The Integration of Radiosurgery for the Treatment of Patients With Metastatic Spine Diseases

Sharan, Alok; Szulc, A; Krystal, Jonathan; Yassari, Reza; Laufer, Ilya; Bilsky, Mark H.

doi:10.5435/jaaos-22-07-447

Cited by 9 publications

(8 citation statements)

References 35 publications

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“…This provides the separation between the tumor and the spinal cord to provide safe and effective delivery of SRS postsurgery for local tumor control. With advances in technology, these surgeries can be done using minimal access and percutaneous fixation to minimize the morbidity of the procedure [12]. Radiotherapy, cEBRT or SRS, is required after surgery to achieve durable local tumor control [12,17]…”

Section: Evolution Of Treatmentmentioning

confidence: 99%

“…With advances in technology, these surgeries can be done using minimal access and percutaneous fixation to minimize the morbidity of the procedure [12]. Radiotherapy, cEBRT or SRS, is required after surgery to achieve durable local tumor control [12,17]…”

Section: Evolution Of Treatmentmentioning

confidence: 99%

“…With the advent of image guided stereotactic techniques, we now have the ability to target higher doses precisely on the tumor whilst sparing the spinal cord and other adjacent organs. Thus tumors that were traditional considered radioresistant can now be treated with SRS [12]. Even patients who have previously been treated with cEBRT are suitable candidates for SRS.…”

Section: Role Of Radiotherapymentioning

confidence: 99%

“…In these situations, the tumor and the spinal cord are in such close proximity that the requisite dose cannot be delivered to the tumor without risking spinal cord toxicity. Therefore, SRS is ideal for patient with radio-resistant metastasis without significant epidural extension of the tumor [12].…”

Section: Role Of Radiotherapymentioning

confidence: 99%

See 3 more Smart Citations

A multidisciplinary approach to the management of spinal metastasis: A review article

2021

JCOrth

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Spinal metastasis is a frequent occurrence in patients presenting with advanced malignancy. The burden of this condition is on rise, especially with the availability of aggressive treatment regimens for the primary disease and the improvement in the patient survival. Thoracic spine is the most affected region. The likely source of the primary is from the breast, prostate, lung, thyroid, or kidney. Certain hematological and other malignant conditions can also develop an early spinal involvement that requires timely evaluation and management. The goals for the management of the spinal lesion include preservation of the neurological function, pain control, and maintenance of spinal stability. On the whole, the aim of the treatment continues to palliation in majority of the scenarios. The management strategy is based on the factors that include the patient condition, life expectancy, nature of the tumor pathology, extent of spinal cord compression, severity of neurological deficit, pain control, and the effect on spinal stability. A multidisciplinary approach involving medical oncology, radiation oncology, spine surgery, palliative care and other subspecialtiess forms the cornerstone of the management. Although giant strides have been reported in the advancement of the treatment for spinal metastasis, majority of these avenues are beyond the reach of the patient population from the developing societies. Lack of referral facilities, resource constraints, and geographic disparities are major impediments. The lack of awareness and consensus on the management protocols within the treatment team and the medical community in general poses another challenge in providing an acceptable standard of care. This article offers an insight into the principles that guide the management of spinal metastasis. The application of these principles in the background of the resource constraints that are unique to the South Asian population has also been addressed. This is a synopsis on the mu

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Section: Evolution Of Treatmentmentioning

confidence: 99%

Section: Evolution Of Treatmentmentioning

confidence: 99%

Section: Role Of Radiotherapymentioning

confidence: 99%

Section: Role Of Radiotherapymentioning

confidence: 99%

See 2 more Smart Citations

A multidisciplinary approach to the management of spinal metastasis: A review article

2021

JCOrth

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“…One representative case of this type of approach can be found in the development of orthopaedic screws for improved imaging of spine tumours. One of the most used and effective methods to treat spine tumours is the combination of radiotherapy and surgery [22]. However, conventional pedicle titanium screws can lead to the creation of imaging artefacts, due to radiation scattering, which can in turn limit the dose of radiation used and difficult the imaging of the irradiated area, reducing treatment efficacy.…”

Section: Taking a Step Back -Refocusing Innovation On Clinical Needsmentioning

confidence: 99%

Translational Research Symposium—collaborative efforts as driving forces of healthcare innovation

Coentro

Pieri

Gaspar

et al. 2019

J Mater Sci: Mater Med

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The 5th Translational Research Symposium was organised at the annual meeting of the European Society for Biomaterials 2018, Maastricht, the Netherlands, with emphasis on the future of emerging and smart technologies for healthcare in Europe. Invited speakers from academia and industry highlighted the vision and expectations of healthcare in Europe beyond 2020 and the perspectives of innovation stakeholders, such as small and medium enterprises, large companies and Universities. The aim of the present article is to summarise and explain the main statements made during the symposium, with particular attention on the need to identify unmet clinical needs and their efficient translation into healthcare solutions through active collaborations between all the participants involved in the value chain.

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Carbon-fiber-reinforced PEEK fixation system in the treatment of spine tumors: a preliminary report

et al. 2017

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No artifacts on imaging studies mean early local recurrence detection. For radiation oncologists, no artifacts on imaging studies mean easier planning and no scattering effect means more effective and safe radiotherapy, particularly when particles are used. Moreover, it seems that the clinical use of CFR-PEEK composite implants may be safe and at least comparable with the commonly used titanium implants in terms of intraoperative complications, stability at weight bearing and at functional recovery. Larger patient series and longer follow-up are required to confirm these data.

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The Integration of Radiosurgery for the Treatment of Patients With Metastatic Spine Diseases

Cited by 9 publications

References 35 publications

A multidisciplinary approach to the management of spinal metastasis: A review article

A multidisciplinary approach to the management of spinal metastasis: A review article

Translational Research Symposium—collaborative efforts as driving forces of healthcare innovation

Carbon-fiber-reinforced PEEK fixation system in the treatment of spine tumors: a preliminary report

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