The Interaction Between Amphiphilic Polymer Materials and Guest Molecules: Selective Adsorption and Its Related Applications

Yu, Bing; Jiang, Xuesong; Yin, Jie

doi:10.1002/macp.201400389

Cited by 6 publications

(3 citation statements)

References 62 publications

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“…Recently, experimental studies have been performed on adsorption associated with hydrogel delivery systems as a classic drug‐loading process39, 40 and as a strategy to provide multiple drug‐release rates,41 but none of them considered a rationally derived model of adsorption. Here, we study the release of ethosuximide (ESM), a succinimide anticonvulsant commonly used in epilepsy,42, 43 through agar‐carbomer‐based hydrogels (AC), which have already been studied and characterized for central‐nervous‐system applications 44–46.…”

Section: Introductionmentioning

confidence: 99%

Drug–Polymer Interactions in Hydrogel‐based Drug‐Delivery Systems: An Experimental and Theoretical Study

et al. 2015

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In drug-delivery systems, drug transport is a key step, but the interpretation of the transport mechanism is still controversial. Here, we investigated a promising hydrogel library loaded with the anticonvulsant drug ethosuximide (ESM). The self-diffusion coefficient of ESM was measured using two methods: a direct and advanced measurement with a pulsed field gradient spin-echo (PFGSE) method, using an NMR spectrometer equipped with high-resolution magic angle spinning (HR-MAS) probe, and an indirect one based on fitting in vitro drug-delivery data. Starting from the experimental data a mathematical model without fitted parameters was developed and all the phenomena involved, that is, adsorption and diffusion, were considered. At low drug concentrations, adsorption prevails and consequently the diffusivity in the gels is lower than that in water. At high drug concentrations, where all adsorption sites are saturated, the diffusion in the gels is similar to that in a water solution. This study may pave the way for better device design.

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Section: Introductionmentioning

confidence: 99%

Drug–Polymer Interactions in Hydrogel‐based Drug‐Delivery Systems: An Experimental and Theoretical Study

et al. 2015

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“…Amphiphilic hyperbranched poly(ether amine) containing coumarin and carboxyl groups (SA-hPEA-EC) was synthesized according to previous reports ,, (Figure a and Scheme S1 (Supporting Information). SA-hPEA-EC was directly dispersed into an aqueous solution to form a semitransparent solution at a concentration of 10 mg/mL.…”

Section: Methodsmentioning

confidence: 99%

Supramolecular Networks of Hyperbranched Poly(ether amine) (hPEA) Nanogel/Chitosan (CS) for the Selective Adsorption and Separation of Guest Molecules

et al. 2015

Macromolecules

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Supramolecular networks with selective adsorption for guest molecules were formed via dynamic hydrogenbonding interactions between the carboxyl group-containing hyperbranched poly(ether amine) nanogels (hPEA-NG) and chitosan (CS). The hPEA-NG/CS supramolecular networks were physically cross-linked and were composed of hPEA-NGs dispersed within a crystallized CS matrix. An increasing CS content enhanced the mechanical properties of the hPEA-NG/ CS supramolecular networks. The transparent hPEA-NG supramolecular networks did not disassemble in aqueous solutions with different pH values and organic solvents and were swollen with high weight fractions of water (W H 2 O = 0.95) in less than 30 s. The adsorptive behavior of seven fluorescein dyes and five azobenzene (azo) dyes onto the hPEA-NG/CS supramolecular networks was investigated. These hPEA-NG/CS supramolecular networks showed rapid adsorption for Rose Bengal (RB), Erythrosin B (ETB), Eosin B (EB), 4′,5′-dibromofluorescein (DBF), Ponceau S (PS) and Evans blue (EVB) dyes with high adsorption capacities (Q eq ). The networks showed very low adsorption for calcein (Cal), fluorescein (FR), 4,5,6,7-tetrachlorofluorescein (TCF), and Bismarck brown (BBY) dyes. The adsorption process was found to follow pseudo-second-order kinetics. The different adsorptive behaviors for different dyes indicated the selective adsorption of the hPEA-NG/CS supramolecular networks for the azo and fluorescein dyes despite similar backbone structures and charge states. On the basis of the unique selective adsorption, the separation of mixtures of fluorescein dyes, such as RB/Cal, RB/FR, and PS/MR, was achieved using the hPEA-NG/CS supramolecular network as an adsorbent. ■ INTRODUCTIONSupramolecular polymer networks are cross-linked threedimensional assemblies with noncovalent and intermolecular bonds. 1−4 They have gained considerable attention because of their intrinsic self-healing, 5,6 shape memory, 6−8 and stimuliresponse properties 6 and potential applications in controlled drug delivery, 9,10 and smart materials and water treatment. 11,12 The supramolecular polymer networks are typically cross-linked by transient physical interactions, including hydrogen bonding, 13−20 halogen bonding, 14,21 ionic interactions, 3,22 host− guest interactions, 23,24 π−π stacking, 13,25−28 and transition metal complexation. 29−31 Because of the directional property and versatility, the supramolecular interaction via hydrogen bonding has been intensively studied in the construction of supramolecular polymer networks. Lehn and co-workers generated mesoscopic molecules by the assembly of bifunctional heterocyclic chiral and achiral organic compounds (as the backbone) and uracil derivatives (as side-chains) through hydrogen bonds. 32 Using triuret blocks, controlled conformation and temperature-dependent hydrogen bonding, Ni and coworkers prepared supramolecular thermo-reversible polyureaurethane networks. 33 In these studies, the building blocks were usually polymers or oligomers. However, nanogels (NGs) as ...

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“…During the past ten years, polymer nanocarriers have attracted considerable attention because of their potential application in controlled drug delivery systems. − Perfect polymer nanocarriers are expected to efficiently traffic to the desired focus and conveniently release the drug into targeted cells. An effective approach is to incorporate sensitive moieties that can be cleaved upon stimuli, such as pH changes, − redox reactions, − and light irradiations, − at the side group of the hydrophobic block, leading to the novel strategies toward the preparation of dissociable amphiphilic polymer drug carriers.…”

Section: Introductionmentioning

confidence: 99%

Amphiphilic Polymer Micellar Disruption Based on Main-Chain Photodegradation

et al. 2015

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The amphiphilic block copolymer poly(ethylene oxide)-b-poly(N,N'-dihydroxypyromellitimide-hexamethylene diisocyanate) (PEO-b-PNH) with photocleavable N-O urethanes has been prepared to investigate the photodegradation of the hydrophobic main chain and therefore the disruption of copolymer micelles. Measurements of absorption and emission spectra, optical transmittance, DLS analysis, and TEM observations were applied. It was shown that PEO-b-PNH could self-assemble into flower compound micelles in water. The photodegradation of the hydrophobic polyurethane within the micellar core upon irradiation with 365 nm light could be conveniently controlled by changing the irradiation intensity; furthermore, complete micellar disruption could be achieved when 42% of N-O urethanes were photocleaved. By using DOX as the hydrophobic guest, the drug release profile showed a linear leakage of DOX out of the swelling polymer micelles in the initial stage and thereafter a much more quick exponential decay of DOX precipitation because of the micellar disruption upon further irradiation. The diffusion experiment of the leaked DOX into buffer solution (pH 7.4) showed that the DOX leakage could be prominently accelerated by a very short time of 365 nm irradiation, indicating that the N-O photocleavage can serve as a "turn-on" switch for the release of DOX in aqueous media.

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The Interaction Between Amphiphilic Polymer Materials and Guest Molecules: Selective Adsorption and Its Related Applications

Cited by 6 publications

References 62 publications

Drug–Polymer Interactions in Hydrogel‐based Drug‐Delivery Systems: An Experimental and Theoretical Study

Drug–Polymer Interactions in Hydrogel‐based Drug‐Delivery Systems: An Experimental and Theoretical Study

Supramolecular Networks of Hyperbranched Poly(ether amine) (hPEA) Nanogel/Chitosan (CS) for the Selective Adsorption and Separation of Guest Molecules

Amphiphilic Polymer Micellar Disruption Based on Main-Chain Photodegradation

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