The integrin αMβ2 anchors hematopoietic progenitors in the bone marrow during enforced mobilization

Hidalgo, Andrés; Peired, Anna Julie; Weiss, Linnea A.; Katayama, Yoshio; Frenette, Paul S.

doi:10.1182/blood-2003-10-3702

Cited by 41 publications

(35 citation statements)

References 54 publications

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“…Interestingly, a recent report has provided evidence that the retention of hemopoietic progenitor cells in the bone marrow is dependent on CD11b:CD18. 28 Indeed hemopoietic progenitor cell mobilization in response to a variety of factors was shown to be enhanced by CD11b blockade and in CD11b-deficient mice. 28 It is possible therefore that CD11b:CD18 plays a fundamental role in the retention of both immature and mature leukocytes within the bone marrow.…”

Section: Discussionmentioning

confidence: 99%

The CXC chemokine MIP-2 stimulates neutrophil mobilization from the rat bone marrow in a CD49d-dependent manner

Burdon

Martin

Rankin

2005

Blood

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The acute release of neutrophils from the bone marrow is a critical step in their trafficking to sites of inflammation. This process is stimulated by systemically acting inflammatory mediators, such as the CXC chemokines. In this study we have used a novel in situ perfusion system of the rat femoral bone marrow to directly investigate the role of specific adhesion molecules in chemokine-stimulated neutrophil mobilization. We show here that neutrophils mobilized in response to rat macrophage inflammatory protein-2 (MIP-2) shed L-selectin and expressed significantly higher levels of CD11b and CD49d. However, inhibition of L-selectin sheddase activity with KD-IX-73-4 had no effect on the number of neutrophils mobilized in response to rat MIP-2. Blockade of CD18, using a neutralizing monoclonal antibody (mAb), did not inhibit neutrophil mobilization but unexpectedly increased the rate and number of neutrophils released from the bone marrow in response to chemokine, suggesting that CD18 could play a role in neutrophil retention within the bone marrow. Blockade of CD49d using either a selective mAb or a specific antagonist resulted in a dramatic inhibition (> 75%) of the chemokine-stimulated neutrophil mobilization from the bone marrow. These data reveal contrasting roles for CD18 and CD49d in the retention and release of neutrophils from the bone marrow. (Blood. 2005;105:2543-2548)

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Section: Discussionmentioning

confidence: 99%

The CXC chemokine MIP-2 stimulates neutrophil mobilization from the rat bone marrow in a CD49d-dependent manner

Burdon

Martin

Rankin

2005

Blood

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“…Integrins are heterodimers of an ␣ and a ␤ chain, and a comparison of three independent cross system stem cell transcriptional profiling studies (Ivanova et al, 2002;Ramalho-Santos et al, 2002;Fortunel et al, 2003), found that the ␣ chain of the principal integrin laminin receptor ␣6␤1 was the only shared gene expressed in all stem cells. Disruption of integrin activity in the epidermal and hematopoietic niches resulted in compromised self-renewal (Frye et al, 2003;Scott et al, 2003;Hidalgo et al, 2004;Priestley et al, 2005). There could also be a role in HSC homing and engraftment as a recent report on mice with a targeted cdc42 deletion in hematopoietic cells showed a decrease in ␤1 integrin expression, with excess HSCs throughout the periphery and associated defects of HSC engrafting into bone marrow (Yang et al, 2007).…”

Section: Signaling In Adult Neural and Other Stem Cell Nichesmentioning

confidence: 99%

“…These signaling mechanisms may occur between stem cells, between support cells and stem cells, and between stem cells and differentiating cells. Cell/cell and cell/ECM adhesion and signaling in adult niches is mediated through cell adhesion receptors such as cadherins (Song et al, 2002;Zhang et al, 2003) and integrins (Jones and Watt, 1993;Shinohara et al, 1999;Suzuki et al, 2000;Fujimoto et al, 2002;Frye et al, 2003;Scott et al, 2003;Blanpain et al, 2004;Chen et al, 2004;Deb et al, 2004;Hidalgo et al, 2004;Corbel et al, 2005;Priestley et al, 2005;Wagers and Weissman, 2005;Bajanca et al, 2006;Pajoohesh-Ganji et al, 2006;Lawson et al, 2007;Yang et al, 2007). In this model, as a cell moves away from the niche and thus away from some regulatory signals, it adopts a differentiated phenotype as shown in the pair of cells to the right.…”

Section: Introductionmentioning

confidence: 99%

The microenvironment of the embryonic neural stem cell: Lessons from adult niches?

Lathia

Rao

Mattson

et al. 2007

Developmental Dynamics

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A better understanding of the signals regulating embryonic neural stem cells is clearly an important goal. However, many studies on neural stem cell biology are conducted on the slowly-dividing cells found in the adult CNS, where specialized microenvironments or niches maintain the stem cells throughout life. By contrast, the embryonic VZ is a transient structure that does not fulfill the criteria conventionally used to define niches. In this review we will examine whether, despite these differences, the signals found in other adult stem cell niches are present in the VZ. Using the similarities and differences we observe, we will reconsider whether the location of embryonic stem cell populations such as the VZ can be thought of as niches. Finally, we will ask how these lessons from the niche inform our understanding of neurodevelopmental diseases and cancers of the CNS. Developmental Dynamics 236:3267-3282, 2007.

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“…The insufficient adhesion of hemopoietic stem cells to BMSCs is associated with their mobilization and appearance in the circulation (52). To define whether the rapid disappearance of plasmablasts from the early-life BM compartment (Fig.…”

Section: Short Survival Of Plasmablasts In the Early-life Bm Compartmentmentioning

confidence: 99%

Reduced Ability of Neonatal and Early-Life Bone Marrow Stromal Cells to Support Plasmablast Survival

Pihlgren

Friedli

Tougne

et al. 2006

The Journal of Immunology

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In human infants (<1 year), circulating IgG Abs elicited in response to most T-dependent Ags rapidly decline and return to baseline within a few months after immunization for yet-unknown reasons. In mice immunized between 1 and 4 wk of age, a limited establishment of the bone marrow (BM) pool of long-lived plasma cells is observed. In this study, we show that tetanus toxoid (TT)-specific plasmablasts generated in the spleen are efficiently attracted in vitro and in vivo toward early-life BM stromal cells, which express adult levels of CXCL12. Similarly, adoptively transferred TT plasmablasts efficiently reach the BM compartment of 2-wk-old and adult mice. In contrast, TT plasmablasts fail to persist in the early-life BM compartment, as indicated by the persistence of a significantly lower number of TT plasmablasts in the early-life compartment than in the adult BM compartment 48 h after transfer. This limited persistence is associated with an increased rate of in vivo apoptosis of TT-specific plasmablasts that have reached the early-life BM and with a significantly lower survival rate of TT-specific plasmablasts cocultured on early-life BM stromal cells compared with adult BM stromal cells. Thus, early-life BM stromal cells fail to provide the molecular signals that support plasmablast survival and differentiation into surviving plasma cells.

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The integrin αMβ2 anchors hematopoietic progenitors in the bone marrow during enforced mobilization

Cited by 41 publications

References 54 publications

The CXC chemokine MIP-2 stimulates neutrophil mobilization from the rat bone marrow in a CD49d-dependent manner

The CXC chemokine MIP-2 stimulates neutrophil mobilization from the rat bone marrow in a CD49d-dependent manner

The microenvironment of the embryonic neural stem cell: Lessons from adult niches?

Reduced Ability of Neonatal and Early-Life Bone Marrow Stromal Cells to Support Plasmablast Survival

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