The interacting rotifer-biopolymers are anti- and disaggregating agents for human-type beta-amyloid in vitro

Datki, Zsolt; Balázs, Evelin; Gálik, Bence; Sinka, Rita; Zeitler, Lavinia; Bozsó, Zsolt; Kálmán, János; Hortobágyi, Tibor; Gálik-Oláh, Zita

doi:10.1016/j.ijbiomac.2021.12.184

Cited by 4 publications

(1 citation statement)

References 40 publications

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“…This proteinous multifunctional macromolecule may be a key component of the abovementioned catabolic and neurotoxic aggregate inactivation capacity. 33 Therefore, the aim of future research is to fully understand the different groups and types of Rotimers, and explore their molecular structure and possible translational and multifunctional applications. The related novel and interdisciplinary methodologies, the phenomenon of catabolism of aggregated proteins, the existence of Rotimers, and their pilot characterization were recently introduced.…”

Section: Possibilities Offered By Rotimers In Biomedicinementioning

confidence: 99%

Translational biomedicine-oriented exploratory research on bioactive rotifer-specific biopolymers

Datki¹,

Sinka²

2022

Adv Clin Exp Med

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There are numerous surprising discoveries in current comprehensive biopolymer research, including the description of new types of biopolymers and the extension of their applications. The discovery of a new rotiferspecific biopolymer family (Rotimers) and the exceptional ability of these micrometazoans to inactivate and catabolize human-type neurotoxic aggregates (e.g., beta-amyloids, alpha-synucleins, prions) by their exudates can be mentioned as the original work of our research group. Rotimers are exogenous and protein complex molecules with a calcium-dependent production mechanism in both bdelloid and monogonant rotifers. However, their experimental and application possibilities are still unknown; only part of the class has been explored and described. Current Rotimer-related studies present promising biodiversity and bioactivity of these biomaterials (e.g., anti-and disaggregation effects or high degrees of adhesion to other molecules). The primary objective of current research is to explore and develop their application in translational biomedicine. A key area is the design of drug candidates against neurodegeneration-related aggregates based on the molecular information provided by the composition, structure and function of Rotimers. These novel biomaterials have the potential to open new perspectives in the pharmaceutical industry and healthcare.

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Section: Possibilities Offered By Rotimers In Biomedicinementioning

confidence: 99%

Translational biomedicine-oriented exploratory research on bioactive rotifer-specific biopolymers

Datki¹,

Sinka²

2022

Adv Clin Exp Med

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Ultrastructure of the extraordinary pedal gland in Asplanchna aff. herricki (Rotifera: Monogononta)

Hochberg,

Wallace,

Walsh

et al. 2024

Journal of Morphology

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Rotifers possess complex morphologies despite their microscopic size and simple appearance. Part of this complexity is hidden in the structure of their organs, which may be cellular or syncytial. Surprisingly, organs that are cellular in one taxon can be syncytial in another. Pedal glands are widespread across Rotifera and function in substrate attachment and/or egg brooding. These glands are normally absent in Asplanchna, which lack feet and toes that function as outlets for pedal glandular secretions in other rotifers. Here, we describe the ultrastructure of a pedal gland that is singular and syncytial in Asplanchna aff. herricki, but is normally paired and cellular in all other rotifers. Asplanchna aff. herricki has a single large pedal gland that is active and secretory; it has a bipartite, binucleate, syncytial body and a cytosol filled with rough endoplasmic reticulum, Golgi, and several types of secretory vesicles. The most abundant vesicle type is large and contains a spherical electron‐dense secretion that appears to be produced through homotypic fusion of condensing vesicles produced by the Golgi. The vesicles appear to undergo a phase transition from condensed to decondensed along their pathway toward the gland lumen. Decondensation changes the contents to a mucin‐like matrix that is eventually exocytosed in a “kiss‐and‐run” fashion with the plasma membrane of the gland lumen. Exocytosed mucus enters the gland lumen and exits through an epithelial duct that is an extension of the syncytial integument. This results in mucus that extends from the rotifer as a long string as the animal swims through the water. The function of this mucus is unknown, but we speculate it may function in temporary attachment, prey capture, or floatation.

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Particle-dependent reproduction and exogenic biopolymer secretion of protozoa co-cultured rotifers

Datki

Sinka

Gálik

et al. 2022

International Journal of Biological Macromolecules

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The interacting rotifer-biopolymers are anti- and disaggregating agents for human-type beta-amyloid in vitro

Cited by 4 publications

References 40 publications

Translational biomedicine-oriented exploratory research on bioactive rotifer-specific biopolymers

Translational biomedicine-oriented exploratory research on bioactive rotifer-specific biopolymers

Ultrastructure of the extraordinary pedal gland in Asplanchna aff. herricki (Rotifera: Monogononta)

Particle-dependent reproduction and exogenic biopolymer secretion of protozoa co-cultured rotifers

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