The injection of the blood vascular system of the uterus

Rossman, Isadore; Bartelmez, G. W.

doi:10.1002/ar.1091280207

Cited by 17 publications

(11 citation statements)

References 8 publications

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“…high blood flow impedance of the uterine radial arteries (Miwa et al, 2009). Early studies demonstrated that, after ovulation, the spiral arteries constrict preemptively to diminish blood flow to the functional layer (Rossman and Bartelmez, 1957). Nevertheless, a thinned or absent functional layer may subject the embryo to higher vascularity from the basal endometrium, which might explain the reduction of implantation caused by elevated oxygen tension and the production of detrimental reactive oxygen species (Catt and Henman, 2000;Yang et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Should we continue to measure endometrial thickness in modern-day medicine? The effect on live birth rates and birth weight

Ribeiro¹,

Santos‐Ribeiro

Munck

et al. 2018

Reproductive BioMedicine Online

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The evaluation of endometrial thickness (EMT) is still part of standard cycle monitoring during IVF, despite the lack of robust evidence of any value of this measurement to predict little revalidation in contemporary medical practice; other tools, however, such as endocrine profile monitoring, have become increasingly popular. The aim of this study was to reassess whether EMT affects the outcome of a fresh embryo transfer in modern-day medicine, using a retrospective, single-centre cohort of 3350 IVF cycles (2827 women) carried out between 2010 and 2014. In the multivariate regression analysis, EMT was non-linearly associated with live birth, with live birth rates being the lowest with an EMT less than 7.0 mm (21.6%; P < 0.001) and then between 7.0 mm and 9.0 mm (30.2%; P = 0.008). An EMT less than 7.0 mm was also associated with a decrease in neonatal birthweight z-scores (-0.40; 95% CI -0.69 to -0.12). In conclusion, these results reaffirm the use of EMT as a potential prognostic tool for live birth rates and neonatal birthweight in contemporary IVF, namely when considered together with other ovarian stimulation monitoring methods, such as the late-follicular endocrine profile.

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Section: Discussionmentioning

confidence: 99%

Should we continue to measure endometrial thickness in modern-day medicine? The effect on live birth rates and birth weight

Ribeiro¹,

Santos‐Ribeiro

Munck

et al. 2018

Reproductive BioMedicine Online

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“…The basal layer consists of large spiral arteries and is maintained throughout the menstrual cycle, whereas the functional layer includes relatively fine spiral arteries and changes throughout the menstrual cycle. After ovulation, the spiral arteries within the functional layer shrink, causing oxygen tension to decrease in the functional layer, which supports a favorable environment for embryo implantation [8]. If the functional layer is inadequately developed, embryos are close to the large spiral arteries within the basal layer; thus, embryos are exposed to a highly oxygenated environment.…”

Section: Discussionmentioning

confidence: 99%

The efficacy of intrauterine instillation of granulocyte colony-stimulating factor in infertile women with a thin endometrium: A pilot study

Lee

Jo²,

Kim

et al. 2016

Clin Exp Reprod Med

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ObjectiveThe study aimed to investigate the efficacy of intrauterine instillation of granulocyte colony-stimulating factor (G-CSF) on the day of ovulation triggering or oocyte retrieval in infertile women with a thin endometrium.MethodsFifty women whose endometrial thickness (EMT) was ≤8 mm at the time of triggering during at least one previous in vitro fertilization (IVF) cycle and an index IVF cycle were selected. On the day of triggering (n=12) or oocyte retrieval (n=38), 300 µg of G-CSF was instilled into the uterine cavity.ResultsIn the 50 index IVF cycles, the mean EMT was 7.2±0.6 mm on the triggering day and increased to 8.5±1.5 mm on the embryo transfer day (p<0.001). The overall clinical pregnancy rate was 22.0%, the implantation rate was 15.9%, and the ongoing pregnancy rate was 20%. The clinical pregnancy rate (41.7% vs. 15.8%), the implantation rate (26.7% vs. 11.7%), and the ongoing pregnancy rate (41.7% vs. 13.2%) were higher when G-CSF was instilled on the triggering day than when it was instilled on the retrieval day, although this tendency was likewise not statistically significant. Aspects of the stimulation process and mean changes in EMT were similar in women who became pregnant and women who did not.ConclusionIntrauterine instillation of G-CSF enhanced endometrial development and resulted in an acceptable pregnancy rate. Instillation of G-CSF on the triggering day showed better outcomes. G-CSF instillation should be considered as a strategy for inducing endometrial growth and good pregnancy results in infertile women with a thin endometrium.

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“…1) published by Bartelmez in 1957 (15), the functional layer of the endometrium has a vascular capillary structure, in contrast to the larger spiral arteries in the basal layer. Other early studies demonstrated constriction of the spiral arteries after ovulation, with diminished blood flow to the surface endometrium (16). One would presume that blood flow and, therefore, oxygen tension would be reduced in the functional or surface epithelium after ovulation and around the time of implantation.…”

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confidence: 97%