The Inhibitory Effects of Aqueous Extract of Magnolia officinalis on Human Mesangial Cell Proliferation by Regulation of Platelet-Derived Growth Factor-BB and Transforming Growth Factor-β1 Expression

Lee, Byung-Cheol; Doo, Ho-Kyung; Lee, Hee-Jae; Jin, Sheng‐Yu; Jung, Jong‐Hyun; Hong, Seung-Jae; Lee, Sang-Ho; Kim, Sung-Do; Park, Jae-Kyung; Leem, Kang‐Hyun; Ahn, Sung-Ho

doi:10.1254/jphs.94.81

Cited by 10 publications

(4 citation statements)

References 13 publications

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“…Additionally, other studies showed that honokiol inhibited angiogenesis by interfering with VEGFR2 autophosphorylation [14] and subsequently blocking the VEGF-induced Rac activation [28], which is required for endothelial cell migration and proliferation [29]. In addition, regulation of platelet-derived endothelial cell growth factor and TGF-b expression [30], inhibition of nitric oxide synthesis and TNF-a [31] might be involved in this event. Further studies will be conducted to elucidate the intensive mechanism of honokiol in angiogenesis.…”

Section: Discussionmentioning

confidence: 99%

Honokiol, a natural therapeutic candidate, induces apoptosis and inhibits angiogenesis of ovarian tumor cells

Liu

Zhao

et al. 2008

European Journal of Obstetrics & Gynecology and Reproductiv

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Section: Discussionmentioning

confidence: 99%

Honokiol, a natural therapeutic candidate, induces apoptosis and inhibits angiogenesis of ovarian tumor cells

Liu

Zhao

et al. 2008

European Journal of Obstetrics & Gynecology and Reproductiv

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“…It also inhibits nitric oxide synthesis and TNF-a expression. 108,109 In animal experiments, it suppresses the proliferation of blood vessel endothelial cells more than other types of cells and thereby reduces tumor growth. 110,111 Silybum marianum (Milk Thistle) Silibinin and silymarin are polyphenolic flavonoids isolated from the fruits or seeds of S. marianum (L.) Gaertn.…”

Section: Magnolia Officinalis (Chinese Magnolia Tree)mentioning

confidence: 99%

Section: Magnolia Officinalis (Chinese Magnolia Tree)mentioning

confidence: 99%

Targeting Angiogenesis With Integrative Cancer Therapies

2006

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An integrative approach for managing a patient with cancer should target the multiple biochemical and physiological pathways that support tumor development while minimizing normal tissue toxicity. Angiogenesis is a key process in the promotion of cancer. Many natural health products that inhibit angiogenesis also manifest other anticancer activities. The authors will focus on natural health products (NHPs) that have a high degree of antiangiogenic activity but also describe some of their many other interactions that can inhibit tumor progression and reduce the risk of metastasis. NHPs target various molecular pathways besides angiogenesis, including epidermal growth factor receptor (EGFR), the HER-2/neu gene, the cyclooxygenase-2 enzyme, the NF-kB transcription factor, the protein kinases, Bcl-2 protein, and coagulation pathways. The herbalist has access to hundreds of years of observational data on the anticancer activity of many herbs. Laboratory studies are confirming the knowledge that is already documented in traditional texts. The following herbs are traditionally used for anticancer treatment and are antiangiogenic through multiple interdependent processes that include effects on gene expression, signal processing, and enzyme activities: Artemisia annua (Chinese wormwood), Viscum album (European mistletoe), Curcuma longa (turmeric), Scutellaria baicalensis (Chinese skullcap), resveratrol and proanthocyanidin (grape seed extract), Magnolia officinalis (Chinese magnolia tree), Camellia sinensis (green tea), Ginkgo biloba, quercetin, Poria cocos, Zingiber officinale (ginger), Panax ginseng, Rabdosia rubescens (rabdosia), and Chinese destagnation herbs. Quality assurance of appropriate extracts is essential prior to embarking on clinical trials. More data are required on dose response, appropriate combinations, and potential toxicities. Given the multiple effects of these agents, their future use for cancer therapy probably lies in synergistic combinations. During active cancer therapy, they should generally be evaluated in combination with chemotherapy and radiation. In this role, they act as biological response modifiers and adaptogens, potentially enhancing the efficacy of the so-called conventional therapies. Their effectiveness may be increased when multiple agents are used in optimal combinations. New designs for trials to demonstrate activity in human subjects are required. Although controlled trials might be preferred, smaller studies with appropriate end points and surrogate markers for antiangiogenic response could help prioritize agents for the larger resource-intensive phase 3 trials.

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“…Nitrik oksit sentez ve tümör nekroz faktör alfa (TNF-a) ekspresyonunu da azaltmaktadır. [31,32] Silybum marianum (Milk thistle)…”

Section: Curcuma Longa (Kurkumin)unclassified

Natural health products that inhibit tumoral angiogenesis

Taşkıran¹,

Akar²,

Erbaş³

2017

FNG & Bilim Tıp Transplantasyon Dergisi

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Neovascularization is controlled by a sequence of endogenous polypeptides released during growth, healing and tissue renewal in normal tissues. Neoplasms have the ability to stimulate and synthesize and the most important ones are the vascular endothelial growth factor and angiopoetins. By using monoclonal antibodies, targeted therapies are recently developed, which block the formation of new blood vessels. Data we have until now show that the use of single agent antiangiogenesis has limited efficacy. Natural health products consist of complex organic chemicals and many substances with synergistic activity against cancer. In this review, we discuss natural health products that have antiangiogenic effect.

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The Inhibitory Effects of Aqueous Extract of Magnolia officinalis on Human Mesangial Cell Proliferation by Regulation of Platelet-Derived Growth Factor-BB and Transforming Growth Factor-β1 Expression

Cited by 10 publications

References 13 publications

Honokiol, a natural therapeutic candidate, induces apoptosis and inhibits angiogenesis of ovarian tumor cells

Honokiol, a natural therapeutic candidate, induces apoptosis and inhibits angiogenesis of ovarian tumor cells

Targeting Angiogenesis With Integrative Cancer Therapies

Natural health products that inhibit tumoral angiogenesis

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