The interaction between obesity and visceral hypersensitivity

Abstract

Obesity has been a worldwide problem associated with numerous chronic diseases such as cardiovascular disease, type 2 diabetes, and metabolic disorders. It may also play a role in visceral hypersensitivity, contributing to irritable bowel syndrome. (i) Adipose tissue secretes various inflammatory mediators, causing intestinal hyperpermeability and nerve endings activation. (ii) Obesity and gastrointestinal microbiota could affect each other, and microbial metabolites can increase sensitivity of the colon. (iii) Vitamin D deficiency contributes to both fat accumulation and disruption of the intestinal mucosal barrier. (iv) Brain‐gut axis may be another bridge from obesity to visceral hypersensitivity.

Obesity and functional gastrointestinal disorders: What is the link?

“…In this issue of the journal, Yanping et al postulate that obesity may lead to FGIDS, particularly IBS, by increasing visceral hypersensitivity. 8 Visceral hypersensitivity is one of the pathophysiological mechanisms involved in generating symptoms in IBS, mainly by having a lower pain threshold to bowel distension or an increased sensitivity to normal intestinal function. 2 The authors suggest that obesity may be involved in hyperexcitability of primary visceral afferent fibers at the intestinal level and enhanced perception of the intestinal signal in the brain.…”

“…In this issue of the journal, Yanping et al . postulate that obesity may lead to FGIDS, particularly IBS, by increasing visceral hypersensitivity 8 . Visceral hypersensitivity is one of the pathophysiological mechanisms involved in generating symptoms in IBS, mainly by having a lower pain threshold to bowel distension or an increased sensitivity to normal intestinal function 2 .…”

The Role of Intestinal Barrier Function in Overweight Patients with IBS with Diarrhea Undergoing a Long-Term Low Fermentable Oligo-, Di-, and Monosaccharide and Polyol Diet

“…The pathophysiology of IBS is partly understood, with associated factors including lifestyle, mental illness, and chronic inflammation [1]. Overweight and obesity have also been suggested as significant factors in IBS development [2]. Epidemiological data show a higher prevalence of IBS symptoms, such as abdominal discomfort or pain and altered bowel habits, among obese individuals compared with those with normal weight [3].…”