The interaction between baculoviruses and their insect hosts

Kong, Ming; Zuo, Huancong; Zhu, Feifei; Hu, Zhaoyang; Chen, Liang; Yang, Yanhua; Lv, Peng; Yao, Qin; Chen, Keping

doi:10.1016/j.dci.2018.01.019

Cited by 27 publications

(21 citation statements)

References 141 publications

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“…Baculoviruses interact with their host in many ways and have developed multiple strategies to increase their fitness and dispersion through the alteration of the physiology an behavior of the host (Cheng and Lynn, 2009;Kong et al, 2018). The neuropeptidergic system in insects is composed of signalling molecules playing a role in the chemical communication between cells (Elphick et al, 2018;Schoofs et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Neuropeptidome regulation after baculovirus infection. A focus on proctolin and its relevance in locomotion and digestion

Llopis-Giménez

Han

et al. 2020

Preprint

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Baculoviruses constitute a large group of invertebrate DNA viruses, predominantly infecting larvae of the insect order Lepidoptera. During a baculovirus infection, the virus spreads throughout the insect body producing a systemic infection in multiple larval tissues. Some behavioral and physiological changes in lepidopteran larvae have been described following a baculovirus infection and those changes could be connected with alterations in the host’s central nervous system (CNS). As a main component of the CNS, neuropeptides are small protein-like molecules functioning as neurohormones, neurotransmitters or neuromodulators. These peptides are involved in regulating animal physiology and behaviour and could also be targeted by baculoviruses in order to achieve host behavioural manipulations leading to increased viral fitness. In this study, we have investigated the effect of a Spodoptera exigua multiple nucleopolyhedrovirus (SeMNPV) infection on the neuropeptidome gene expression of Spodoptera exigua larval heads and brains. Expression of the gene encoding the neuropeptide proctolin was severely downregulated following infection and was chosen for further analysis. A recombinant Autographa californica multiple nucleopolyhedrovirus (AcMNPV) overexpressing the S. exigua proctolin gene was generated and used in bioassays using S. exigua larvae to study its influence on the viral infection. AcMNPV-proctolin infected larvae showed less locomotion activity and suffered a loss of weight compared to larvae infected with wild type AcMNPV or mock-infected larvae. These results provide additional information on the role of proctolin during a baculovirus infection, and offers a novel hypothesis for the molecular bases for the behavioral changes associated with a baculovirus infection.

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Section: Discussionmentioning

confidence: 99%

Neuropeptidome regulation after baculovirus infection. A focus on proctolin and its relevance in locomotion and digestion

Llopis-Giménez

Han

et al. 2020

Preprint

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“…Such an alternative uses members of the family Baculoviridae, enveloped double-stranded DNA viruses, collectively named baculoviruses. Baculoviruses infect more than 600 insect species but are harmless to mammals (Lin et al 2014;Kong et al 2018). Of the many members of the Baculoviridae family, AcMNPV is the workhorse for producing recombinant proteins using insect cell lines (Felberbaum 2015;Van Oers et al 2015).…”

Section: Baculovirus Vectorsmentioning

confidence: 99%

Current view on novel vaccine technologies to combat human infectious diseases

Matić

Šantak

2021

Appl Microbiol Biotechnol

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Inactivated and live attenuated vaccines have improved human life and significantly reduced morbidity and mortality of several human infectious diseases. However, these vaccines have faults, such as reactivity or suboptimal efficacy and expensive and time-consuming development and production. Additionally, despite the enormous efforts to develop vaccines against some infectious diseases, the traditional technologies have not been successful in achieving this. At the same time, the concerns about emerging and re-emerging diseases urge the need to develop technologies that can be rapidly applied to combat the new challenges. Within the last two decades, the research of vaccine technologies has taken several directions to achieve safe, efficient, and economic platforms or technologies for novel vaccines. This review will give a brief overview of the current state of the novel vaccine technologies, new vaccine candidates in clinical trial phases 1-3 (listed by European Medicines Agency (EMA) and Food and Drug Administration (FDA)), and vaccines based on the novel technologies which have already been commercially available (approved by EMA and FDA) with the special reference to pandemic COVID-19 vaccines. Key points• Vaccines of the new generation follow the minimalist strategy.• Some infectious diseases remain a challenge for the vaccine development.• The number of new vaccine candidates in the late phase clinical trials remains low.

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“…Correspondingly, baculoviruses developed multiple strategies to antagonize these defence systems (figure 1, C). A recent review also summarizes research progress on the interactions between baculoviruses and host immune systems [38].…”

Section: Modulation Of Host Defence Systemsmentioning

confidence: 99%

Cross-talking between baculoviruses and host insects towards a successful infection

Wang

2019

Phil. Trans. R. Soc. B

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Baculoviridae is a family of large DNA viruses that infect insects. They have been extensively used as safe and efficient biological agents for the control of insect pests. As a result of coevolution with their hosts, baculoviruses developed unique life cycles characterized by the production of two distinctive virion phenotypes, occlusion-derived virus and budded virus, which are responsible for mediating primary infection in insect midgut epithelia and spreading systemic infection within infected insects, respectively. In this article, advances associated with virus -host interactions during the baculovirus life cycle are reviewed. We mainly focus on how baculoviruses exploit versatile strategies to overcome diverse host barriers and establish successful infections. For example, in the midgut, baculoviruses encode enzymes to degrade peritrophic membranes and use a series of per os infectivity factors to initiate primary infection. A viral fibroblast growth factor is expressed to attract tracheoblasts that spread the virus for systemic infection. Baculoviruses use different strategies to suppress host defence systems, including apoptosis, melanization and RNA interference. Additionally, baculoviruses can manipulate host physiology and induce 'tree-top disease' for optimal virus replication and dispersal. These advances in our understanding of baculoviruses will greatly inform the development of more effective baculoviral pesticides.This article is part of the theme issue 'Biotic signalling sheds light on smart pest management'.

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The interaction between baculoviruses and their insect hosts

Cited by 27 publications

References 141 publications

Neuropeptidome regulation after baculovirus infection. A focus on proctolin and its relevance in locomotion and digestion

Neuropeptidome regulation after baculovirus infection. A focus on proctolin and its relevance in locomotion and digestion

Current view on novel vaccine technologies to combat human infectious diseases

Cross-talking between baculoviruses and host insects towards a successful infection

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