The inorganic pyrophosphatases of microorganisms: a structural and functional review
Rodolfo García-Contreras,
Javier de la Mora,
Héctor Manuel Mora-Montes
et al.
Abstract:Pyrophosphatases (PPases) are enzymes that catalyze the hydrolysis of pyrophosphate (PPi), a byproduct of the synthesis and degradation of diverse biomolecules. The accumulation of PPi in the cell can result in cell death. Although the substrate is the same, there are variations in the catalysis and features of these enzymes. Two enzyme forms have been identified in bacteria: cytoplasmic or soluble pyrophosphatases and membrane-bound pyrophosphatases, which play major roles in cell bioenergetics. In eukaryotic… Show more
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