The Inter- and Intra-Tribal Distribution of Red Cell G6PD Phenotypes in Sudan

Abstract

1,416 males and 564 female subjects from four Negroid and five Arab tribes and a group of mixed tribes of the Sudan were investigated for the phenotypic distribution of red cell glucose-6-phosphate dehydrogenase by starch gel electrophoresis. In general, the tribes of Negroid origin had higher frequency of Gd^A compared to the tribes of Arab ancestry. However, the Nilotes showed a lower frequency of Gd^A allele and the Mahass tribe claiming an Arab origin had a higher frequency of Gd^A. The immigrant groups from the neighbouring African countries also had a higher frequency of Gd^A. Gd^B (Khartoum) was present in low frequencies in both the Arab and Negroid tribes. A great deal of intratribal variation in the phenotypic distribution of G6PD was observed in the Nuba and Gáali tribes from different localities

A Study of Some Blood Genetic Characteristics of Bedouin and Non-Bedouin Arabs of Jordan

“…The frequency of GdA was found to be very low (0.026 and 0.007) in both Bedouins and non-Bedouin Arabs of Jordan, which con firms our earlier observation. A similar low frequency of GdA has been reported in Saudi Bedouins (0.02) [Bayoumi et al, 1979;Samuel and Saha, unpublished] and North Sinai Bedouins (0.015) , A much higher frequency of GdA was reported in Sudanese Arabs [Saha et al, 1978[Saha et al, , 1983; and in a city population of North Sinai (0.045) . The frequency of Get in the present population was observed to be 0.069 in Bedouins and 0.047 in non-Bedouins, respectively, which is slightly higher than that observed in our earlier series of Jordanians (0.032) [ Banerjee et al, 1981].…”

“…A similar low fre quency of Gd' has been reported in the Bedouin Arabs of Saudi Arabia (0.02 and 0.05), and in Sudanese Arabs (0.03) [Bayoumi et al, 1979;Saha et al, 1983]. A somewhat higher frequency of Gd' (up to 0.08) was reported among the Bedouins of North Sinai , The rare hyperactive and slow-moving variant G d b(krt) originally detected among the Sudanese [Saha et al, 1978[Saha et al, , 1983 was not present in our earlier series of Jordanians. A low frequency of this allele was present in both groups.…”

“…The frequency of Get in the present population was observed to be 0.069 in Bedouins and 0.047 in non-Bedouins, respectively, which is slightly higher than that observed in our earlier series of Jordanians (0.032) [ Banerjee et al, 1981]. A similar low fre quency of Gd' has been reported in the Bedouin Arabs of Saudi Arabia (0.02 and 0.05), and in Sudanese Arabs (0.03) [Bayoumi et al, 1979;Saha et al, 1983]. A somewhat higher frequency of Gd' (up to 0.08) was reported among the Bedouins of North Sinai , The rare hyperactive and slow-moving variant G d b(krt) originally detected among the Sudanese [Saha et al, 1978[Saha et al, , 1983 was not present in our earlier series of Jordanians.…”

Association of Red Cell Glucose-6-Phosphate Dehydrogenase with Haemoglohinopathies

“…However, the frequency of this hyperactive Gd var iant has been found to be lower in the present series. The same allele had been detected in Jordanians [24] and in the Ni lotic, Negroid and Arab tribes of Sudan [25]. However, this new Gd allele is not as sociated with any haemoglobinopathies and as such no selective advantage is ex pressed.…”

Characterization of Glucose-6-Phosphate Dehydrogenase Variants in the Sudan – Including Gd^Khartoum, a Hyperactive Slow Variant

“…A more detailed electrophoretic study o f more than 2,000 Sudanese suggested that the Qjkhartoum varjant js not very uncomm on in the country [6], although less common than the G dA and deficient alleles (G dA~ and G dB"). The average activity of the QjKhartoum (n = 14) was foun(] to be signifi cantly higher (p < 0.001) than the common G d B variant [8].…”