The Insidious Effects of Childhood Obesity on Orthopedic Injuries and Deformities

Tisano, Breann; Anigian, Kendall; Kantorek, Nyssa; Kenfack, Yves Jordan; Johnson, Megan; Brooks, Jaysson T.

doi:10.1016/j.ocl.2022.06.008

Cited by 4 publications

(5 citation statements)

References 101 publications

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“…Metabolic differences in OAs may contribute to a higher risk of lower extremity fracture. Studies have shown obesity to have a negative effect on attaining peak bone mass in adolescents due to the alteration of bone metabolism during this period of rapid skeletal growth [ 26 , 27 ]. Obesity has been demonstrated in animal and cellular models to promote low grade inflammation.…”

Section: Discussionmentioning

confidence: 99%

Obese adolescents have higher risk for severe lower extremity fractures after falling

et al. 2023

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Introduction Reports vary on the impact of obesity on the incidence of lower extremity fractures after a fall. We hypothesized that obese adolescents (OA) presenting after a fall have a higher risk of any and severe lower extremity fractures compared to non-OAs. Methods A national database was queried for adolescents (12–17 years old) after a fall. Primary outcome included lower extremity fracture. Adolescents with a body mass index (BMI) ≥ 30 (OA) were compared to adolescents with a BMI < 30 (non-OA). Results From 20,264 falls, 2523 (12.5%) included OAs. Compared to non-OAs, the rate of any lower extremity fracture was higher for OAs (51.5% vs. 30.7%, p < 0.001). This remained true for lower extremity fractures at all locations (all p < 0.05). After adjusting for sex and age, associated risk for any lower extremity fracture (OR 2.41, CI 2.22–2.63, p < 0.001) and severe lower extremity fracture (OR 1.31, CI 1.15–1.49, p < 0.001) was higher for OAs. This remained true in subset analyses of ground level falls (GLF) and falls from height (FFH) (all p < 0.05). Conclusions Obesity significantly impacts adolescents’ risk of all types of lower extremity fractures after FFH or GLF. Hence, providers should have heightened awareness for possible lower extremity fractures in OAs. Level of evidence IV.

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Section: Discussionmentioning

confidence: 99%

Obese adolescents have higher risk for severe lower extremity fractures after falling

et al. 2023

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“…Childhood obesity poses a substantial risk for the development of adult obesity and several severe medical conditions, such as type 2 diabetes, cardiovascular disease, and metabolic dysfunction-associated fatty liver disease (MAFLD) [4][5][6]. Furthermore, childhood obesity has been linked to the emergence of various non-metabolic health issues, such as certain types of cancers, obstructive sleep apnea, asthma, infertility, polycystic ovary syndrome, orthopedic complications, and psychiatric disorders [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

The Reduced Gut Lachnospira Species Is Linked to Liver Enzyme Elevation and Insulin Resistance in Pediatric Fatty Liver Disease

Tsai,

Chiu,

Kek

et al. 2024

IJMS

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The objective of this study was to investigate gut dysbiosis and its metabolic and inflammatory implications in pediatric metabolic dysfunction-associated fatty liver disease (MAFLD). This study included 105 children and utilized anthropometric measurements, blood tests, the Ultrasound Fatty Liver Index, and fecal DNA sequencing to assess the relationship between gut microbiota and pediatric MAFLD. Notable decreases in Lachnospira spp., Faecalibacterium spp., Oscillospira spp., and Akkermansia spp. were found in the MAFLD group. Lachnospira spp. was particularly reduced in children with MAFLD and hepatitis compared to controls. Both MAFLD groups showed a reduction in flavone and flavonol biosynthesis sequences. Lachnospira spp. correlated positively with flavone and flavonol biosynthesis and negatively with insulin levels and insulin resistance. Body weight, body mass index (BMI), and total cholesterol levels were inversely correlated with flavone and flavonol biosynthesis. Reduced Lachnospira spp. in children with MAFLD may exacerbate insulin resistance and inflammation through reduced flavone and flavonol biosynthesis, offering potential therapeutic targets.

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“…La obesidad es una enfermedad compleja, recidivante y de origen multifactorial, que se caracteriza por una acumulación excesiva de grasa corporal, dada por un desequilibrio energético, que puede ser perjudicial para la salud debido a que se asocia con el desarrollo de enfermedades crónico-degenerativas, sobrecarga mecánica, daño cardiovascular, alteraciones metabólicas y psicosociales. [1][2][3][4][5] Cuando se trata con niños y adolescentes que viven con obesidad, es importante tener claro que la actividad física puede ciertamente asociarse con gasto de energía; sin embargo, no es menos relevante su trascendencia en el desarrollo somático, motriz, social, emocional e intelectual. 6,7 La actividad física es cualquier movimiento o actividad generado por la contracción de los músculos esqueléticos que aumenta el gasto de energía por sobre la tasa metabólica en reposo.…”

Section: Introductionunclassified

“…Del mismo modo, los niños y adolescentes que viven con obesidad pueden presentar alteraciones musculoesqueléticas, ortopédicas y biomecánicas, tales como alteraciones posturales, fatiga muscular y dolor articular. 4,9 Los factores señalados pueden, a su vez, afectar el interés o el nivel de confianza del niño de participar en juegos activos, lo que puede conducir a niveles más bajos de actividad física. Por lo tanto, es importante detectar las diferentes barreras físicas al movimiento para manejarlas adecuadamente una vez que han sido identificadas.…”

Section: Introductionunclassified

Recomendaciones de actividad física y reducción de conductas sedentarias para el manejo de la obesidad infantil

Pedraza-Escudero,

Garibay-Nieto,

Fuentes-Corona

et al. 2023

Revista Mexicana De Pediatría

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The Insidious Effects of Childhood Obesity on Orthopedic Injuries and Deformities

Cited by 4 publications

References 101 publications

Obese adolescents have higher risk for severe lower extremity fractures after falling

Obese adolescents have higher risk for severe lower extremity fractures after falling

The Reduced Gut Lachnospira Species Is Linked to Liver Enzyme Elevation and Insulin Resistance in Pediatric Fatty Liver Disease

Recomendaciones de actividad física y reducción de conductas sedentarias para el manejo de la obesidad infantil

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