The Inspiratory Capacity To Total Lung Capacity Ratio Is Associated With Survival In Patients With Chronic Obstructive Pulmonary Disease

French, Aimee N.; Balfe, David; Falk, Jeremy A.; Mosenifar, Zab

doi:10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4564

Cited by 2 publications

(3 citation statements)

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“…Air trapping predict exercise capacity decline in COPD [11], COPD hospitalisations [12], and survival in an emphysematous phenotype of chronic obstructive pulmonary disease [13].…”

Section: Discussionmentioning

confidence: 99%

Utility Inspiratory Capacity by Simple Spirometry as an indirect Measure of Air Trapping

Herrejón¹,

Palop²,

Herrera³

et al. 2017

Arch Pulmonol Respir Care

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Objective: To evaluate the utility of inspiratory capacity (IC) measured by simple spirometry as an indirect measure of air trapping. Method:Functional residual capacity (FRC) and IC were determined, respectively, by a body plethysmography and by spirometry. Air trapping was defi ned by a FRC higher than 120%. Spearman's rho between IC and FRC is determined and the receiver operating characteristic (ROC curve) is calculated as predictive of air trapping for IC. The best cutoff of the overall test is calculated.Results: 148 patients were included with a mean FEV1 60% (SD 20%). There was signifi cant correlation between IC and FRC with a Spearman rho -0.673 (p <0.0001). The area under the ROC curve for IC and FRC was 0.803 (95% CI 0.709 to 0.897). The optimal cutoff for predicting air trapping was given for a forced IC less than 80% of its theoretical value, with a sensitivity of 82%, a specifi city of 73%, a positive predictive value of 73% and a negative predictive value 82%. Conclusions:Inspiratory capacity is useful in the assessment of air trapping and may determine a cut below 80%.

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“…Air trapping predict exercise capacity decline in COPD [11], COPD hospitalisations [12], and survival in an emphysematous phenotype of chronic obstructive pulmonary disease [13].…”

Section: Discussionmentioning

confidence: 99%

Utility Inspiratory Capacity by Simple Spirometry as an indirect Measure of Air Trapping

Herrejón¹,

Palop²,

Herrera³

et al. 2017

Arch Pulmonol Respir Care

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“…Tidal EFL leads to dynamic hyperinflation during exercise in patients with COPD as reflected by reduced inspiratory capacity (IC) and increased residual volume (RV), resulting in exercise intolerance [10]- [13]. Others have shown that the ratio of IC to total lung capacity (IC/TLC) is an independent predictor of mortality in patients with COPD [14]- [16]. In particular, in patients with the emphysematous phenotype of COPD an IC/ TLC ratio of <25% is a significant predictor for mortality (hazard ratio 2.4, p < 0.0001) [16].…”

Section: Introductionmentioning

confidence: 99%

“…Others have shown that the ratio of IC to total lung capacity (IC/TLC) is an independent predictor of mortality in patients with COPD [14]- [16]. In particular, in patients with the emphysematous phenotype of COPD an IC/ TLC ratio of <25% is a significant predictor for mortality (hazard ratio 2.4, p < 0.0001) [16]. Hyperinflation and its relation to morbidity and exercise intolerance have been assessed in children with CF [2], but not in adult CF patients.…”

Section: Introductionmentioning

confidence: 99%

Lung Hyperinflation Is Associated with Pulmonary Exacerbations in Adults with Cystic Fibrosis

Seng¹,

Fukushima²,

Patel³

et al. 2016

OJRD

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Background: Forced expiratory volume 1 second (FEV1) has traditionally been used as a readily available marker of health in adult cystic fibrosis (CF). However, due to the obstructive nature of this disease, it is possible that lung hyperinflation could be more closely related to disease severity than is FEV1. The purpose of this study was to determine if hyperinflation is more closely associated with quality of life, functional status, and pulmonary exacerbations than FEV1 in patients with CF. Methods: Sixty-eight adult patients with CF were evaluated in this retrospective study. We used IC and functional residual capacity (FRC) and their ratios to total lung capacity (TLC) as measures of lung hyperinflation. We used bivariate correlations and backwards regression analysis to assess possible associations between FEV1, lung hyperinflation, and measures of disease severity including questionnaire based quality of life, pulmonary exacerbation frequency, and mortality. The respiratory component of the Cystic Fibrosis Questionnaire-Revised (CRQ-R-Respiratory) was used as a measure of quality of life. Results: Both FEV1 and IC were negatively correlated with pulmonary exacerbations over a 3 year period (p = 0.004, r 2 = 0.127; p < 0.001, r 2 = 0.307, respectively), while FRC/TLC correlated positively with exacerbations (p = 0.007). Backwards regression analysis showed that among pulmonary function variables, IC had the strongest relationship with exacerbations over 3 years. A lower CFQ-R-Respiratory score was associated with greater mortality (p = 0.005). However, no statistically significant relationships were found between lung function and mortality. Conclusions: FEV1 and lung hyperinflation-as measured by IC and FRC/TLC-are both associated with pulmonary exacerbation frequency. This suggests that chronic dynamic hyperinflation contributes significantly to disease severity in adult cystic fibrosis.

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The Inspiratory Capacity To Total Lung Capacity Ratio Is Associated With Survival In Patients With Chronic Obstructive Pulmonary Disease

Cited by 2 publications

References 0 publications

Utility Inspiratory Capacity by Simple Spirometry as an indirect Measure of Air Trapping

Utility Inspiratory Capacity by Simple Spirometry as an indirect Measure of Air Trapping

Lung Hyperinflation Is Associated with Pulmonary Exacerbations in Adults with Cystic Fibrosis

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