The inhibitory effects of Gelam honey and its extracts on nitric oxide and prostaglandin E2 in inflammatory tissues

Kassim, Mustafa; Achoui, Mouna; Mansor, Marzida; Yusoff, Kamaruddin Mohd

doi:10.1016/j.fitote.2010.07.024

Cited by 115 publications

(102 citation statements)

References 24 publications

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“…However, this reduction only was significant in the honey group compared to the AA-colitis group. Honey and its extracts significantly decreased edema perhaps through the suppression of NO and PGE2 production as molecular vasodilators (28). Previous studies have not reported the effects of preadministration of honey alone and honey + SP on colon weight/length ratio.…”

Section: Discussionmentioning

confidence: 96%

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Protective Effects of Honey and Spirulina Platensis on Acetic Acid-Induced Ulcerative Colitis in Rats

Rezaei

Eftekhari

Tanideh

et al. 2018

Iran Red Crescent Med J

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Background: Overproduction of reactive oxygen species (ROS) causes increased lipid peroxidation, decreased intestinal epithelial barrier integrity, and ultimately mucosal disruption and ulceration. Several studies have confirmed the antioxidant, antiinflammatory, and immunomodulatory properties of Spirulina Platensis (SP), edible blue -green algae, in various inflammatory diseases. In addition, natural honey, a source of phenolic and flavonoid compounds, is a powerful antioxidant, which can help prevent chronic oxidative stress and subsequent inflammation. Objectives: In this study, we examined and compared the protective effects of SP and honey on ulcerative colitis induced by acetic acid (AA) in rats. Methods: Forty male rats were allocated into five groups (N = 8) and received pretreatment for 32 consecutive days. The administrations were as follows: group 1 (control) and group 2 (AA-colitis group): normal saline, group 3: 1 ml honey/day, group 4: 1 ml honey/day plus 1 g/kg SP, and group 5: 1 g/kg SP. Colitis was induced on the 30th day in groups 2 to 5. On day 32, the clinical activity was determined and anesthetized animals were sacrificed. Serum interleukin-6 (IL-6), IL-1β, tumor necrosis factor-α (TNF-α), glutathione peroxidase (GPx), reduced glutathione (GSH), total antioxidant capacity (TAC), superoxide dismutase (SOD), colonic tissues myeloperoxidase (MPO), prostaglandin E2 (PGE2), malondialdehyde (MDA), nitric oxide (NO), and colonic weight/length ratio were determined. In addition, histopathological changes of the colon were observed microscopically.

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Section: Discussionmentioning

confidence: 96%

“…For instance, polyphenols (e.g. caffeic acid, ellagic acid, chrysin, and quercetin) by down -regulation of NF-κB decreased the biosynthesis of iNOS and inhibited NO production (28,35). Gallic acid, a phenolic compound in honey, can decline lipid peroxidation by free radical scavenging (36).…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Honey and Spirulina Platensis on Acetic Acid-Induced Ulcerative Colitis in Rats

Rezaei

Eftekhari

Tanideh

et al. 2018

Iran Red Crescent Med J

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“…The first phase (1 h) involves the release of serotonin and histamine and the second phase (> 1 h) is mediated by cyclooxygenase products and the continuity between the two phases is provided by kinins [15,16]. Prostaglandins (PG) (PGE2) play an essential role in inflammation [17].…”

Section: Discussionmentioning

confidence: 99%

Preliminary comparative study of anti-inflammatory effect of unheated and heat-treated Sahara honey: In vivo approach

2015

J Coast Life Med

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“…The honey was certified to be pure after it was analyzed at the Department of Molecular Medicine of the Faculty of Medicine, University of Malaya. Many studies have been conducted on this honey to show its superior qualities, having powerful antioxidant, antiinflammatory, and antibacterial activities (11)(12)(13)(14)(15).…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have been done to explain the various properties found in honey that contribute to their antioxidant, antiinflammatory, antibacterial, antiviral, antiulcerogenic, antihepatotoxic, antiallergic, and hypolipidemic properties (11)(12)(13)(14). Previous study (15) has shown that honey healed chronic wounds and ulcers that had failed to heal under conventional treatment.…”

Section: Introductionmentioning

confidence: 99%

Posttonsillectomy pain relief and epithelialization with honey

Letchumanan¹,

Rajagopalan²,

M.Y.Kamaruddin³

2013

Turk J Med Sci

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A new method was established for the simultaneous determination of Sn(II) and Sn(IV) using differential pulse polarography (DPP). Among several electrolytes, 0.1 M NaOH in the presence of 0.1 M KNO 3 was found to be the most suitable one. In this medium, Sn(II) had 2 peaks, at -0.74 and -1.17 V, which were sharp and very sensitive. Sn(IV), on the other hand, had a very small peak at -0.92 V when its concentration was higher than 4.0 × 10 −4 M. Thus, it was decided to determine Sn(IV) after reduction into Sn(II). In the presence of both Sn(II) and Sn(IV), Sn(II) was first determined from the peak at -1.17 V, and then Sn(IV) was determined after its reduction with NaBH 4 into Sn(II). The detection limit was 5.5 × 10 −7 M and 8.2 × 10 −7 M for Sn(II) and Sn(IV), respectively. The interference effect of the most common ions, Fe(III), Cu(II), Pb(II), Cd(II), and Zn(II), was investigated. Only copper and iron had an interfering effect during the speciation procedures, since they oxidized Sn(II), which was formed after reduction of Sn(IV) for its determination. This effect of Cu(II) and Fe(III) ions could be eliminated by the reducing agent NaBH 4 , which was used for the reduction of Sn(IV). Since Pb(II) and Cd(II) peaks overlap with the first peak of Sn(II) at -0.74V, Sn(II) was determined using the second peak, at -1.17 V. In a synthetic sample containing Sn(II), Sn(IV), and all common ions, the total content of tin (2.0 × 10 −5 M) was found to be (2.07 ± 0.38) × 10 −5 M (90% CI, N = 3). This method was applied for the determination of tin in canned tomato sauce.

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The inhibitory effects of Gelam honey and its extracts on nitric oxide and prostaglandin E2 in inflammatory tissues

Cited by 115 publications

References 24 publications

Protective Effects of Honey and Spirulina Platensis on Acetic Acid-Induced Ulcerative Colitis in Rats

Protective Effects of Honey and Spirulina Platensis on Acetic Acid-Induced Ulcerative Colitis in Rats

Preliminary comparative study of anti-inflammatory effect of unheated and heat-treated Sahara honey: In vivo approach

Posttonsillectomy pain relief and epithelialization with honey

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