The Innate and Adaptive Immune Response to Pulmonary Histoplasma capsulatum Infection

Host Immune Responses Against Pulmonary Fungal Pathogens

“…H. capsulatum can initially be engulfed by macrophages, DCs, and neutrophils (reviewed in (Deepe, 2005)), however, H. capsulatum recognition by different receptors results in different fates (Gomez et al, 2008). DCs recognize H. capsulatum by VLA-5, by interaction with an unknown receptor, which results in uptake, killing, and antigen presentation (Gildea et al, 2001;Gomez et al, 2008).…”

“…Neutrophil phagocytosis of H. capsulatum requires opsonization with either antibody or complement (Brummer et al, 1991;Kurita et al, 1991a;Kurita et al, 1991b;Newman et al, 1993). Neutrophil uptake of H. capsulatum is fungistatic, as opposed to macrophages (permissive growth & replication) and DCs (fungicidal) (reviewed in Deepe, 2005). A lack of neutrophils causes a non-lethal infection to become a lethal infection (Zhou et al, 1998).…”