The inter‐observer agreement in the assessment of carotid plaque neovascularization by contrast‐enhanced ultrasonography: The impact of plaque thickness

Chen, Jian; Zhang, Yanming; Song, Ze–Zhou; Fu, Yue; Yang, Geng

doi:10.1002/jcu.22595

Cited by 4 publications

(1 citation statement)

References 19 publications

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“…In the present study, the thickest plaque rather than plaque which caused the recurrence of IS was evaluated. However, previous studies have reported that the stability of the largest plaque is signi cantly related to the occurrence of cerebral infarcts [25,26]. Moreover, the present study was retrospective in nature and whether the conclusions drawn hold the same signi cance in the prospective study needs to be evaluated further.…”

Section: Limitationsmentioning

confidence: 77%

Diagnostic Utility of Combined 2D Ultrasonography and Contrast-Enhanced Ultrasonography in Evaluation of Carotid Plaque Vulnerability for Predicting Recurrent Ischemic Strokes

Yang

Liang

et al. 2021

Preprint

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Objective: To evaluate the sensitivity and specificity of combined 2D ultrasonography (USG) and contrast-enhanced ultrasonography (CEUS) in analyzing the carotid plaque vulnerability for predicting the recurrent ischemic strokes (IS). Methods: One hundred and fifteen patients with first IS were studied by 2D USG and CEUS. The carotid plaques were then classified on the basis of echogenicity (2D USG) and neovascularization (CEUS). The presence or absence of recurrent IS was considered as the dependent variable. Age, gender, body mass index (BMI), hypertension, hyperglycemia, hyperlipidemia, history of smoking and drinking, type of plaque echogenicity, and grade of plaque neovascularization were considered as independent variables. The risk factors of recurrent IS were analyzed by both univariate and multivariate logistic regression analysis. Finally, the sensitivity and specificity of combined 2D USG and CEUS in the diagnosis of recurrent IS was evaluated by receiver operating characteristic curve. Results: Univariate logistic regression analysis revealed that hypertension, echogenicity type, and grade of plaque neovascularization were predictors of recurrent IS. Further, multivariate logistic regression analysis revealed that the echogenicity type (OR=0.282, P=0.012) and grade of plaque neovascularization (OR=7.408, P<0.0001) were independent risk factors for recurrent IS. The sensitivity, specificity, and area under the curve of combined method were 0.865, 0.769, and 0.817, respectively (95%CI: 0.733-0.902, P<0.0001), which were higher than both 2D USG and CEUS.Conclusions: The echogenicity type and grade of plaque neovascularization are independent risk factors for recurrent IS. The combination of two methods has high sensitivity and specificity in predicting the recurrent IS.

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Section: Limitationsmentioning

confidence: 77%

Diagnostic Utility of Combined 2D Ultrasonography and Contrast-Enhanced Ultrasonography in Evaluation of Carotid Plaque Vulnerability for Predicting Recurrent Ischemic Strokes

Yang

Liang

et al. 2021

Preprint

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Intraplaque Microvascular Flow Signal in Superb Microvascular Imaging and Magnetic Resonance Imaging Carotid Plaque Imaging in Patients with Atheromatous Carotid Artery Stenosis

Hoshino

Shimizu

Ogura

et al. 2018

Journal of Stroke and Cerebrovascular Diseases

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Contrast enhanced ultrasound of carotid plaque in acute ischemic stroke (CUSCAS study)

et al. 2021

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The inter‐observer agreement in the assessment of carotid plaque neovascularization by contrast‐enhanced ultrasonography: The impact of plaque thickness

Abstract: The interobserver agreement for assessing carotid plaque neovascularization by using contrast-enhanced ultrasonography is substantial and acceptable for research purposes, regardless of the maximal thickness of the plaque.

Cited by 4 publications

References 19 publications

Diagnostic Utility of Combined 2D Ultrasonography and Contrast-Enhanced Ultrasonography in Evaluation of Carotid Plaque Vulnerability for Predicting Recurrent Ischemic Strokes

Diagnostic Utility of Combined 2D Ultrasonography and Contrast-Enhanced Ultrasonography in Evaluation of Carotid Plaque Vulnerability for Predicting Recurrent Ischemic Strokes

Intraplaque Microvascular Flow Signal in Superb Microvascular Imaging and Magnetic Resonance Imaging Carotid Plaque Imaging in Patients with Atheromatous Carotid Artery Stenosis

Contrast enhanced ultrasound of carotid plaque in acute ischemic stroke (CUSCAS study)

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