The intake of water containing a mix of pollutants at environmentally relevant concentrations leads to defensive response deficit in male C57Bl/6J mice

Souza, Joyce Moreira de; Rabelo, Letícia Martins; Faria, Denise Braga Gomes de; Guimarães, Abraão Tiago Batista; Silva, Wellington Alves Mizael da; Rocha, Thiago Lopes; Estrela, Fernanda Neves; Chagas, Thales Quintão; Mendes, Bruna de Oliveira; Malafaia, Guilherme

doi:10.1016/j.scitotenv.2018.02.040

Cited by 18 publications

(2 citation statements)

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“…It is obviously that the risks of chemical pollutants are mostly evaluated on the single toxicity value of a chemical and the adverse effects or single actions of chemicals have received extensive attention [1,2,3,4]. Although it is crucial to identify and characterize harmful effects from pollutants on different organisms, it is incontestable that those results are not enough to tell what happens in the real environment [5]. After all, contaminants are introduced into the aquatic ecosystems as complex blends.…”

Section: Introductionmentioning

confidence: 99%

“…After all, contaminants are introduced into the aquatic ecosystems as complex blends. When the chemicals collectively exist, it is worth taking into account that certain pollutant combinations may interact and result in different interactions toxic effects on ecosystems or organisms [5,6]. Interactions of components in a mixture can cause complex and substantial changes in the apparent properties of its constituents [7].…”

Section: Introductionmentioning

confidence: 99%

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Combined Toxicity of Nitro-Substituted Benzenes and Zinc to Photobacterium Phosphoreum: Evaluation and QSAR Analysis

Zhang

et al. 2019

IJERPH

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The single toxicity (IC50) of zinc (Zn) and 11 nitro-substituted benzenes to Photobacterium phosphoreum were determined, respectively. On basis of single toxicity, the joint toxicity of binary mixtures of Zn and 11 nitro-substituted benzenes at different Zn concentrations of 0.2 IC50, 0.5 IC50, and 0.8 IC50 were measured. The joint toxicity was evaluated by toxic unit (TU) and additive index (AI) methods. The results indicated that the joint toxicity was not only depending on the Zn concentrations but also on the substituted groups of nitro-substituted benzenes. The quantitative structure-activity relation (QSAR) equations were developed and the results showed that the toxicity of nitro-substituted benzenes has different joint effect at the different Zn concentrations. At the Zn concentration of 0.2 IC50, the binary joint effects were mainly antagonism and the joint toxicity was negatively related to descriptors called VE2_B(p) and TIC3. At the Zn concentration of 0.5 IC50 and 0.8 IC50, the binary joint effects were mainly antagonism and simple addition, and the joint toxicity was related to the same descriptor Eig06_ AEA(dm). It indicated that the joint toxic actions were similar when combined at the medium and high concentrations of Zn.

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