The “Inner–Outer” Molecules-Loaded Fiber-Hydrogel Scaffolds Coordinate Specific Immunity and Neural Differentiation for Repairing SCI
Wei Hu,
Junchao Luo,
Chichi Chen
et al.
Abstract:The treatment of spinal cord injury (SCI) remains unsatisfactory because of the inflammatory microenvironment and the limited potential for nerve regeneration. However, most treatments have focused on modulating nonspecific immunity and ignored the importance of specific immunity in SCI. In this study, an "Inner− Outer" Metformin (Met) and anti-CD80 monoclonal antibody (CD80 mAb)-loaded fiber-hydrogel scaffold (P/G-Met-CD80 mAb) was constructed through microsol-electrospinning and UV illumination methods. The … Show more
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