The Interaction between the Gut Microbiome and Bile Acids in Cardiometabolic Diseases

CALLENDER, CENGIZ; Attaye, Ilias; Nieuwdorp, Max

doi:10.3390/metabo12010065

Cited by 17 publications

(16 citation statements)

References 108 publications

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“…There is a strong biochemical relationship between BAs and gut microbiota. Some gut microbiota in healthy people can convert conjugated BAs into free BAs, and can transform BAs into secondary BAs with the help of bile salt hydrolase (BSH) and cholesterol 7-alpha hydroxy-lase (CYP7A1) [ 147 ], so as to reduce blood cholesterol by affecting the enterohepatic circulation of BAs [ 148 , 149 ]. Besides, the gut microbiota affects the metabolism of BAs by regulating the activity of BSH to reduce LDL cholesterol levels [ 150 ].…”

Section: The Role Of the Gut Microbiota In Health And Diseasesmentioning

confidence: 99%

“…It remains unclear how the gut microbiota and BAs profiles interact with each other and whether the interaction is associated with obesity [ 147 ]. Mice fed BAs exhibited obesity and a composition change in the obesity-associated gut microbiota, which is similar to high-fat diet-fed mice [ 216 , 217 ].…”

Section: The Gut Microbiota and Cardiovascular Risk Factorsmentioning

confidence: 99%

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The role of the gut microbiota in health and cardiovascular diseases

Wang

Zhang

et al. 2022

Mol Biomed

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The gut microbiota is critical to human health, such as digesting nutrients, forming the intestinal epithelial barrier, regulating immune function, producing vitamins and hormones, and producing metabolites to interact with the host. Meanwhile, increasing evidence indicates that the gut microbiota has a strong correlation with the occurrence, progression and treatment of cardiovascular diseases (CVDs). In patients with CVDs and corresponding risk factors, the composition and ratio of gut microbiota have significant differences compared with their healthy counterparts. Therefore, gut microbiota dysbiosis, gut microbiota-generated metabolites, and the related signaling pathway may serve as explanations for some of the mechanisms about the occurrence and development of CVDs. Several studies have also demonstrated that many traditional and latest therapeutic treatments of CVDs are associated with the gut microbiota and its generated metabolites and related signaling pathways. Given that information, we summarized the latest advances in the current research regarding the effect of gut microbiota on health, the main cardiovascular risk factors, and CVDs, highlighted the roles and mechanisms of several metabolites, and introduced corresponding promising treatments for CVDs regarding the gut microbiota. Therefore, this review mainly focuses on exploring the role of gut microbiota related metabolites and their therapeutic potential in CVDs, which may eventually provide better solutions in the development of therapeutic treatment as well as the prevention of CVDs.

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Section: The Role Of the Gut Microbiota In Health And Diseasesmentioning

confidence: 99%

Section: The Gut Microbiota and Cardiovascular Risk Factorsmentioning

confidence: 99%

The role of the gut microbiota in health and cardiovascular diseases

Wang

Zhang

et al. 2022

Mol Biomed

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“…The GM is a potential controller of wellness and disease. As demonstrated by experimental, clinical, and epidemiological evidence, a dysbiotic microbiota (i.e., a microbiota that deviates from the “eubiotic” status in terms of diversity and functionality [ 11 ]) is implicated in a range of diseases in adults, including inflammatory bowel disease [ 12 , 13 ], arthritis [ 14 ], cancer [ 15 ], neurological and neuropsychiatric disorders [ 16 ], cardiometabolic [ 17 ] and cardiovascular [ 18 ] disease, obesity [ 19 ], type 2 diabetes [ 20 , 21 , 22 ], and, as detailed below, infertility.…”

Section: Gut Microbiota: a New Player In Townmentioning

confidence: 99%

Endocrine-Disrupting Chemicals, Gut Microbiota, and Human (In)Fertility—It Is Time to Consider the Triad

Fabozzi

Rebuzzini

Cimadomo

et al. 2022

Cells

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The gut microbiota (GM) is a complex and dynamic population of microorganisms living in the human gastrointestinal tract that play an important role in human health and diseases. Recent evidence suggests a strong direct or indirect correlation between GM and both male and female fertility: on the one hand, GM is involved in the regulation of sex hormone levels and in the preservation of the blood–testis barrier integrity; on the other hand, a dysbiotic GM is linked to the onset of pro-inflammatory conditions such as endometriosis or PCOS, which are often associated with infertility. Exposure to endocrine-disrupting chemicals (EDCs) is one of the main causes of GM dysbiosis, with important consequences to the host health and potential transgenerational effects. This perspective article aims to show that the negative effects of EDCs on reproduction are in part due to a dysbiotic GM. We will highlight (i) the link between GM and male and female fertility; (ii) the mechanisms of interaction between EDCs and GM; and (iii) the importance of the maternal–fetal GM axis for offspring growth and development.

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“…An increasing number of clinical studies have suggested that the gut microbiota and microbial metabolites are significantly different between patients with CMD and normal subjects. 25 , 26 , 27 , 28 A recent study revealed microbiome and metabolome features of the CMD spectrum. Patients with CMD already exhibit microbiota changes such as reduced bacterial cell counts and loss of microbial function in the early stages of their metabolic disorders.…”

Section: Introductionmentioning

confidence: 99%

Dietary patterns and cardiometabolic health: Clinical evidence and mechanism

Wang

Liu

et al. 2023

MedComm

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For centuries, the search for nutritional interventions to underpin cardiovascular treatment and prevention guidelines has contributed to the rapid development of the field of dietary patterns and cardiometabolic disease (CMD). Numerous studies have demonstrated that healthy dietary patterns with emphasis on food-based recommendations are the gold standard for extending lifespan and reducing the risks of CMD and mortality. Healthy dietary patterns include various permutations of energy restriction, macronutrients, and food intake patterns such as calorie restriction, intermittent fasting, Mediterranean diet, plant-based diets, etc. Early implementation of healthy dietary patterns in patients with CMD is encouraged, but an understanding of the mechanisms by which these patterns trigger cardiometabolic benefits remains incomplete. Hence, this review examined several dietary patterns that may improve cardiometabolic health, including restrictive dietary patterns, regional dietary patterns, and diets based on controlled macronutrients and food groups, summarizing cutting-edge evidence and potential mechanisms for CMD prevention and treatment. Particularly, considering individual differences in responses to dietary composition and nutritional changes in organ tissue diversity, we highlighted the critical role of individual gut microbiota in the crosstalk between diet and CMD and recommend a more precise and dynamic nutritional strategy for CMD by developing dietary patterns based on individual gut microbiota profiles.

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The Interaction between the Gut Microbiome and Bile Acids in Cardiometabolic Diseases

Cited by 17 publications

References 108 publications

The role of the gut microbiota in health and cardiovascular diseases

The role of the gut microbiota in health and cardiovascular diseases

Endocrine-Disrupting Chemicals, Gut Microbiota, and Human (In)Fertility—It Is Time to Consider the Triad

Dietary patterns and cardiometabolic health: Clinical evidence and mechanism

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