The interaction between micro- and macrocracks in a fine-grained piezoelectric coating/substrate under remote antiplane mechanical and in-plane electrical loadings was studied. The principle of superposition and a mapping function method was used to transform the fine-grained coating/substrate structure containing the screw dislocation and the edge interfacial crack into the right semi-infinite plane piezoelectric bimaterial with screw dislocation to simplify the problem. Furthermore, the electric field, displacement field, intensity factors, and image force of these two problems were established. In addition, numerical calculations were then given graphically to study the effects of the elastic modulus of the material, the size of the crack, the thickness of the coating, and the screw dislocation angle on the edge interface crack and dislocation.