The Inhibitory Effects of Phenolic and Terpenoid Compounds from Baccharis trimera in Siha Cells: Differences in Their Activity and Mechanism of Action

Oliveira, Cristiane Bernardes de; Comunello, Lucimara Nardi; Maciel, Érica Santos; Giubel, Scheron R; Bruno, Alessandra Nejar; Filippi-Chiela, Eduardo Cremonese; Lenz, Guido; Gnoatto, Simone Cristina Baggio; Buffon, Andréia; Gosmann, Grace

doi:10.3390/molecules180911022

Cited by 32 publications

(24 citation statements)

References 23 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Purification of phenolic compounds from natural sources to homogeneity is a challenging task (Anantharaju, Gowda, Vimalambike, & Madhunapantula, 2016). Therefore, several studies have tested the ability of either crude extracts rich in phenolic compounds or the fractions containing a mixture of phenolic compounds for inhibiting cancer cell proliferation in vitro and in vivo (de Oliveira et al, 2013;Ghasemzadeh & Jaafar, 2013).…”

Section: Discussionmentioning

confidence: 99%

Antiproliferative and cytotoxic effects of grape pomace and grape seed extracts on colorectal cancer cell lines

Pérez‐Ortiz

Alguacil

Salas

et al. 2019

Food Science & Nutrition

View full text Add to dashboard Cite

Grape pomace is the source of bioactive compounds (anthocyanins, flavonols, flavan‐3‐ols, and stilbenes) which exhibit antiproliferative actions on cell cultures. We have investigated the antitumoral effects of grape pomace and grape seed extracts on colon cancer cells (Caco‐2, HT‐29) and fibroblasts. Crude extracts prepared from white and red pomace, and grape seeds, reduced the viability and proliferation of Caco‐2. HT‐29 cells were resistant to these actions. Purified extracts were then prepared from the same sources and compared with the LDH test; again, all three extracts were active and purified extract from grape seed was the most potent and specific on Caco‐2 cells. HT‐29 cells were more sensitive to these purified extracts. The biological activity resided almost exclusively in the flavonol and flavan‐3‐ols subfractions, rather than the anthocyanin subfraction. Preliminary results on the mechanisms involved in these effects revealed downregulation of Myc gene expression in HT‐29 and upregulation of Ptg2 in Caco‐2 cells.

show abstract

Section: Discussionmentioning

confidence: 99%

Antiproliferative and cytotoxic effects of grape pomace and grape seed extracts on colorectal cancer cell lines

Pérez‐Ortiz

Alguacil

Salas

et al. 2019

Food Science & Nutrition

View full text Add to dashboard Cite

show abstract

“…This results in the release of cellular components, including LDH enzyme into the surrounding environment. Therefore, measuring the levels of LDH in cell culture supernatant can help to distinguish between two types of cell death (Oliveira et al, 2013). Data of LDH release assay showed that IR-SF has significantly lower LDH levels as compared with Triton X100 (a known necrotic agent).…”

Section: Discussionmentioning

confidence: 99%

Isoledene from Mesua ferrea oleo-gum resin induces apoptosis in HCT 116 cells through ROS-mediated modulation of multiple proteins in the apoptotic pathways: A mechanistic study

et al. 2016

View full text Add to dashboard Cite

“…For example the extracts of Pandanus amaryllifolius (herbal plant from Malaysian region) containing gallic acid, cinnamic acid and ferulic acid are reported to inhibit breast cancer cell lines in vitro [35]. Similarly, the extracts of Baccharis trimera, containing gallic acid, pyrogallol, syringic acid and caffeic acid were shown to suppress the formation of tumor cell colonies and proliferation of SiHa cells in a dose dependent manner [36]. Likewise, Thanaset et al, 2014 have demonstrated the time- and dose dependent growth inhibitory effect of water soluble constituents of commercially available Houttuynia cordata fermentation products on HeLa, HCT116, and HT29 cells.…”

Section: Introductionmentioning

confidence: 99%

An overview on the role of dietary phenolics for the treatment of cancers

Anantharaju

Prathima

Vimalambike

et al. 2016

Nutr J

359

248

View full text Add to dashboard Cite

Plant derived phenolic compounds have been shown to inhibit the initiation and progression of cancers by modulating genes regulating key processes such as: (a) oncogenic transformation of normal cells; (b) growth and development of tumors; and (c) angiogenesis and metastasis. Recent studies focusing on identifying the molecular basis of plant phenolics-induced cancer cell death have demonstrated down-regulation of: (a) oncogenic survival kinases such as PI3K and Akt; (b) cell proliferation regulators that include Erk1/2, D-type Cyclins, and Cyclin Dependent Kinases (CDKs); (c) transcription factors such as NF-kβ, NRF2 and STATs; (d) histone deacetylases HDAC1 and HDAC2; and (e) angiogenic factors VEGF, FGFR1 and MIC-1. Furthermore, while inhibiting oncogenic proteins, the phenolic compounds elevate the expression of tumor suppressor proteins p53, PTEN, p21, and p27. In addition, plant phenolic compounds and the herbal extracts rich in phenolic compounds modulate the levels of reactive oxygen species (ROS) in cells thereby regulate cell proliferation, survival and apoptosis. Furthermore, recent studies have demonstrated that phenolic compounds undergo transformation in gut microbiota thereby acquire additional properties that promote their biological activities. In vitro observations, preclinical and epidemiological studies have shown the involvement of plant phenolic acids in retarding the cancer growth. However, to date, there is no clinical trial as such testing the role of plant phenolic compounds for inhibiting tumor growth in humans. More over, several variations in response to phenolic acid rich diets-mediated treatment among individuals have also been reported, raising concerns about whether phenolic acids could be used for treating cancers. Therefore, we have made an attempt to (a) address the key structural features of phenolic acids required for exhibiting potent anti-cancer activity; (b) review the reported findings about the mechanisms of action of phenolic compounds and their transformation by gut microbiota; and (c) update the toxicological aspects and anti-tumor properties of phenolic compounds and extracts containing phenolic compounds in animals.

show abstract

The Inhibitory Effects of Phenolic and Terpenoid Compounds from Baccharis trimera in Siha Cells: Differences in Their Activity and Mechanism of Action

Cited by 32 publications

References 23 publications

Antiproliferative and cytotoxic effects of grape pomace and grape seed extracts on colorectal cancer cell lines

Antiproliferative and cytotoxic effects of grape pomace and grape seed extracts on colorectal cancer cell lines

Isoledene from Mesua ferrea oleo-gum resin induces apoptosis in HCT 116 cells through ROS-mediated modulation of multiple proteins in the apoptotic pathways: A mechanistic study

An overview on the role of dietary phenolics for the treatment of cancers

Contact Info

Product

Resources

About