The interaction between physical activity and sleep on cognitive function and brain beta-amyloid in older adults

Sewell, Kelsey R; Rainey‐Smith, Stephanie R.; Villemagne, Victor L.; Peiffer, Jeremiah J.; Sohrabi, Hamid R.; Taddei, Kevin; Ames, David; Doré, Vincent; Maruff, Paul; Laws, Simon M.; Masters, Colin L.; Rowe, Christopher C.; Martins, Ralph N.; Erickson, Kirk I.; Brown, Belinda M.

doi:10.1016/j.bbr.2022.114108

Cited by 11 publications

(10 citation statements)

References 41 publications

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“…Similarly, both those with poorer sleep efficiency (<74%) and better sleep efficiency (>85%) showed improvements in global cognition from pre‐ to post‐intervention. These results are consistent with previous research showing that physical activity may attenuate some of the negative impact of poor sleep on cognitive function 11,20,21 . Importantly, the current research extends previous findings by illustrating that despite a lack of exercise induced change in sleep efficiency (Table 2), exercise still had a positive influence on cognition in those with poorer baseline sleep efficiency.…”

Section: Discussionsupporting

confidence: 92%

“…Observational research indicates that sleep might moderate the association between physical activity and cognitive function 18,19 . Specifically, poor sleep may strengthen the association between physical activity and cognition 20,21 . However, randomised clinical trials with supervised exercise interventions have not yet reported whether sleep influences the efficacy of exercise‐induced cognitive change, or whether exercise influences the association between sleep and cognitive function 11 .…”

Section: Introductionmentioning

confidence: 99%

“…For the current analysis, we examined whether baseline sleep moderated the magnitude of exercise‐induced changes to cognition, and how the exercise intensity dose manipulation affected sleep pre‐ to post‐intervention. Based on Lambiase 20 and Sewell, 21 we hypothesised that poorer sleepers at baseline would show greater cognitive improvement from pre‐ to post‐intervention, compared to better sleepers. Moreover, given that exercise can improve sleep in older adults, but the dose parameters of this association are unclear, we aimed to compare the impact of moderate intensity and high intensity exercise on changes in subjective sleep from pre‐ to post‐intervention.…”

Section: Introductionmentioning

confidence: 99%

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The influence of baseline sleep on exercise‐induced cognitive change in cognitively unimpaired older adults: A randomised clinical trial

Sewell,

Rainey‐Smith,

Peiffer

et al. 2023

Int J Geriat Psychiatry

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ObjectivesObservational studies consistently demonstrate that physical activity is associated with elevated cognitive function, however, there remains significant heterogeneity in cognitive outcomes from randomized exercise interventions. Individual variation in sleep behaviours may be a source of variability in the effectiveness of exercise‐induced cognitive change, however this has not yet been investigated. The current study aimed to (1) investigate the influence of a 6‐month exercise intervention on sleep, assessed pre‐ and post‐intervention and, (2) investigate whether baseline sleep measures moderate exercise‐induced cognitive changes.MethodsWe utilised data from the Intense Physical Activity and Cognition (IPAC) study (n = 89), a 6‐month moderate intensity and high intensity exercise intervention, in cognitively unimpaired community‐dwelling older adults aged 60–80 (68.76 ± 5.32). Exercise was supervised and completed on a stationary exercise bicycle, and cognitive function was measured using a comprehensive neuropsychological battery administered pre‐ and post‐intervention. Sleep was measured using the Pittsburgh sleep quality index. There was no effect of the exercise intervention on any sleep outcomes from pre‐ to post‐intervention.ResultsThere was a significant moderating effect of baseline sleep efficiency on both episodic memory and global cognition within the moderate intensity exercise group, such that those with poorer sleep efficiency at baseline showed greater exercise‐induced improvements in episodic memory.ConclusionsThese results suggest that those with poorer sleep may have the greatest exercise‐induced cognitive benefits and that baseline sleep behaviours may be an important source of heterogeneity in previous exercise interventions targeting cognitive outcomes.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The influence of baseline sleep on exercise‐induced cognitive change in cognitively unimpaired older adults: A randomised clinical trial

Sewell,

Rainey‐Smith,

Peiffer

et al. 2023

Int J Geriat Psychiatry

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“…This study also found that physical activity is an important factor in uencing the occurrence of SMI among the elderly. In this study, elderly individuals who engage in medium-to high-level intensity physical activity tended to have better memories, which is supported by previous studies indicating that the amount of total physical activity is the main factor affecting the cognitive function of the elderly [55][56][57] .…”

Section: Discussionsupporting

confidence: 87%

Interaction Effect of Midday Napping Duration and Depressive Symptoms on Subjective Memory Impairment Among Elderly People in China: Evidence from the China Health and Retirement Longitudinal Study Database

Li¹,

Wang²,

Zhan³

et al. 2023

Preprint

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Background Subjective memory impairment (SMI) is common in the elderly. We aimed to reveal the interaction effect of midday napping duration and depressive symptoms on the risk of SMI. Methods Using a dataset representative of the Chinese population from a longitudinal study of health and retirement in China, subjects with SMI were screened using the question “how do you feel about your memory now?” and the Mini-Mental State Examination. A logistic regression model was applied to explore the factors affecting SMI. Additive and multiplicative models were used to analyze the interaction effect of midday napping duration and depressive symptoms on the risk of SMI. Results We enrolled 8,254 subjects included and the incidence of SMI was 63.9%. Depressive symptoms, nap time, and physical activity were influencing factors of SMI. Midday napping duration and depressive symptoms had positive additive interaction effects on the risk of SMI. When extended-length naps and depressive symptoms coexisted, the risk of SMI was 1.06 times greater than that for either alone (RERI = 0.27, 95% CI = 0.07–0.43; AP = 0.14, 95% CI = 0.01–0.23; S = 1.06, 95% CI = 0.57–1.62). When short naps and depressive symptoms coexisted, the risk of SMI was 1.2 times higher than that for either alone (RERI = 0.12, 95% CI=-0.14–0.39; AP = 0.13, 95% CI=-0.07–0.22; S = 1.20, 95% CI = 0.79–1.82). Limitations Since this was a cross-sectional study, the cause-and-effect relationships between the associated variables cannot be inferred. Conclusions The interaction effect that exists between nap time and depressive symptoms in the elderly is important for the identification and early intervention of people at risk for SMI.

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“…We did not detect a significant interaction between 24-h time-use composition and sleep quality in association with any of the cognitive measures. Although this interaction has never been directly tested previously, findings from some studies have suggested that perceived sleep quality is important to consider when exploring the relationship between physical activity, sleep duration and cognitive outcomes ( Nakakubo et al, 2017 ; Yuan et al, 2020 ; Sewell et al, 2023 ). The lack of evidence supporting this relationship in the current study may be due to several factors.…”

Section: Discussionmentioning

confidence: 99%

Twenty-four-hour time-use composition and cognitive function in older adults: cross-sectional findings of the ACTIVate study

Mellow

Dumuid²,

Wade³

et al. 2022

Front. Hum. Neurosci.

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IntroductionPhysical activity, sedentary behaviour and sleep are associated with cognitive function in older adults. However, these behaviours are not independent, but instead make up exclusive and exhaustive components of the 24-h day. Few studies have investigated associations between 24-h time-use composition and cognitive function in older adults. Of these, none have considered how the quality of sleep, or the context of physical activity and sedentary behaviour may impact these relationships. This study aims to understand how 24-h time-use composition is associated with cognitive function across a range of domains in healthy older adults, and whether the level of recreational physical activity, amount of television (TV) watching, or the quality of sleep impact these potential associations.Methods384 healthy older adults (age 65.5 ± 3.0 years, 68% female, 63% non-smokers, mean education = 16.5 ± 3.2 years) participated in this study across two Australian sites (Adelaide, n = 207; Newcastle, n = 177). Twenty-four-hour time-use composition was captured using triaxial accelerometry, measured continuously across 7 days. Total time spent watching TV per day was used to capture the context of sedentary behaviours, whilst total time spent in recreational physical activity was used to capture the context of physical activity (i.e., recreational accumulation of physical activity vs. other contexts). Sleep quality was measured using a single item extracted from the Pittsburgh Sleep Quality Index. Cognitive function was measured using a global cognition index (Addenbrooke’s Cognitive Examination III) and four cognitive domain composite scores (derived from five tests of the Cambridge Neuropsychological Test Automated Battery: Paired Associates Learning; One Touch Stockings of Cambridge; Multitasking; Reaction Time; Verbal Recognition Memory). Pairwise correlations were used to describe independent relationships between time use variables and cognitive outcomes. Then, compositional data analysis regression methods were used to quantify associations between cognition and 24-h time-use composition.ResultsAfter adjusting for covariates and false discovery rate there were no significant associations between time-use composition and global cognition, long-term memory, short-term memory, executive function, or processing speed outcomes, and no significant interactions between TV watching time, recreational physical activity engagement or sleep quality and time-use composition for any cognitive outcomes.DiscussionThe findings highlight the importance of considering all activities across the 24-h day against cognitive function in older adults. Future studies should consider investigating these relationships longitudinally to uncover temporal effects.

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The interaction between physical activity and sleep on cognitive function and brain beta-amyloid in older adults

Cited by 11 publications

References 41 publications

The influence of baseline sleep on exercise‐induced cognitive change in cognitively unimpaired older adults: A randomised clinical trial

The influence of baseline sleep on exercise‐induced cognitive change in cognitively unimpaired older adults: A randomised clinical trial

Interaction Effect of Midday Napping Duration and Depressive Symptoms on Subjective Memory Impairment Among Elderly People in China: Evidence from the China Health and Retirement Longitudinal Study Database

Twenty-four-hour time-use composition and cognitive function in older adults: cross-sectional findings of the ACTIVate study

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