The inhibitory effects of ethanol extracts from sorghum, foxtail millet and proso millet on α-glucosidase and α-amylase activities

Kim, Ju-Sung; Hyun, Tae Kyung; Kim, Myong Jo

doi:10.1016/j.foodchem.2010.08.020

Cited by 193 publications

(132 citation statements)

References 34 publications

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“…(37)(38)(39)(40)(41) These interactions inhibit carbohydrate-hydrolyzing enzymes, such as α-glucosidase and α-amylase, thereby lowering starch digestibility. (42) The presence of the protein matrix has also been associated with reduced starch gelatinization during cooking resulting in partially-gelatinized sorghum starch granules that may resist enzymatic degradation in vivo. (27) Sorghum starch has amongst the highest gelatinization temperatures, ranging from 66-81 °C, depending upon cultivars, and is higher than that of maize, wheat and barley.…”

Section: Starchesmentioning

confidence: 99%

Sorghum: An Underutilized Cereal Whole Grain with the Potential to Assist in the Prevention of Chronic Disease

Stefoska‐Needham

Beck

Johnson

et al. 2015

Food Reviews International

137

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Section: Starchesmentioning

confidence: 99%

Sorghum: An Underutilized Cereal Whole Grain with the Potential to Assist in the Prevention of Chronic Disease

Stefoska‐Needham

Beck

Johnson

et al. 2015

Food Reviews International

137

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“…stearothermophilus α-glucosidase inhibition assay was performed as described previously 15 . α-glucosidase (50 µl, 0.5 U/ml) and 0.2 M K 3 PO 4 buffer (pH 6.8, 50 µl) were mixed with 50 µl of the test sample.…”

Section: α-Glucosidase Inhibitory Effectmentioning

confidence: 99%

In vitro antioxidant and antidiabetic activities of Rehmannia glutinosa tuberous root extracts

Jeong¹,

Kim²,

Hyun³

et al. 2013

ScienceAsia

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To analyse the antioxidant and antidiabetic activities of Rehmannia glutinosa tuberous roots, extracts with nine different solvents were investigated.Antioxidant activity was measured with two methods, 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging and reducing power. Each extract exhibited a dose-dependent free radical scavenging action against DPPH and a reducing power, but diverse antioxidant activities. To determine the antidiabetic activity, we measured the α-glucosidase inhibitory capacity of each extract. We found that 10 µg/ml of 60% MeOH or 80% of MeOH extract inhibited more than 90% of α-glucosidase activity, and this inhibitory activity was not mediated by catalpol, a major iridoid constituent of R. glutinosa tuberous roots. Overall, the data suggested that the tuberous roots of R. glutinosa have potential as natural antioxidants and antidiabetics.

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“…Nutritional studies concerning the application of cereal grain diets rich in inhibitors of ␣ -amylases proved that their biological activity significantly influences the metabolism of starch of the studied organisms. The proteins consumed in food are resistant to digestion by pepsin and they are transported in their unchanged form to the duodenum, where they inactivate porcine pancreas amylase ( 16 ). Inhibitors of ␣ -amylases can play a significant function in diet therapy for metabolic syndrome, because they hinder absorption of saccharides into the alimentary tract, which lowers the glycemic index of consumable food ( 15 , 17 ).…”

mentioning

confidence: 99%

Digestive Enzyme Inhibitors from Grains as Potential Components of Nutraceuticals

Piasecka‐Kwiatkowska

Warchalewski

Zielińska‐Dawidziak

et al. 2012

J Nutr Sci Vitaminol

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Summary Inhibitor activity against digestive enzymes, such as ␣ -amylase from human saliva and porcine pancreas and trypsin from bovine pancreas, of three cereal grains species were studied as potential components of nutraceuticals strengthening diabetes and obesity treatment. Significant differences were demonstrated: the highest antitryptic activity was found in the grain of the rye varieties studied, whereas the grain of the wheat varieties had significantly higher ability to inhibit ␣ -amylases from human saliva and porcine pancreas. Additionally, seeds of Puma, one of the studied wheat varieties, demonstrated especially low antitryptic activity. Such a beneficial arrangement of inhibitors, i.e. high level of inhibitors of ␣ -amylase from human saliva and porcine pancreas and simultaneously low level of trypsin inhibitors from bovine pancreas, indicate the possibility of the application of seeds with such properties to the preparation of nutraceuticals for people with obesity or suffering from diabetes.

show abstract

The inhibitory effects of ethanol extracts from sorghum, foxtail millet and proso millet on α-glucosidase and α-amylase activities

Cited by 193 publications

References 34 publications

Sorghum: An Underutilized Cereal Whole Grain with the Potential to Assist in the Prevention of Chronic Disease

Sorghum: An Underutilized Cereal Whole Grain with the Potential to Assist in the Prevention of Chronic Disease

In vitro antioxidant and antidiabetic activities of Rehmannia glutinosa tuberous root extracts

Digestive Enzyme Inhibitors from Grains as Potential Components of Nutraceuticals

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