The inhibitory role of synthesized Nickel oxide nanoparticles against Hep-G2, MCF-7, and HT-29 cell lines: the inhibitory role of NiO NPs against Hep-G2, MCF-7, and HT-29 cell lines

Abstract

Nickel oxide nanoparticles (NiO NPs) were synthesized via the facile sol-gel method. The synthesized NiO NPs were characterized using X-ray diffraction (XRD), Field-Emission Scanning Electron Microscopy (FESEM), Transmission Electron Microscopy (TEM), Raman and Fourier Transform Infrared (FT-IR) techniques. The effect of particle size was analyzed on structural alterations, electrochemical behaviors, and cytotoxic effect of synthesized NiO NPs. According to TEM results, the particle sizes of synthesized NiO NPs were 8.2, 15.4, and 21.7 nm at 300, 400, and 500°C, respectively. Electrochemical behaviors of synthesized NiO NPs were assessed through the cyclic voltammetry (CV) technique. The results showed that the magnitude of the current density was decreased in treated samples exposed to higher temperature values. The cytotoxic activity of synthesized nanoparticles was investigated against human liver cancer cell (Hep-G2), breast cancer cell (MCF-7), and colon cancer cell (HT-29) lines using the MTT assay. The results demonstrated that synthesized NiO NPs had higher cytotoxicity at 300˚C than at 400 and 500˚C, because of their small particle size. Thus, synthesized NiO NPs exhibit acceptable cytotoxic effects against Hep-G2, MCF-7, and HT-29 cancer cell lines so that they could be a good choice for cancer treatment.

Modulating Electron Density of Boron–Oxygen Groups in Borate via Metal Electronegativity for Propane Oxidative Dehydrogenation

“…In catalyst NiBOx-1000, B atoms formed planar BO 3 structures with three oxygen atoms, while Ni atoms formed octahedral structures with six O atoms within the crystal lattice of Ni 3 (BO 3 ) 2 ( Figure 2 b and Figure S7 ). These observations were validated by FTIR spectra, which exhibited prominent Ni-O vibrations [ 23 ] between 600–723 cm −1 and BO 3 bond vibrations between 1200–1500 cm −1 [ 14 , 24 ], and a distinct peak at 723 cm −1 corresponded to -OH vibrations ( Figure 2 e, red). The structural diagram of AlBOx-1000 revealed two distinct forms of Al atoms: one formed an octahedral structure with six oxygen atoms, while the other exhibited five-coordinated structures with five oxygen atoms ( Figure 2 c and Figure S8 ).…”

Synthesis of NiO nanoparticles from Paulownia tomentosa plant extracts via a green synthesis method and antibacterial, antibiofilm and cytotoxicity applications

“…In another study of NiO NPs obtained from Calotropis gigantea (a crown flower), it was reported that the NPs had significant anticancer effects on the liver cancer (HepG2) cell line 44 . In the study of NiO NPs obtained by a different method, it was stated that NiO NPs could be effective anticancer agents for three different cancer cell lines 46 …”

“…44 In the study of NiO NPs obtained by a different method, it was stated that NiO NPs could be effective anticancer agents for three different cancer cell lines. 46…”

Lanthanide-Doped ZnO Nanoparticles: Unraveling Their Role in Cytotoxicity, Antioxidant Capacity, and Nanotoxicology

“…The cytotoxicity of Z, ZL, ZS, and ZLS was evaluated against two cell lines: MCF-7 and HT29 (see Figure 7). The former is a representative cellular model used to explore the potential use of nanostructures against breast cancer [39], which is the most common cancer diagnosed among women worldwide, and the fifth most common cause of cancer-related deaths in the last few years [40]. Similarly, the latter is utilized to investigate the possible use of nanomaterials to develop therapies against colorectal cancer [41], which is a complex type of cancer that has remained as the third most common type of cancer diagnosed for men and women worldwide and the third most common cause of cancer-related deaths in the United States of America (USA) [42].…”