1991
DOI: 10.1016/0923-2508(91)90025-6
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The initiator titration model: computer simulation of chromosome and minichromosome control

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Cited by 161 publications
(192 citation statements)
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“…The currently most accepted model considers that DnaA, the protein which binds the origin of replication oriC to promote the assembly of the replication complex, constitutes the initiator protein in E. coli and several authors have argued that a threshold concentration of DnaA has to be reached for initiation to take place (Lobner-Olesen et al, 1989;Hansen et al, 1991). However, several observations are difficult to reconcile with DnaA as the sole master regulator (see Bremer and Churchward, 1991).…”
Section: Introductionmentioning
confidence: 97%
“…The currently most accepted model considers that DnaA, the protein which binds the origin of replication oriC to promote the assembly of the replication complex, constitutes the initiator protein in E. coli and several authors have argued that a threshold concentration of DnaA has to be reached for initiation to take place (Lobner-Olesen et al, 1989;Hansen et al, 1991). However, several observations are difficult to reconcile with DnaA as the sole master regulator (see Bremer and Churchward, 1991).…”
Section: Introductionmentioning
confidence: 97%
“…Alterations in DnaA concentration result in a variation of the time of initiation in the cell cycle (Loebner-Olesen et al, 1989). Models for initiation control postulate that DnaA accumulates to a critical level at which initiation occurs (Hansen et al, 1991). This implies that DnaA is itself intricately controlled, as will be discussed below.…”
Section: Introductionmentioning
confidence: 99%
“…DnaA is thought to have a central role in controlling initiation timing as alterations in its concentration lead to changes in the initiation mass (LerbnerOlesen et al, 1989); also, certain dnaA mutations cause loss of initiation synchrony (Boye et a/., 1988). Models for the control of initiation postulate that DnaA, or an initiation-competent form of DnaA, must accumulate to a critical level to permit initiation; immediate re-initiation is thought to be prevented by the post-initiation sequestration of origins and the dnaA promoter (Campbell and Kleckner, 1990), or through sequestration or inactivation of DnaA protein (Hansen et a/., 1991 ;Katayama, 1994).…”
Section: Introductionmentioning
confidence: 99%