The interaction between miRNAs/lncRNAs and Notch pathway in human disorders

Ghafouri‐Fard, Soudeh; Glassy, Mark C.; Abak, Atefe; Hussen, Bashdar Mahmud; Niazi, Vahid; Taheri, Mohammad

doi:10.1016/j.biopha.2021.111496

Cited by 37 publications

(26 citation statements)

References 66 publications

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“…SRY‐box transcription factor 9 ( SOX9 ), as a member of SOX family, can keeps cells in undifferentiated state during development and is correlated with many signalling pathways such as NOTCH , transforming growth factor‐beta (TGF‐β)/Smad and Wnt/β‐catenin. 97 , 98 SOX9 has been reported to be implicated in regulating various cellular processes including proliferation, apoptosis, migration, invasion, chemoresistance, autophagy, angiogenesis, immune escape and metastasis by controlling the transcription of a multitude of genes. 99 , 100 Multiple lines of evidence support the suggestion that SOX9 is involved in the development of diverse types of malignancies such as bladder, brain, colon, cervical, gastric, endometrial, liver, and head and neck cancers.…”

Section: Competing Endogenous Rna Network (Cerna)mentioning

confidence: 99%

Non‐coding RNA‐associated competitive endogenous RNA regulatory networks: Novel diagnostic and therapeutic opportunities for hepatocellular carcinoma

Moghadam

Bakhshinejad

Khalafizadeh

et al. 2021

J Cellular Molecular Medi

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Hepatocellular carcinoma (HCC), as the most prevalent liver malignancy, is annually diagnosed in more than half a million people worldwide. HCC is strongly associated with hepatitis B and C viral infections as well as alcohol abuse. Obesity and nonalcoholic fatty liver disease (NAFLD) also significantly enhance the risk of liver cancer. Despite recent improvements in therapeutic approaches, patients diagnosed in advanced stages show poor prognosis. Accumulating evidence provides support for the regulatory role of non‐coding RNAs (ncRNAs) in cancer. There are a variety of reports indicating the regulatory role of microRNAs (miRNAs) in different stages of HCC. Long non‐coding RNAs (LncRNAs) exert their effects by sponging miRNAs and controlling the expression of miRNA‐targeted genes. Circular RNAs (circRNAs) perform their biological functions by acting as transcriptional regulators, miRNA sponges and protein templates. Diverse studies have illustrated that dysregulation of competing endogenous RNA networks (ceRNETs) is remarkably correlated with HCC‐causing diseases such as chronic viral infections, nonalcoholic steatohepatitis and liver fibrosis/cirrhosis. The aim of the current article was to provide an overview of the role and molecular mechanisms underlying the function of ceRNETs that modulate the characteristics of HCC such as uncontrolled cell proliferation, resistance to cell death, metabolic reprogramming, immune escape, angiogenesis and metastasis. The current knowledge highlights the potential of these regulatory RNA molecules as novel diagnostic biomarkers and therapeutic targets in HCC.

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Section: Competing Endogenous Rna Network (Cerna)mentioning

confidence: 99%

Non‐coding RNA‐associated competitive endogenous RNA regulatory networks: Novel diagnostic and therapeutic opportunities for hepatocellular carcinoma

Moghadam

Bakhshinejad

Khalafizadeh

et al. 2021

J Cellular Molecular Medi

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“… 88 Notch functions on chondrogenesis using both CSL (CBF1, suppressor of hairless, Lag‐1)‐dependent and CSL‐independent mechanisms. 89 , 90 Upon activation, Notch signalling controls a balance between the chondrogenic proliferation and differentiation at the early stages of somite compartmentalization and the long bone development. 89 Notch promotes the final differentiation of the osteoblast progenitors but seems to have no obvious effects on mature osteoblasts.…”

Section: Smad4 Functions Through Different Signalling Pathwaysmentioning

confidence: 99%

SMAD4 contributes to chondrocyte and osteocyte development

Pakravan

Razmara

Hussen

et al. 2021

J Cellular Molecular Medi

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The formation of skeletal elements often follows a basic path that involves different chondrogenic and osteogenic programmes. 1 Among these, a significant number of signalling pathways, eg SMAD family, play roles. The term 'SMAD' was coined from a combination of a gene name from Caenorhabditis elegans SMA ("small" worm phenotype) and MAD family ("mothers against decapentaplegic") of genes in Drosophila melanogaster. 2 By considering their functions, eight members of SMAD proteins are categorized into three main classes including (i) receptor-regulated or regulatory SMADs (also known as R-SMADs), ie SMADs 1, 2, 3, 5 and 8, (ii) common SMAD or co-SMAD that only involves SMAD4 and (iii) inhibitory SMADs (I-SMADs) that

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“…Notch-induced lncRNAs, such as LUNAR1 , associates with reduced apoptosis of CRC cells and overall patient survival [ 174 ], while Notch-inducing lncRNAs, like prostate cancer-upregulated long noncoding RNA 1 ( PlncRNA-1 ) function as an apoptosis inducer in glioma tumors [ 175 ]. Similarly, lncRNA antisense non-coding RNA in the INK4 locus ( ANRIL ) inhibits apoptosis and enhances progression of GC cells by targeting among others the Notch pathway [ 176 , 177 ].…”

Section: Cancer Stem Cells Lncrnas and Tumor Immune Escapementioning

confidence: 99%

Long Non-Coding RNAs (lncRNAs) in Response and Resistance to Cancer Immunosurveillance and Immunotherapy

Eptaminitaki

Wolff

Stellas

et al. 2021

Cells

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Long non-coding RNAs (lncRNAs) are critical regulatory elements in cellular functions in states of both normalcy and disease, including cancer. LncRNAs can influence not only tumorigenesis but also cancer features such as metastasis, angiogenesis and resistance to chemo-and immune-mediated apoptotic signals. Several lncRNAs have been demonstrated to control directly or indirectly the number, type and activities of distinct immune cell populations of adaptive and innate immunities within and without the tumor microenvironment. The disruption of lncRNA expression in both cancer and immune cells may reflect alterations in tumor responses to cancer immunosurveillance and immunotherapy, thus providing new insights into lncRNA biomarker-based prognostic and therapeutic cancer assessment. Here we present an overview on lncRNAs’ functions and underlying molecular mechanisms related to cancer immunity and conventional immunotherapy, with the expectation that any elucidations may lead to a better understanding and management of cancer immune escape and response to current and future immunotherapeutics.

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The interaction between miRNAs/lncRNAs and Notch pathway in human disorders

Cited by 37 publications

References 66 publications

Non‐coding RNA‐associated competitive endogenous RNA regulatory networks: Novel diagnostic and therapeutic opportunities for hepatocellular carcinoma

Non‐coding RNA‐associated competitive endogenous RNA regulatory networks: Novel diagnostic and therapeutic opportunities for hepatocellular carcinoma

SMAD4 contributes to chondrocyte and osteocyte development

Long Non-Coding RNAs (lncRNAs) in Response and Resistance to Cancer Immunosurveillance and Immunotherapy

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