The Integration of Prosodic Speech in High Functioning Autism: A Preliminary fMRI Study

Abstract

BackgroundAutism is a neurodevelopmental disorder characterized by a specific triad of symptoms such as abnormalities in social interaction, abnormalities in communication and restricted activities and interests. While verbal autistic subjects may present a correct mastery of the formal aspects of speech, they have difficulties in prosody (music of speech), leading to communication disorders. Few behavioural studies have revealed a prosodic impairment in children with autism, and among the few fMRI studies aiming at assessing the neural network involved in language, none has specifically studied prosodic speech. The aim of the present study was to characterize specific prosodic components such as linguistic prosody (intonation, rhythm and emphasis) and emotional prosody and to correlate them with the neural network underlying them.Methodology/Principal FindingsWe used a behavioural test (Profiling Elements of the Prosodic System, PEPS) and fMRI to characterize prosodic deficits and investigate the neural network underlying prosodic processing. Results revealed the existence of a link between perceptive and productive prosodic deficits for some prosodic components (rhythm, emphasis and affect) in HFA and also revealed that the neural network involved in prosodic speech perception exhibits abnormal activation in the left SMG as compared to controls (activation positively correlated with intonation and emphasis) and an absence of deactivation patterns in regions involved in the default mode.Conclusions/SignificanceThese prosodic impairments could not only result from activation patterns abnormalities but also from an inability to adequately use the strategy of the default network inhibition, both mechanisms that have to be considered for decreasing task performance in High Functioning Autism.

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“…Although both ASD and neurotypical controls showed equivalent behavioral performance, the ASD group showed greater activity in the right inferior frontal gyrus, suggesting an atypical and potentially compensatory neural mechanism in individuals with ASD. A second study of pragmatic language processing found that adults with ASD showed increased activity in the left supramarignal gyrus compared with controls (Hesling et al, 2010). Several other investigations have focused on the neural correlates of prosodic cues in ASD by examining brain activity during processing of ironic vs sincere speech.…”

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