The Interaction between Intratumoral Microbiome and Immunity Is Related to the Prognosis of Ovarian Cancer

Sheng, Dashuang; Yue, Kaile; Li, Hongfeng; Zhao, Lanlan; Zhao, Guoping; Jin, Chuandi; Zhang, Lei

doi:10.1128/spectrum.03549-22

Cited by 9 publications

(9 citation statements)

References 77 publications

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“…The ovarian cancer could be divided into immune‐enriched and immune‐deficient subtypes, which are correlated with the intratumor microbiome. And intratumor microbiome is closely associated with the prognosis of patients 105 . The immune histopathological parameters such as PD‐L1 expression and tumor‐infiltrating lymphocytes were significantly associated with alpha and beta diversity of intratumor microbiome 37 .…”

Section: Mechanisms Of Intratumor Microbiome In Modulating Tumor Init...mentioning

confidence: 96%

Intratumor microbiome: selective colonization in the tumor microenvironment and a vital regulator of tumor biology

Jiang,

Yang,

Dai

et al. 2023

MedComm

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The polymorphic microbiome has been proposed as a new hallmark of cancer. Intratumor microbiome has been revealed to play vital roles in regulating tumor initiation and progression, but the regulatory mechanisms have not been fully uncovered. In this review, we illustrated that similar to other components in the tumor microenvironment, the reside and composition of intratumor microbiome are regulated by tumor cells and the surrounding microenvironment. The intratumor hypoxic, immune suppressive, and highly permeable microenvironment may select certain microbiomes, and tumor cells may directly interact with microbiome via molecular binding or secretions. Conversely, the intratumor microbiomes plays vital roles in regulating tumor initiation and progression via regulating the mutational landscape, the function of genes in tumor cells and modulating the tumor microenvironment, including immunity, inflammation, angiogenesis, stem cell niche, etc. Moreover, intratumor microbiome is regulated by anti‐cancer therapies and actively influences therapy response, which could be a therapeutic target or engineered to be a therapy weapon in the clinic. This review highlights the intratumor microbiome as a vital component in the tumor microenvironment, uncovers potential mutual regulatory mechanisms between the tumor microenvironment and intratumor microbiome, and points out the ongoing research directions and drawbacks of the research area, which should broaden our view of microbiome and enlighten further investigation directions.

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Section: Mechanisms Of Intratumor Microbiome In Modulating Tumor Init...mentioning

confidence: 96%

Intratumor microbiome: selective colonization in the tumor microenvironment and a vital regulator of tumor biology

Jiang,

Yang,

Dai

et al. 2023

MedComm

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show abstract

“…Acinetobacter seifertii participates in the formation of an immunodeficient TME by inhibiting M1 macrophage migration and affecting macrophage involvement in antigen processing and presentation by attenuating T cell function. 22 Similarly, actinomycetes in colorectal cancer regulate TLR2, TLR4, and nuclear factor kappa-B (NF-κB), affecting the infiltration of immune cells in the TME. In particular, the activation of the TLR2/NF-κB pathway reduces the infiltration of CD8+ T lymphocytes in the colorectal cancer microenvironment, suppressing the tumor immune response.…”

Section: Itm Reshapes the Tme For Tumor Developmentmentioning

confidence: 99%

“…60 As an essential component of the TME, tumor microbial DNA is actively involved in this continually evolving landscape. 2,22,23,37 Consequently, changes in tumor microbial DNA inevitably reflect alterations in the tumor itself. The method of detecting tumor microbial DNA in the blood requires extensive exploration through numerous experiments, given its limited presence in tumor tissues and dilution within the bloodstream.…”

Section: Exploration and Controversies In The Early Diagnosis Of Itm ...mentioning

confidence: 99%

“…ITM participate in the formation of an immunodeficient environment by affecting immune cells, thus favoring the development and metastasis of cancer cells. Acinetobacter seifertii participates in the formation of an immunodeficient TME by inhibiting M1 macrophage migration and affecting macrophage involvement in antigen processing and presentation by attenuating T cell function 22 . Similarly, actinomycetes in colorectal cancer regulate TLR2, TLR4, and nuclear factor kappa‐B (NF‐κB), affecting the infiltration of immune cells in the TME.…”

Section: Interplay Between Itm and The Tme In Tumor Developmentmentioning

confidence: 99%

“…A combination of five microorganisms ( Achromobacter deleyi , Microcella alkaliphila , Devosia spp. strain LEGU1, Ancylobacter pratisalsi , and A. seifertii ) differentiate between immune‐enriched and immune‐deficient phenotypes of breast cancer 22 . These five ITM are highly correlated with the density of M1‐type macrophages within the tumor, potentially influencing the upregulation of genes involved in antigen processing and expression and enhancing T cell responses; therefore, patients with a positive combination of marker groups exhibit a more favorable prognosis for immune enrichment 22 .…”

Section: Itm Identification For Tumor Diagnosis and Stagingmentioning

confidence: 99%

See 2 more Smart Citations

The value of intratumoral microbiota in the diagnosis and prognosis of tumors

Zhou,

Zhang,

Fan

et al. 2024

Cell Biochemistry & Function

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Intratumoral microbiota (ITM) are microorganisms present in tumor cells. ITM participate in tumor development by affecting tumor cells directly and the tumor microenvironment (TME), indirectly. Alterations in ITM instigate changes in tumor DNA, activate oncogenic pathways, induce tumor inflammatory responses, disrupt normal immune activity, and facilitate the secretion of effectors leading to tumor progression, metastasis, or diminished therapeutic effects. ITM varies significantly in different types of cancer cells and disease states. The presence of certain ITM serves as a predictor of various disease states. Thus, ITM predicts tumorigenesis, tumor grade, treatment efficacy, and prognosis, making it a potential tumor biomarker. The present study aimed to determine the mechanisms by which ITM affects tumor development, especially through the TME; highlight the significant potential of ITM in enhancing tumor diagnosis and prognosis; and outline future directions for ITM research, with a focus on the development of innovative tumor markers.

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Broadening oncological boundaries: the intratumoral microbiota

Lu,

Qiao,

Tan

et al. 2024

Trends in Microbiology

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The Interaction between Intratumoral Microbiome and Immunity Is Related to the Prognosis of Ovarian Cancer

Abstract: Recent studies have demonstrated the existence of intratumoral microorganisms. However, the role of intratumoral microbes in the development of ovarian cancer and their interaction with the tumor microenvironment are largely unknown.

Cited by 9 publications

References 77 publications

Intratumor microbiome: selective colonization in the tumor microenvironment and a vital regulator of tumor biology

Intratumor microbiome: selective colonization in the tumor microenvironment and a vital regulator of tumor biology

The value of intratumoral microbiota in the diagnosis and prognosis of tumors

Broadening oncological boundaries: the intratumoral microbiota

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