The Insulin Resistance Syndrome in Native Hawaiians

Mk, Mau; Grandinetti, Andrew; Rf, Arakaki; Chang, HK; Ek, Kinney; Jd, Curb

doi:10.2337/diacare.20.9.1376

Cited by 32 publications

(13 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The study methods of the NHHR Project have been described previously (4) and are summarized here. The NHHR Project was conducted in partnership with existing native Hawaiian health care organizations in the communities of North Kohala, on the island of Hawaii, and Waimea/Kehaha, on the island of Kauai.…”

Section: Research Design a N D Methods-mentioning

confidence: 99%

Prevalence of Glucose Intolerance Among Native Hawaiians in Two Rural Communities

et al. 1998

Self Cite

View full text Add to dashboard Cite

This study observed a high prevalence of glucose intolerance associated with being overweight among native Hawaiians. Age-adjusted type 2 diabetes prevalence was four times higher than among the U.S. National Health and Nutrition Examination Survey (NHANES) II population. Prevalence was high despite high rates of admixture with other ethnic groups of Hawaii, suggesting that these other Asian and Pacific Island populations share similar susceptibility to type 2 diabetes risk.

show abstract

Section: Research Design a N D Methods-mentioning

confidence: 99%

Prevalence of Glucose Intolerance Among Native Hawaiians in Two Rural Communities

et al. 1998

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, this study excluded non-Asian/Pacific Islander/Filipino patients and the data were limited to only a one-year period. Since several Asian American and Pacific Islander subgroups in Hawaii have a higher burden of risk factors for preeclampsia, including chronic hypertension, diabetes, obesity (Curb et al, 1991; Mau et al, 1997; Mau, Sinclair, Saito, Baumhofer, & Kaholokula, 2009; Moy, Sallis, & David) and other cardiovascular disease-related complications (Aluli, Reyes, & Tsark, 2007; J. Balabis, 2007), we hypothesized that these groups have higher risk of preeclampsia compared to whites.…”

Section: Introductionmentioning

confidence: 99%

Racial/Ethnic Disparities in the Association Between Preeclampsia Risk Factors and Preeclampsia Among Women Residing in Hawaii

Nakagawa

Lim

Harvey

et al. 2016

Matern Child Health J

View full text Add to dashboard Cite

Objective To assess differences in the rates of preeclampsia among a multiethnic population in Hawaii. Methods We performed a retrospective study on statewide inpatient data for delivery hospitalizations in Hawaii between January 1995 and December 2013. Multivariable logistic regression was used to assess the impact of maternal race/ethnicity on the rates of preeclampsia after adjusting for age, multiple gestation, multiparity, chronic hypertension, pregestational diabetes, obesity and smoking. Results A total of 271,569 hospital discharges for delivery were studied. The rates of preeclampsia ranged from 2.0% for Chinese to 4.6% for Filipinos. Preeclampsia rates were higher among Native Hawaiians who are age <35 and non-obese (OR, 1.54; 95% CI, 1.43-1.66), age ≥35 and non-obese (OR, 2.31; 95% CI, 2.00-2.68), age ≥35 and obese (OR, 1.80; 95% CI, 1.24-2.60); other Pacific Islanders who are age <35 and non-obese (OR, 1.40; 95% CI, 1.27-1.54), age ≥35 and non-obese (OR, 2.18; 95% CI, 1.79-2.64), age ≥35 and obese (OR, 1.68; 95% CI, 1.14-2.49); and Filipinos who are age <35 and non-obese (OR, 1.55; 95% CI, 1.43-1.67), age ≥35 and non-obese (OR, 2.26; 95% CI, 1.97-2.60), age ≥35 and obese (OR, 1.64; 95% CI, 1.04-2.59) compared to whites. Pregestational diabetes (OR, 3.41; 95% CI, 3.02-3.85), chronic hypertension (OR, 5.98; 95% CI, 4.98-7.18), and smoking (OR, 1.19; 95% CI, 1.07-1.33) were also independently associated with preeclampsia. Conclusion In Hawaii, Native Hawaiians, other Pacific Islanders and Filipinos have a higher risk of preeclampsia compared to whites. For these high-risk ethnic groups, more frequent monitoring for preeclampsia may be needed.

show abstract

“…[9], [10], [11], [12], [13], [14] Native Hawaiians have increased rates of obesity, a higher prevalence of diabetes, higher serum cholesterol and the highest cardiovascular mortality rate of any group in Hawaii. [15], [16], [17] The overall age- and gender-specific mortality rates due to heart disease are 66% greater in Native Hawaiians than Caucasians in the state. [18] …”

Section: Introductionmentioning

confidence: 99%

Established Risk Factors Account for Most of the Racial Differences in Cardiovascular Disease Mortality

et al. 2007

View full text Add to dashboard Cite

BackgroundCardiovascular disease (CVD) mortality varies across racial and ethnic groups in the U.S., and the extent that known risk factors can explain the differences has not been extensively explored.MethodsWe examined the risk of dying from acute myocardial infarction (AMI) and other heart disease (OHD) among 139,406 African-American (AA), Native Hawaiian (NH), Japanese-American (JA), Latino and White men and women initially free from cardiovascular disease followed prospectively between 1993–1996 and 2003 in the Multiethnic Cohort Study (MEC). During this period, 946 deaths from AMI and 2,323 deaths from OHD were observed. Relative risks of AMI and OHD mortality were calculated accounting for established CVD risk factors: body mass index (BMI), hypertension, diabetes, smoking, alcohol consumption, amount of vigorous physical activity, educational level, diet and, for women, type and age at menopause and hormone replacement therapy (HRT) use.ResultsEstablished CVD risk factors explained much of the observed racial and ethnic differences in risk of AMI and OHD mortality. After adjustment, NH men and women had greater risks of OHD than Whites (69% excess, P<0.001 and 62% excess, P = 0.003, respectively), and AA women had greater risks of AMI (48% excess, P = 0.01) and OHD (35% excess, P = 0.007). JA men had lower risks of AMI (51% deficit, P<0.001) and OHD (27% deficit, P = 0.001), as did JA women (AMI, 37% deficit, P = 0.03; OHD, 40% deficit, P = 0.001). Latinos had underlying lower risk of AMI death (26% deficit in men and 35% in women, P = 0.03).ConclusionKnown risk factors explain the majority of racial and ethnic differences in mortality due to AMI and OHD. The unexplained excess in NH and AA and the deficits in JA suggest the presence of unmeasured determinants for cardiovascular mortality that are distributed unequally across these populations.

show abstract

The Insulin Resistance Syndrome in Native Hawaiians

Abstract: This study provides cross-sectional data confirming the existence of the IRS in native Hawaiians. However, further longitudinal studies are needed to examine the relationship of insulin resistance and/or surrogate markers to increased rates of NIDDM and CVD mortality in native Hawaiians.

Cited by 32 publications

References 26 publications

Prevalence of Glucose Intolerance Among Native Hawaiians in Two Rural Communities

Prevalence of Glucose Intolerance Among Native Hawaiians in Two Rural Communities

Racial/Ethnic Disparities in the Association Between Preeclampsia Risk Factors and Preeclampsia Among Women Residing in Hawaii

Established Risk Factors Account for Most of the Racial Differences in Cardiovascular Disease Mortality

Contact Info

Product

Resources

About