The Interaction between Gut Microbiota and Host Amino Acids Metabolism in Multiple Myeloma

Abstract

Although novel therapies have dramatically improved outcomes for multiple myeloma (MM) patients, relapse is inevitable and overall outcomes are heterogeneous. The gut microbiota is becoming increasingly recognized for its influence on host metabolism. To date, evidence has suggested that the gut microbiota contributes to MM, not only via the progressive activities of specific bacteria but also through the influence of the microbiota on host metabolism. Importantly, the abnormal amino acid metabolism, as well as the altered microbiome in MM, is becoming increasingly apparent, as is the influence on MM progression and the therapeutic response. Moreover, the gut-microbiota–host-amino-acid metabolism interaction in the progression of MM has been highlighted. Modulation of the gut microbiota (such as fecal microbiota transplantation, FMT) can be modified, representing a new angle in MM treatment that can improve outcomes. In this review, the relationship between gut microbiota, metabolism, and MM, together with strategies to modulate the microbiota, will be discussed, and some unanswered questions for ongoing and future research will be presented.

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“…In addition, the interaction between amino acid metabolism and intestinal flora also plays a certain role in constipation. g__Clostridia_vadinBB60_group, g__Odoribacter, and g__Lachnospirace_NK4A136_group are closely related to amino acid metabolism [42]. Based on the correlation results mentioned above, three targets were identified: SOD1, AQP1, and MUC2.…”

Ferroptosis: a potential bridge linking gut microbiota and chronic kidney disease

“…For instance, supplementation with BCAAs can alleviate gut microbial dysbiosis, improving amino acid metabolism and host growth performance [ 79 ]. The impact of the gut microbiota on host amino acid metabolism can further influence disease progression and therapeutic response [ 80 ]. Understanding the complicated relationship between the gut microbiota and amino acid metabolism is critical for elucidating disease progression and optimizing therapeutic interventions.…”

Extraction Methods Determine the Quality of Soil Microbiota Acquisition

“…One of the most useful microbiome transplants is fecal microbiota transplantation (FMT) [ 5 ]. FMT has been used to treat a variety of human diseases, such as infectious diseases [ 6 , 7 ], inflammatory bowel diseases [ 8 , 9 , 10 , 11 , 12 ], oncological diseases [ 13 ], hematological diseases [ 14 , 15 ], and neurodegenerative diseases [ 16 ]. Additionally, microbes make an enormous contribution to environmental governance and can also assist in the elimination of pollutants from hyperthermal, acidic, hypersaline, or basic industrial waste [ 17 , 18 ].…”