The Interaction between Orally Administered Non-Steroidal Anti-Inflammatory Drugs and Prednisolone in Healthy Dogs

Narita, Tatsuya; Sato, Ryo; Motoishi, Keita; Tani, Kenji; Naito, Yoshihisa; Hara, Shigeo

doi:10.1292/jvms.69.353

Cited by 35 publications

(19 citation statements)

References 40 publications

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“…; Narita et al . ). Evidence supporting NSAID administration as a cause of equine glandular gastric ulceration syndrome (EGGUS) at a population level is weak (Sykes and Jokisalo ).…”

Section: Discussionmentioning

confidence: 97%

The use of multimodal analgesia in the management of suspected extremity compartment syndrome in the pelvic limb of a horse

Bruniges

Milner

Bardell

2017

Equine Veterinary Education

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Summary A 12‐year‐old Thoroughbred cross Dartmoor mare was referred to the clinic with marked lameness and swelling involving the left stifle region. There was poor initial response to medical management and arthroscopic examination of the stifle joint was performed under general anaesthesia. Following surgery, the lameness and swelling worsened and extremity compartment syndrome was suspected. A multimodal analgesia protocol was instigated to provide adequate analgesia and improved mobility, aiding the use of physical therapy in resolving the swelling. This report demonstrates the successful combination of nonsteroidal anti‐inflammatories, paracetamol, ketamine infusion and epidural opioid administration to manage the clinical signs. The mare was discharged from hospital after 15 days and at short‐term follow‐up (3 months), there was no reported residual swelling or lameness.

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“…; Narita et al . ). Evidence supporting NSAID administration as a cause of equine glandular gastric ulceration syndrome (EGGUS) at a population level is weak (Sykes and Jokisalo ).…”

Section: Discussionmentioning

confidence: 97%

The use of multimodal analgesia in the management of suspected extremity compartment syndrome in the pelvic limb of a horse

Bruniges

Milner

Bardell

2017

Equine Veterinary Education

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“…Administration of NSAIDs with corticosteroids can significantly increase the risk of gastrointestinal toxicity. The combination of prednisolone with either ketoprofen or meloxicam resulted in considerable adverse effects on the kidney, gastrointestinal mucosa and platelet function in dogs (Narita et al. 2007).…”

Section: Adverse Class‐effects Of Nsaidsmentioning

confidence: 99%

Clinical pharmacology of nonsteroidal anti-inflammatory drugs in dogs

KuKanich

Bidgood

Knesl

2012

Veterinary Anaesthesia and Analgesia

135

132

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“…Urinary NAG (uNAG) has proven to be a useful tool in early detection of renal injury in various human diseases as reviewed by Skalova 11 . In veterinary medicine, an increased uNAG‐to‐creatinine ratio (uNAG/c) has been observed in dogs in various stages of CKD, 12,13 leishmaniasis, 14 and pyometra 13,15 and in dogs treated with nephrotoxic antibiotics, 16 NSAIDS, or glucocorticoids 17 …”

mentioning

confidence: 99%

“…11 In veterinary medicine, an increased uNAG-to-creatinine ratio (uNAG/c) has been observed in dogs in various stages of CKD, 12,13 leishmaniasis, 14 and pyometra 13,15 and in dogs treated with nephrotoxic antibiotics, 16 NSAIDS, or glucocorticoids. 17 Most studies in dogs have focused on 1 urinary marker, whereas reports on the combined measurement of glomerular and tubular markers in healthy and CKD dogs are scarce. Data about urinary marker assay validation likewise are scarce, especially for NAG.…”

mentioning

confidence: 99%

Urinary Markers in Healthy Young and Aged Dogs and Dogs with Chronic Kidney Disease

Smets

Meyer

Maddens

et al. 2010

Veterinary Internal Medicne

101

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Background: Blood urea nitrogen and serum creatinine concentrations only detect a decrease of 475% of renal functional mass. Therefore, there is a need for markers that allow early detection and localization of renal damage.Hypothesis: Urinary albumin (uALB), C-reactive protein (uCRP), retinol binding protein (uRBP), and N-acetyl-b-Dglucosaminidase (uNAG) concentrations are increased in dogs with chronic kidney disease (CKD) compared with healthy controls and in healthy older dogs compared with young dogs.Animals: Ten dogs with CKD, 10 healthy young dogs (age 1-3 years), and 10 healthy older dogs (age 4 7 years) without clinically relevant abnormalities on physical examination, hematology, biochemistry, and urinalysis.Methods: Urinary markers were determined using an ELISA (uALB, uCRP, and uRBP) or a colorimetric test (uNAG). Results were related to urinary creatinine (c). The fixed effects model or the Wilcoxon rank sum test were used to compare the different groups of dogs.Results: uALB/c, uRBP/c, and uNAG/c were significantly higher in CKD dogs than in healthy dogs. No significant difference was found for uCRP, which was not detectable in the healthy dogs and only in 3 of the CKD dogs. Between the healthy young and older dogs, no significant difference was detected for any of the markers.Conclusion: The urinary markers uALB/c, uRBP/c, and uNAG/c were significantly increased in dogs with CKD compared with healthy controls. Additional studies are needed to evaluate the ability of these markers to detect renal disease before the onset of azotemia.

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The Interaction between Orally Administered Non-Steroidal Anti-Inflammatory Drugs and Prednisolone in Healthy Dogs

Cited by 35 publications

References 40 publications

The use of multimodal analgesia in the management of suspected extremity compartment syndrome in the pelvic limb of a horse

The use of multimodal analgesia in the management of suspected extremity compartment syndrome in the pelvic limb of a horse

Clinical pharmacology of nonsteroidal anti-inflammatory drugs in dogs

Urinary Markers in Healthy Young and Aged Dogs and Dogs with Chronic Kidney Disease

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