The Interaction Between Nutrition and Inflammatory Stress Throughout the Life Cycle

Grimble, Robert F.

doi:10.1385/1-59259-952-4:387

Cited by 1 publication

(1 citation statement)

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“…During catabolic stress, namely sepsis, its levels rapidly decrease [ 67 ]. Glutamine is also important since it maintains gut barrier function [ 68 ], which prevents the progression of inflammation and infection in AP. In this study, plasma glutamine concentration was decreased in the patients with biliary AP, suggesting that it inhibits the metabolization of this substrate by repressing the metabolization of glutamine at some level.…”

Section: Discussionmentioning

confidence: 99%

Plasmatic Oxidative and Metabonomic Profile of Patients with Different Degrees of Biliary Acute Pancreatitis Severity

et al. 2021

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(1) Background: Acute pancreatitis (AP) is an inflammatory process of the pancreas with variable involvement of the pancreatic and peripancreatic tissues and remote organ systems. The main goal of this study was to evaluate the inflammatory biomarkers, oxidative stress (OS), and plasma metabolome of patients with different degrees of biliary AP severity to improve its prognosis. (2) Methods: Twenty-nine patients with biliary AP and 11 healthy controls were enrolled in this study. We analyzed several inflammatory biomarkers, multifactorial scores, reactive oxygen species (ROS), antioxidants defenses, and the plasma metabolome of biliary AP and healthy controls. (3) Results: Hepcidin (1.00), CRP (0.94), and SIRI (0.87) were the most accurate serological biomarkers of AP severity. OS played a pivotal role in the initial phase of AP, with significant changes in ROS and antioxidant defenses relating to AP severity. Phenylalanine (p < 0.05), threonine (p < 0.05), and lipids (p < 0.01) showed significant changes in AP severity. (4) Conclusions: The role of hepcidin and SIRI were confirmed as new prognostic biomarkers of biliary AP. OS appears to have a role in the onset and progression of the AP process. Overall, this study identified several metabolites that may predict the onset and progression of biliary AP severity, constituting the first metabonomic study in the field of biliary AP.

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Section: Discussionmentioning

confidence: 99%