The Inhibitory Effects of Local Anesthetics on Superoxide Generation of Neutrophils Correlate with Their Partition Coefficients

The use of lidocaine as an anti-inflammatory substance: A systematic review

“…6 It was demonstrated that LAs inhibit neutrophil adhesion, migration and accumulation, 7 macrophage activity, and enzyme liberation. 8 Additionally, there is a reduction in vascular permeability inhibiting edema after intravenous and systemic administration of lidocaine and bupivacaine. 2 Due to the extensive use of lidocaine as a local anesthetic in dentistry, it was natural to assume that the anti-inflammatory potential of LAs would be used in operative and preventive dentistry, especially in the reduction of periodontal inflammation, 9 or as auxiliary in the treatment of surgical and traumatic lesions.…”

Comparative evaluation of in vitro and in vivo high glucose-induced alterations in voltage-gated tetrodotoxin-resistant sodium channel: Effects attenuated by sodium channel blockers

“…Moreover, a recent report suggested that lidocaine induced gene expression and apoptosis by modulating the above intracellular signalling molecules (Villarruel et al, 2011). Tetracaine and mepivacaine have shown inhibition of phosphoinositol hydrolysis which further limits the PKC activation (Hattori et al, 1997).…”

Neutrophil effector functions triggered by Fc-gamma and/or complement receptors are dependent on B-ring hydroxylation pattern and physicochemical properties of flavonols

“…Moreover, a non-specific effect of steroids, of nonsteroidal anti-inflammatory drugs, pentoxifiline, local anesthetics and some flavonoids upon membrane fluidity have been reported to be part of the mechanisms whereby these agents influence PMNs functions, such as phagocytosis and chemotaxis (Lamche et al, 1990;Abramsom et al, 1990;Buescher et al, 1990;Tauber, 1984;Hattori et al, 1997).…”