The integrated analysis and underlying mechanisms of FNDC5 on diabetic induced cognitive deficits
Qiong Xiang,
Jia‐Sheng Tao,
Chuan‐Jun Fu
et al.
Abstract:ObjectivesChronic hyperglycemia is considered as an important factor to promote the neurodegenerative process of brain, and the synaptic plasticity as well as heterogeneity of hippocampal cells are thought to be associated with cognitive dysfunction in the early process of neurodegeneration. To date, fibronectin type III domain‐containing protein 5 (FNDC5) has been highlighted its protective role in multiple neurodegenerative diseases. However, the potential molecular and cellular mechanisms of FNDC5 on synapt… Show more
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