The insular cortex and cardiovascular system: a new insight into the brain-heart axis

Nagai, Michiaki; Hoshide, Satoshi

doi:10.1016/j.jash.2010.05.001

Cited by 265 publications

(216 citation statements)

References 37 publications

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“…Other regions showing significant associations in the current analysis have been reported to be related to autonomic activity in previous studies [43]. In fact, the insular cortex is posited to act as an integrator on the brain-heart axis [48]: it has a prominent role in limbic-autonomic integration and is involved in the perception of emotional significance [49]; it also participates in visceral motor regulation, including blood pressure control, in cooperation with subcortical autonomic centres [50][51][52]. The dACC is also involved in autonomic control [30,53]; the network consisting of insula, dACC and amygdala has been described as crucial in the regulation of central ANS [54].…”

Section: Discussionsupporting

confidence: 62%

Sensitivity of the resting-state haemodynamic response function estimation to autonomic nervous system fluctuations

Marinazzo

2016

Phil. Trans. R. Soc. A.

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Section: Discussionsupporting

confidence: 62%

Sensitivity of the resting-state haemodynamic response function estimation to autonomic nervous system fluctuations

Marinazzo

2016

Phil. Trans. R. Soc. A.

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“…In terms of the link between annual increases in resting HR and higher ADNP, the directionality of this relationship is unclear and it is possible that increased resting HR is secondary to a change in central and autonomic control over time that is influenced by brain regions damaged by age-or AD-related pathological changes. For example, the insular cortex is believed to play a role in the regulation of the cardiovascular system (47), and this brain region can be affected by ADNP before symptom onset (48,49). Alternatively, increased HR may contribute to the development of ADNP.…”

Section: Discussionmentioning

confidence: 99%

Late-Life Vascular Risk Factors and Alzheimer Disease Neuropathology in Individuals with Normal Cognition

Besser

Alosco

Gómez

et al. 2016

J Neuropathol Exp Neurol

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Vascular risk factors (VRFs) have been associated with clinically diagnosed Alzheimer disease (AD), but few studies have examined the association between VRF and AD neuropathology (ADNP) in cognitively normal individuals. We used longitudinal data from the National Alzheimer's Disease Center's Uniform Data Set and Neuropathology Data Set to examine the association between VRF and ADNP (moderate to frequent neuritic plaques; Braak stage III-VI) in those with normal cognition. Our sample included 53 participants with ADNP and 140 without ADNP. Body mass index (BMI), resting heart rate (HR), and pulse pressure (PP) were measured at each visit; values were averaged across participant visits and examined annual change in BMI, PP, and HR. Hypertension, diabetes, and hypercholesterolemia were self-reported. In the multivariable logistic regression analyses, average BMI and HR were associated with lower odds of ADNP, and annual increases in HR and BMI were associated with higher odds of ADNP. A previously experienced decline in BMI or HR in late-life (therefore, currently low BMI and low HR) as well as a late-life increase in BMI and HR may indicate underlying AD pathology. Additional clinicopathological research is needed to elucidate the role of changes in late-life VRF and AD pathogenesis.

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“…While right insular stimulation activates the sympathetic cardiovascular tone, the left insular stimulation activates the parasympathetic one (Oppenheimer 2006). It is worth, however to indicate that no clear predominant laterality on CVC or stroke prognosis in relation to insular cortex stroke has been reported in patients (Nagai et al 2010). On the other hand, under stress, heart disease correlates with an asymmetric hyperactivation of certain brain areas such as the left parietal cortex or the right visual association cortex (Soufer et al 1998).…”

Section: Asymmetry In the Neuroendocrine Interaction For The Cardiovamentioning

confidence: 94%

Bidirectional asymmetry in the neurovisceral communication for the cardiovascular control: New insights

Prieto

Segarra

Martı́nez-Cañamero

et al. 2017

Endocrine Regulations

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Th e cardiovascular control involves a bidirectional functional connection between the brain and heart. We hypothesize that this connection could be extended to other organs using endocrine and autonomic nervous systems (ANS) as communication pathways. Th is implies a neuroendocrine interaction controlling particularly the cardiovascular function where the enzymatic cascade of the renin-angiotensin system (RAS) plays an essential role. It acts not only through its classic endocrine connection but also the ANS. In addition, the brain is functionally, anatomically, and neurochemically asymmetric. Moreover, this asymmetry goes even beyond the brain and it includes both sides of the peripheral nervous and neuroendocrine systems. We revised the available information and analyze the asymmetrical neuroendocrine bidirectional interaction for the cardiovascular control. Negative and positive correlations involving the RAS have been observed between brain, heart, kidney, gut, and plasma in physiologic and pathologic conditions. Th e central role of the peptides and enzymes of the RAS within this neurovisceral communication, as well as the importance of the asymmetrical distribution of the various RAS components in the pathologies involving this connection, are particularly discussed. In conclusion, there are numerous evidences supporting the existence of a neurovisceral connection with multiorgan involvement that controls, among others, the cardiovascular function. Th is connection is asymmetrically organized.

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The insular cortex and cardiovascular system: a new insight into the brain-heart axis

Cited by 265 publications

References 37 publications

Sensitivity of the resting-state haemodynamic response function estimation to autonomic nervous system fluctuations

Sensitivity of the resting-state haemodynamic response function estimation to autonomic nervous system fluctuations

Late-Life Vascular Risk Factors and Alzheimer Disease Neuropathology in Individuals with Normal Cognition

Bidirectional asymmetry in the neurovisceral communication for the cardiovascular control: New insights

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