Abstract:The Innovative Medicines Initiative (IMI) is a large-scale public–private partnership between the European Commission and the European Federation of Pharmaceutical Industries and Associations (EFPIA). IMI aims to boost the development of new medicines across Europe by implementing new collaborative endeavours between large pharmaceutical companies and other key actors in the health-care ecosystem, i.e., academic institutions, small and medium enterprises, patients, and regulatory authorities. Currently there a… Show more
“…Public-private partnerships are alliances in which public and private entities work together and share resources and results to achieve mutually agreed objectives, which would have been out of range for each individual partner. Public-private partnerships are the most prominent example of multistakeholder collaborations that bring together the critical means from academia, governments, authorities, the pharmaceutical industry and patient organisations to drive the process of health innovation (Goldman, Compton and Mittleman, 2013;Vaudano, 2013). Their ultimate goal is to produce the maximum possible value, greater than the sum of what each partner alone could accomplish without collaboration.…”
Section: General Aspects Of Public-private Partnerships For Product Dmentioning
confidence: 99%
“…The pharmaceutical industry has been facing challenges of low drug development productivity, dwindling product pipelines and ever-increasing costs to deliver innovative treatments (Sternitzke, 2007;Vaudano, 2013;Woodstock, 2013). Not least because of the costs of up to USD 5.7 billion to develop an effective (disease-modifying) drug for Alzheimer's disease (Scott, 2014), the pharmaceutical industry has been cautious about large investments.…”
Section: The Position Of the Pharmaceutical Industrymentioning
(www.oecd.org/sti) develops evidence-based policy advice on the contribution of science, technology and industry to wellbeing and economic growth. STI Policy Papers cover a broad range of topics, including industry and globalisation, innovation and entrepreneurship, scientific R&D and emerging technologies. These reports are officially declassified by an OECD Committee.
“…Public-private partnerships are alliances in which public and private entities work together and share resources and results to achieve mutually agreed objectives, which would have been out of range for each individual partner. Public-private partnerships are the most prominent example of multistakeholder collaborations that bring together the critical means from academia, governments, authorities, the pharmaceutical industry and patient organisations to drive the process of health innovation (Goldman, Compton and Mittleman, 2013;Vaudano, 2013). Their ultimate goal is to produce the maximum possible value, greater than the sum of what each partner alone could accomplish without collaboration.…”
Section: General Aspects Of Public-private Partnerships For Product Dmentioning
confidence: 99%
“…The pharmaceutical industry has been facing challenges of low drug development productivity, dwindling product pipelines and ever-increasing costs to deliver innovative treatments (Sternitzke, 2007;Vaudano, 2013;Woodstock, 2013). Not least because of the costs of up to USD 5.7 billion to develop an effective (disease-modifying) drug for Alzheimer's disease (Scott, 2014), the pharmaceutical industry has been cautious about large investments.…”
Section: The Position Of the Pharmaceutical Industrymentioning
(www.oecd.org/sti) develops evidence-based policy advice on the contribution of science, technology and industry to wellbeing and economic growth. STI Policy Papers cover a broad range of topics, including industry and globalisation, innovation and entrepreneurship, scientific R&D and emerging technologies. These reports are officially declassified by an OECD Committee.
“…Such precompetitive consortia have sometimes been driven by government initiatives, such as with Europe's Innovative Medicines Initiative, which was founded in 2008 by the European Commission and the European Federation of Pharmaceutical Industries and Associations (Vaudano, 2013). Their effect has partly been to whet the appetite for greater collaboration, and there is an emerging new trend of precompetitive consortia that share information and knowledge-much of which was previously held proprietary-in the public domain.…”
Section: Precompetitive Consortia: the Road Aheadmentioning
“…Currently there are several small molecular inhibitors in clinical practice. Table 4 summarizes the current small molecular inhibitors in clinical practice [92–96,130,131] .…”
Section: Targeted Therapies and Current Drugsmentioning
Personalized medicine is the cornerstone of medical practice. It tailors treatments for specific conditions of an affected individual. The borders of personalized medicine are defined by limitations in technology and our understanding of biology, physiology and pathology of various conditions. Current advances in technology have provided physicians with the tools to investigate the molecular makeup of the disease. Translating these molecular make-ups to actionable targets has led to the development of small molecular inhibitors. Also, detailed understanding of genetic makeup has allowed us to develop prognostic markers, better known as companion diagnostics. Current attempts in the development of drug delivery systems offer the opportunity of delivering specific inhibitors to affected cells in an attempt to reduce the unwanted side effects of drugs.
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