The innate pathogen recognition molecule ficolin-1 exhibit differential binding to leukocyte subsets, providing a novel link between innate and adaptive immunity

Genster, Ninette; Ma, Yan-Hui; Munthe-Fog, Lea; Garred, Peter

doi:10.1016/j.molimm.2013.05.058

Cited by 2 publications

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“…The variant rs2989734 is located in the 3 0 untranslated region of the ficolin 1 (FCN1) gene. This gene codes for a protein (Ficolin1), which has an elastin-binding activity and which could also be involved in immune modulation in addition to its pathogen recognition function [23]. The analysis of proteomic data obtained from the cohort of 877 TCGA (The Cancer Genome Atlas) patients showed that high expression of the FCN1 protein was associated with decreased overall survival in kidney cancer [24], but this result has not yet been validated by a dedicated study.…”

Section: Discussionmentioning

confidence: 99%

Genetic variability in 13q33 and 9q34 is linked to aggressiveness patterns and a higher risk of progression of non‐muscle‐invasive bladder cancer at the time of diagnosis

et al. 2020

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Objective To identify single nucleotide polymorphisms (SNPs) associated with patterns of aggressiveness of non‐muscle‐invasive bladder cancer (NMIBC). Patients and Methods From January 2011 to December 2018, 476 patients with NMIBC were prospectively included. The first step aimed to identify SNPs associated with aggressiveness patterns (e.g. ≥pT1or high‐grade/Grade 3 or presence of carcinoma in situ) by analysing the data of a genome‐wide association study (GWAS) on 165 patients with BC. The second step aimed to validate the SNPs previously identified, by genotyping the germline DNA of 311 patients with NMIBC. Results Overall, the median (interquartile range) age was 66 (58–75) years and the rate of patients with aggressive NMIBC was comparable between both groups (46% vs 46%, P = 1). GWAS data analysis identified four SNPs associated with an aggressive NMIBC (rs12615669, rs4976845, rs2989734, and rs2802288). In the validation cohort, the genotype CC of rs12615669, as well as age >70 years at the time of diagnosis were associated with aggressive NMIBC (P = 0.008 and P < 0.001, respectively). Genotyping of the entire cohort showed an association between aggressive NMIBC and the T allele of rs12615669 (P = 0.0007), the A allele of rs4976845 (P = 0.012), and the A allele of rs2989734 (P = 0.007). A significant association was also found for the entire cohort between the risk of progression and the A allele of rs4976845 (P = 0.04). Conclusion This two‐phase study identified three SNPs (rs12615669, rs4976845, and rs2989734) associated with aggressive NMIBC and one SNP (rs4976845) associated with a higher risk of progression.

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Section: Discussionmentioning

confidence: 99%

Genetic variability in 13q33 and 9q34 is linked to aggressiveness patterns and a higher risk of progression of non‐muscle‐invasive bladder cancer at the time of diagnosis

et al. 2020

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Role of Liver X Receptor in Mastitis Therapy and Regulation of Milk Fat Synthesis

Zhang

2018

J Mammary Gland Biol Neoplasia

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Mastitis is important disease that causes huge economic losses in the dairy industry. In recent years, antibiotic therapy has become the primary treatment for mastitis, however, due to drug residue in milk and food safety factors, we lack safe and effective drugs for treating mastitis. Therefore, new targets and drugs are urgently needed to control mastitis. LXRα, one of the main members of the nuclear receptor superfamily, is reported to play important roles in metabolism, infection and immunity. Activation of LXRα could inhibit LPS-induced mastitis. Furthermore, LXRα is reported to enhance milk fat production, thus, LXRα may serve as a new target for mastitis therapy and regulation of milk fat synthesis. This review summarizes the effects of LXRα in regulating milk fat synthesis and treatment of mastitis and highlights the potential agonists involved in both issues.

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The innate pathogen recognition molecule ficolin-1 exhibit differential binding to leukocyte subsets, providing a novel link between innate and adaptive immunity

Cited by 2 publications

References 0 publications

Genetic variability in 13q33 and 9q34 is linked to aggressiveness patterns and a higher risk of progression of non‐muscle‐invasive bladder cancer at the time of diagnosis

Genetic variability in 13q33 and 9q34 is linked to aggressiveness patterns and a higher risk of progression of non‐muscle‐invasive bladder cancer at the time of diagnosis

Role of Liver X Receptor in Mastitis Therapy and Regulation of Milk Fat Synthesis

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