:10.1097/ccm.0b013e3181feb5ea

Cited by 187 publications

(138 citation statements)

References 32 publications

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“…Hyperglycemia and glucose variability seem to be unassociated with increased mortality rates in diabetic patients compared to nondiabetic patients [473][474][475]. Patients with diabetes and chronic hyperglycemia, end-stage renal failure, or medical versus surgical ICU patients may require higher blood glucose ranges [476,477].…”

Section: We Suggest the Use Of Arterial Blood Rather Than Capillary Bmentioning

confidence: 99%

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

et al. 2017

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Objective: To provide an update to "Surviving Sepsis Campaign Guidelines for Management of Sepsis and Septic Shock: 2012". Design:A consensus committee of 55 international experts representing 25 international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members attending the conference). A formal conflict-of-interest (COI) policy was developed at the onset of the process and enforced throughout. A stand-alone meeting was held for all panel members in December 2015. Teleconferences and electronic-based discussion among subgroups and among the entire committee served as an integral part of the development. Methods:The panel consisted of five sections: hemodynamics, infection, adjunctive therapies, metabolic, and ventilation. Population, intervention, comparison, and outcomes (PICO) questions were reviewed and updated as needed, and evidence profiles were generated. Each subgroup generated a list of questions, searched for best available evidence, and then followed the principles of the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system to assess the quality of evidence from high to very low, and to formulate recommendations as strong or weak, or best practice statement when applicable.

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Section: We Suggest the Use Of Arterial Blood Rather Than Capillary Bmentioning

confidence: 99%

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

et al. 2017

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“…Egi et al published a very intriguing investigation in 2011 that analyzed the outcomes of 415 diabetics admitted to two Australian ICUs [45]. All had measurement of hemoglobin A1c (HgbA1c) within 3 months of hospitalization.…”

Section: Acute and Chronic Glycemiamentioning

confidence: 99%

Glycemic control in the critically ill: What have we learned since NICE-SUGAR?

Krinsley

2015

Hospital Practice

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Since publication of the Normoglycemia in Intensive Care Evaluation - Survival Using Glucose Algorithm Regulation trial in 2009, demonstrating increased 90-day mortality in a large cohort of critically ill patients treated with the intensive, rather than moderate blood glucose (BG) target, enthusiasm has dampened for 'tight glucose control' in intensive care units. Nevertheless, a burgeoning literature has clarified limitations of the interventional trials of intensive insulin therapy in the critically ill and explored key clinical aspects of glycemic control in this population. This review provides an overview of the last 6 years of research in this field. Topics include advances in understanding the domains of glycemic control - hyperglycemia, hypoglycemia and glucose variability; the role of diabetic status in modulating the relationship of these domains of control to mortality; the importance of premorbid glucose control in patients with diabetes; the central role that measurement frequency has in determining success in achieving desired BG control and, finally, new data exploring time in targeted BG range, a potentially 'unifying' metric.

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“…The physiological background for this apparent difference is unclear. Other observational studies have suggested that the optimal glycemic target in diabetics may depend on the pre-existing level of glycemic control, as reflected by the pre-admission HbA1c (20,21). From a physiological point of view, this appears more plausible, as patients may adapt to chronic hyperglycemia (22).…”

Section: Editorialmentioning

confidence: 99%

Acute severe illness in diabetes patients: is tolerating hyperglycemia beneficial?

Gunst¹,

Berghe²

2016

J. Thorac. Dis.

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The interaction of chronic and acute glycemia with mortality in critically ill patients with diabetes*

Cited by 187 publications

References 32 publications

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

Glycemic control in the critically ill: What have we learned since NICE-SUGAR?

Acute severe illness in diabetes patients: is tolerating hyperglycemia beneficial?

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