The inhibitory effects of gentian violet on STAT6 signaling shed light on its classic yet modern therapeutic use for prurigo nodularis

Fukushi, Sawako; Ito, Yumiko; Kimura, Yutaka; Aiba, Setsuya

doi:10.1016/j.jdermsci.2012.11.401

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Dermatitis and Other Uses In Dermatology1

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2013

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“…There have also been published case reports of GV treating the skin lesions of transgrediens pachyonychia congenita and hypereosinophillic syndrome . A recent study showed that topical administration of GV may be effective in treating purigo nodularis and atopic dermatitis, and further study is needed . We have found that atopic dermatitis expresses high levels of ang‐2, accounting for the vascular permeability and erythema observed in atopic dermatitis .…”

Section: Dermatitis and Other Uses In Dermatologymentioning

confidence: 74%

Gentian Violet: a 19th century drug re‐emerges in the 21st century

Maley

Arbiser

2013

Experimental Dermatology

125

108

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Gentian violet (GV) has a long and varied history as a medicinal agent. Historically used as an anti-bacterial and anti-fungal, recent reports have shown its utility as an anti-typranosomal, anti-viral and anti-angiogenic agent. The objective of this paper is to summarize evidence regarding the efficacy, and safety of GV use in dermatology. Recent discoveries have found novel targets of GV, namely NADPH oxidase in mammalian cells and thioredoxin reductase 2 in bacterial, fungal, and parasitic cells. These discoveries have expanded the use of GV in the 21st century. Given that GV is well tolerated, effective and inexpensive, its use in dermatology is predicted to increase.

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Section: Dermatitis and Other Uses In Dermatologymentioning

confidence: 74%