The interaction between nanoscale surface features and mechanical loading and its effect on osteoblast-like cells behavior

Prodanov, Ljupcho; Riet, Joost te; Lamers, Edwin; Domański, Maciej; Lüttge, Regina; Loon, Jack J. W. A. van; Jansen, John A.; Walboomers, X. Frank

doi:10.1016/j.biomaterials.2010.06.050

Cited by 72 publications

(67 citation statements)

References 38 publications

(21 reference statements)

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“…Nevertheless, we can observe that the results obtained for very small and large patterns are qualitatively in agreement with the experiments of Prodanov et al (28), who observed that osteoblast-like cells exhibit SA behavior when cultured on relatively small grooves, and CG behavior in case of large grooves. On the other hand, when quantitatively compared, the model predictions do not match perfectly with the experimental observations.…”

Section: Discussionsupporting

confidence: 92%

“…The parameters used for the computational simulations were very similar to the ones chosen in Vigliotti et al (42) and Wei et al (39), and are reported in Table 1. The computational simulations were repeated for several pitch sizes ð0:05 mm%L 0 %1 mmÞ and strain amplitudes ð0:01%ε 22;max %0:08Þ, consistent with Vigliotti et al (42) and Prodanov et al (28). Similar to this last study, the cyclic strain frequency was chosen equal to 1 Hz, to mimic physiological conditions.…”

Section: Sf Dynamicsmentioning

confidence: 98%

“…To investigate the validity of our hypothesis, the numerical model of Vigliotti et al (42) was extended to analyze the behavior of SFs and FAs of cells cultured on cyclically stretched grooved surfaces (or linear topographical patterns), as cells in this context are subjected to stimuli that induce both SA (stretch) and CG (grooves/patterns). The experiments of Prodanov et al (28) were chosen as a reference to qualitatively assess our numerical predictions, due to the similarities with the study of Lamers et al (9) previously simulated by Vigliotti et al (42). In addition, cellular behaviors resulting from experimental conditions different from the ones reported in the literature were predicted, which could be helpful for the development of new experimental designs.…”

Section: Introductionmentioning

confidence: 95%

“…The experiments of Prodanov et al (28) are particularly interesting. In their study, the authors used the same technique for the fabrication of grooves and a similar cell type as reported in Lamers et al (9) and, in addition, they mechanically stimulated cells along the direction of the patterns.…”

Section: Introductionmentioning

confidence: 96%

“…Many different experimental studies have been performed to investigate the final outcome of this competition (22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33). The final cellular organization in these studies appeared to depend on several factors, such as the amplitude of the applied cyclic strain, the size of the used topographical features, and the type of cells investigated.…”

Section: Introductionmentioning

confidence: 99%

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Prediction of Cell Alignment on Cyclically Strained Grooved Substrates

Ristori

Vigliotti

Baaijens

et al. 2016

Biophysical Journal

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Cells respond to both mechanical and topographical stimuli by reorienting and reorganizing their cytoskeleton. Under certain conditions, such as for cells on cyclically stretched grooved substrates, the effects of these stimuli can be antagonistic. The biophysical processes that lead to the cellular reorientation resulting from such a competition are not clear yet. In this study, we hypothesized that mechanical cues and the diffusion of the intracellular signal produced by focal adhesions are determinants of the final cellular alignment. This hypothesis was investigated by means of a computational model, with the aim to simulate the (re)orientation of cells cultured on cyclically stretched grooved substrates. The computational results qualitatively agree with previous experimental studies, thereby supporting our hypothesis. Furthermore, cellular behavior resulting from experimental conditions different from the ones reported in the literature was simulated, which can contribute to the development of new experimental designs.

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Section: Discussionsupporting

confidence: 92%

Section: Sf Dynamicsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Prediction of Cell Alignment on Cyclically Strained Grooved Substrates

Ristori

Vigliotti

Baaijens

et al. 2016

Biophysical Journal

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Ultrashort Pulsed Laser Surface Patterning of Titanium to Improve Osseointegration of Dental Implants

et al. 2019

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Ultrashort pulsed direct laser interference patterning (DLIP) is used to generate hierarchical line‐like patterns on titanium surfaces to control cell adhesion and spreading on dental implants, thereby improving osseointegration. The DLIP structures have spatial periods of 3, 5, 10, and 17 μm. They are produced using a laser source with a pulse duration of 10 ps and cumulated energy densities between 0.1 and 78.9 J cm−2. Laser‐induced periodic surface structures (LIPSS) and submicron features are obtained on the treated samples. The DLIP treatment leads to the development of a thick titanium oxide layer, which is imaged and quantified using time‐of‐flight secondary ion mass spectrometry (ToF‐SIMS). Several days (30–56) after the laser treatment, specimens with larger spatial periods are hydrophilic, whereas samples with spatial periods of 3 μm are hydrophobic. Seeded human osteoblasts on the laser‐structured samples show 2.5 times higher cell numbers after 7 days in vitro culture compared with osteoblasts on a grit‐blasted and etched reference sample. Finally, cell adhesion to a structured 3D dental implant is demonstrated.

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Laser Surface Pattering of Titanium for Improving the Biological Performance of Dental Implants

Zwahr

Günther

Brinkmann

et al. 2016

Adv Healthcare Materials

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Direct laser interference patterning (DLIP) is used to produce periodic line-like patterns on titanium surfaces. An Nd:YAG laser operating at 532 nm wavelength with a pulse duration of 8 ns is used for the laser patterning process. The generated periodic patterns with spatial periods of 5, 10, and 20 µm are produced with energy densities between 0.44 and 2.6 J cm with a single laser pulse. With variation of energy density, different shapes of the arising topography are observed due to the development of the solidification front of the molten material at the maxima positions. Characterization of the surface chemistry shows that the DLIP treatment enhances the content of nitrogen of the titanium reactive layer from 3.9% up to 23.4%. The structural analysis near the titanium surface shows no changes in microstructure after the laser treatment. Contact angles between 65° and 79° are measured on both structured and turned reference surfaces. Cell viability of human osteoblasts on line-like patterned surfaces after 7 d in cultivation medium is 16% higher compared to the grit-blasted and acid-etched references. Finally, the possibility of patterning complex 3D dental implants is shown.

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The interaction between nanoscale surface features and mechanical loading and its effect on osteoblast-like cells behavior

Cited by 72 publications

References 38 publications

Prediction of Cell Alignment on Cyclically Strained Grooved Substrates

Prediction of Cell Alignment on Cyclically Strained Grooved Substrates

Ultrashort Pulsed Laser Surface Patterning of Titanium to Improve Osseointegration of Dental Implants

Laser Surface Pattering of Titanium for Improving the Biological Performance of Dental Implants

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