The inhibitory effects of topical chelating agents and antioxidants on nickel-induced hypersensitivity reactions

Memon, Aamir; Molokhia, Mohamed M.; Friedmann, Peter S.

doi:10.1016/s0190-9622(94)70062-1

Cited by 47 publications

(20 citation statements)

References 13 publications

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“…The apparently most effective chelating agent for this kind of application is clioquinol. 294 Due to a range of different toxic effects, this chelator is, however, unsuitable for general use in prevention of Ni dermatitis. 286 A cream with a cation-exchange resin had some protective effect.…”

Section: N Nickelmentioning

confidence: 99%

Principles and Recent Developments in Chelation Treatment of Metal Intoxication

1999

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Section: N Nickelmentioning

confidence: 99%

Principles and Recent Developments in Chelation Treatment of Metal Intoxication

1999

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“…Memon et al (4) showed that 15% EDTA reduced the allergenic nickel reaction in only 40% of the subjects, whereas Van Ketel & Bruynzeel (5) showed a higher success rate using 10% Na 2 H 2 EDTA. This difference may be due to .differences in patch testing methodology, the nature of the cream base or the form of EDTA.…”

Section: Discussionmentioning

confidence: 99%

The prevention of nickel contact dermatitis

1995

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Chelating agents and other substances can be used to bind nickel or reduce its penetration through the skin, and hence to reduce the symptoms in subjects with nickel sensitivity. Topical usage is mostly described but, in some studies, chelating agents have been given systemically. The most effective ligand for nickel so far described is 5-chloro-7-iodoquinolin-8-ol. Although normally regarded as safe, its usage in some situations may be limited by concerns about its toxicity. Other ligands with demonstrable effect include ethylenediaminetetraacetic acid in various forms, diphenylglyoxime and dimethylglyoxime. Cation exchange resins can effectively bind nickel and work both in vitro and in vivo. Propylene glycol, petrolatum and lanolin reduce the absorption of nickel through the skin. Corticosteroids and cyclosporin work in nickel dermatitis by suppressing the immunological reaction rather than through an effect on nickel. Studies of the oral administration of ligands such as tetraethylthiuram disulphide have given conflicting results but the use of these agents is limited by hepatotoxicity in any case. Some compounds offer potential for use in the prophylaxis of nickel dermatitis. Further work is required to develop the existing agents and to look at the use of novel combinations, such as that of a cation exchanger with a ligand.

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“…21 Barrier creams act as an invisible glove, protecting the skin from environmental allergens. 22 The most utilized binding agent is ethylene diamine tetraacetic acid (ETDA), which can be included at a 15% concentration in a cream in association with topical steroids. 23 In our study, average number of drugs per prescription is 6.8 which was found to be higher compared to a previous study done by Narwane et al, which should be decreased as use of polypharmacy is associated with so many problems like more drug interactions, more adverse effects, decrease in patient compliance, increased incidence of drug resistance and finally increased economic burden on the patients.…”

Section: 13mentioning

confidence: 99%