The Interaction Between Dietary Fructose and Gut Microbiota in Hyperuricemia and Gout

Fang, Xinyu; Qi, Liang-wei; Chen, Haifeng; Gao, Peng; Zhang, Qin; Leng, Rui‐Xue; Fan, Yin‐Guang; Li, Baozhu; Pan, Hai‐Feng; Ye, Dong-Qing

doi:10.3389/fnut.2022.890730

Cited by 18 publications

(14 citation statements)

References 177 publications

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“…In recent years, HUA has become a common metabolic disease worldwide [ 1 ], characterized by elevated levels of uric acid (UA) in the blood, which affects patients of all ages and genders [ 2 ]. Studies have shown that the global incidence of HUA has been on the rise since the 1960s, and up to 2016, the global incidence of HUA has been as high as 21% [ 1 ]. The incidence rate in the United States ranges from 14.6% to 20% [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Association of Visceral Fat Area and Hyperuricemia in Non-Obese US Adults: A Cross-Sectional Study

Gao

Zhong

et al. 2022

Nutrients

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This study aimed to investigate the relationship between visceral fat area (VFA) and hyperuricemia (HUA) among non-obese adults. We extracted data from 6224 US adults aged 20–59 years from the National Health and Nutrition Examination Survey (NHANES) from 2011–2018. The VFA was divided into four quartiles (Q1–Q4). We used multivariable logistic regression models to control for known confounders. A generalized additive model (GAM) and restricted cubic spines were used to examine the association between VFA and HUA stratified by sex, and a two-piecewise linear regression model was used to calculate the threshold effect among males. The results revealed that the prevalence of HUA was 11.8% (men 15.8%, women 7.2%). In the fully adjusted model, there was a positive association between VFA and HUA [as a quartile variable, Q4 vs. Q1, odds ratio (OR): 3.77 and 95% confidence interval (CI): (2.47~5.75), p < 0.001, p for trend < 0.001; as a continuous variable, per 10 cm2 increment, OR (95%CI):1.10(1.07,1.14), p < 0.001]. Besides, this positive association remained significantly stratified by sex. Interestingly, we observed a nonlinear dose-response relationship between VFA and HUA in males (inflection point: 107.46 cm2). In conclusion, our study confirmed a significant positive relationship between VFA and HUA among non-obese adults and remained statistically significant when stratified by sex.

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Section: Introductionmentioning

confidence: 99%

Association of Visceral Fat Area and Hyperuricemia in Non-Obese US Adults: A Cross-Sectional Study

Gao

Zhong

et al. 2022

Nutrients

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“…Moreover, research suggests that a diet rich in fructose also affects the immune system and may disturb the body’s immune homeostasis through, for example, changes in the intestinal bacterial flora and the impact on the permeability of the intestinal barrier. Attention is paid not only to the role of fructose itself, but also to the impact of its metabolites on the immune system [ 64 ] Fang et al [ 65 ] drew attention to the effect of fructose on the intestinal microflora and the possibility of fructose-inducing inflammation, which both contribute to the formation of hyperuricemia and disorders in intestinal homeostasis.…”

Section: Fructose As a Potential Factor Influencing Hyperuricemia And...mentioning

confidence: 99%

High-Fructose Diet–Induced Hyperuricemia Accompanying Metabolic Syndrome–Mechanisms and Dietary Therapy Proposals

Lubawy

Formanowicz

2023

IJERPH

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Fructose is often used as a food ingredient due to its low production costs and sweetening power. In recent years, it has been noticed that people on a Western diet high in fructose have high levels of uric acid in their blood. It was recognized that the specific metabolism of fructose in the body might cause increased production of uric acid, which then may affect the intensification of lipogenesis and the development of metabolic syndrome (MetS), insulin resistance, gout, cardiovascular diseases, leptin resistance, or non-alcoholic fatty liver disease. So far, to treat hyperuricemia, it has been recommended to use a low-purine diet characterized by limiting protein-containing products. However, this recommendation often leads to an increased intake of carbohydrate-rich foods that may contain fructose. Increased fructose consumption may enhance the secretion of uric acid again and, consequently, does not have therapeutic effects. Therefore, instead of a low-purine diet, using healthy diets, such as DASH or the Mediterranean diet, which can benefit metabolic parameters, could be a better proposal. This article provides an overview of this approach, focusing on MetS and hyperuricemia among high-fructose dieters.

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“…In addition, studies have shown that an excessive fructose diet can affect gut microbiota composition through a series of damage to the intestinal barrier function of the inflammatory response. Therefore, a new method for gout treatment could be to limit the specific fructose intake and improve the composition of gut microbiota or targeted metabolite ( Fang et al., 2022 ).…”

Section: Treatment Of Goutmentioning

confidence: 99%

The role of gut microbiota in gout: Is gut microbiota a potential target for gout treatment

Tong

Zhang

Cheng

et al. 2022

Front. Cell. Infect. Microbiol.

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Numerous studies have demonstrated that gut microbiota is essential for the host’s health because it regulates the host’s metabolism, endocrine, and immune systems. In recent years, increasing evidence has shown that gut microbiota plays a role in the onset and progression of gout. Changes in the composition and metabolism of the gut microbiota, result in abnormalities of uric acid degradation, increasing uric acid generation, releasing pro-inflammatory mediators, and intestinal barrier damage in developing gout. As a result, gout therapy that targets gut microbiota has drawn significant interest. This review summarized how the gut microbiota contributes to the pathophysiology of gout and how gout affects the gut microbiota. Additionally, this study explained how gut microbiota might serve as a unique index for the diagnosis of gout and how conventional gout treatment medicines interact with it. Finally, prospective therapeutic approaches focusing on gut microbiota for the prevention and treatment of gout were highlighted, which may represent a future avenue in gout treatment.

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The Interaction Between Dietary Fructose and Gut Microbiota in Hyperuricemia and Gout

Cited by 18 publications

References 177 publications

Association of Visceral Fat Area and Hyperuricemia in Non-Obese US Adults: A Cross-Sectional Study

Association of Visceral Fat Area and Hyperuricemia in Non-Obese US Adults: A Cross-Sectional Study

High-Fructose Diet–Induced Hyperuricemia Accompanying Metabolic Syndrome–Mechanisms and Dietary Therapy Proposals

The role of gut microbiota in gout: Is gut microbiota a potential target for gout treatment

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