The inhibitory effect of polysaccharides isolated from Phellinus linteus on tumor growth and metastasis

Han, Sang Bae; Lee, Chang Woo; Jeon, Young Jin; Hong, Nam Doo; Yoo, Ick Dong; Yang, Kyu Hwan; Kim, Hwan Mook

doi:10.1016/s0162-3109(98)00063-0

Cited by 228 publications

(140 citation statements)

References 18 publications

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“…Phellinsin A was able to inhibit the growth of fungi such as Colleotrichum lagenarium, Pyricularia oryzae, Rhizoctonia solani, Aspergillus fumigatus and Trichophyton mentagrophytes (Hwang et al 2000). Several studies have showed that Phellinus species can produce substances with cytotoxic (Atsumi et al 1990, 1993, Withers & Umezawa 1991, Han et al 1999, immunomodulatory (Song et al 1995, Kim et al 1996, antiviral (Walder et al 1995), antioxidant, antihepatotoxic (Ajith & Janardhnan 2002) activities.…”

Section: Resultsmentioning

confidence: 99%

Screening of Brazilian basidiomycetes for antimicrobial activity

Rosa

Machado

Jacob

et al. 2003

Mem. Inst. Oswaldo Cruz

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Section: Resultsmentioning

confidence: 99%

Screening of Brazilian basidiomycetes for antimicrobial activity

Rosa

Machado

Jacob

et al. 2003

Mem. Inst. Oswaldo Cruz

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“…In the last few decades, studies undertaken on polysaccharides isolated from natural sources have received considerable attention for their potential role as 'biological response modifiers', in terms of immunomodulatory and anti-tumor effects (Han et al, 1999;Ooi & Liu, 2000). The A. colubrina is a complex branched high-arabinose heteropolysaccharide that forms an aqueous solution of low viscosity (Delgobo et al, 1998).…”

Section: Anadenanthera Colubrina (Vell) Brenan Fabaceae (Angico-bramentioning

confidence: 99%

Bioactivity and potential therapeutic benefits of some medicinal plants from the Caatinga (semi-arid) vegetation of Northeast Brazil: a review of the literature

Silva¹,

Melo²,

Vasconcelos³

et al. 2012

Rev. bras. farmacogn.

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Abstract:Medicinal plants have been used in traditional medicine for several thousand years all over the world. In this sense, information from Brazilian ethnic groups on folk medicine have contributed to the discovery of pharmacological activities from various plant-derived agents potentially leading to the innovative drugs. The Caatinga (semi-arid) vegetation is a highly threatened biome, covering a vast area in northeastern Brazil and has suffered from strong human influence for many decades. Many plants species found in the Caatinga have been widely used in folk medicine and for commercial manufacturing of phytotherapeutic products. Thus, the present review aims to disseminate to the scientific community some known species of medicinal plants found in the Caatinga that have been studied and analyzed in pharmacological scientific assays. Among the species that stood out for their local importance and multiplicity of uses were: Amburana cearensisand Zingiber officinalis L. (gengibre). The present study shows that several herbal constituents from Caatinga plants, whose pharmacological actions have been well characterized, may be relevant candidates for future and innovative therapeutic development.

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“…PL, after purification, shows a relatively homogeneous molecular weight distribution on gel permeation HPLC and is estimated to be around 150 kDa from the retention time on HPLC pullulan molecular markers (Song et al, 1995). The main components of PL are polysaccharides (Song et al, 1995;Lorenzen and Anke, 1998;Borchers et al, 1999;Han et al, 1999). Many studies demonstrated that polysaccharides from various substances, including PL, are remarkably effective in inhibiting the growth of tumours without toxic side effects.…”

mentioning

confidence: 99%

Phellinus linteus activates different pathways to induce apoptosis in prostate cancer cells

et al. 2007

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It is known that polysaccharides extracted from the Phellinus linteus (PL) mushroom possess antitumour activity. We previously have demonstrated that high doses of PL render murine or human lung cancer cells susceptible to apoptosis. However, the molecular mechanisms of PL-mediated apoptosis have not been fully explored. In this study, we demonstrate that LNCaP cells expressing the androgen receptor (AR) are highly susceptible to apoptosis in response to treatment with high doses of PL. In this process, caspase 8 and its downstream effectors (such as BID), as well as ER stress-related, apoptotic signalling, are activated. In contrast, a moderate amount of apoptosis occurs in PC3 cells (that lack AR) after the same treatment, which does not activate ER-mediated apoptotic signalling. We also show that, in the process of PL-induced apoptosis, caspase 2 is induced in LNCaP cells, but not in PC3 cells. However, LNCaP cells that express a mutated AR or LNCaP cells treated with a caspase 2 inhibitor blocked ER stress-induced apoptotic signals. The magnitudes of the induction of apoptosis in these cells are comparable with what occurred in the PC3 cells. The data demonstrate that high doses of PL activate the AR-dependent and independent apoptotic pathways. Our study also suggests that caspase 2 is a key target in the determination of the susceptibility of prostate cancer cells to PL-induced apoptosis. Phellinus linteus (PL) is among a number of well-known medicinal mushrooms from Asian countries, which have been taken orally since ancient times as a health-promoting dietary supplement and an adjuvant to combat viral and bacterial infections. PL, after purification, shows a relatively homogeneous molecular weight distribution on gel permeation HPLC and is estimated to be around 150 kDa from the retention time on HPLC pullulan molecular markers (Song et al, 1995). The main components of PL are polysaccharides (Song et al, 1995;Lorenzen and Anke, 1998;Borchers et al, 1999;Han et al, 1999). Many studies demonstrated that polysaccharides from various substances, including PL, are remarkably effective in inhibiting the growth of tumours without toxic side effects. Studies also showed that polysaccharides in PL are able to suppress tumours, either indirectly by enhancing the host's immune system or directly by inducing apoptosis in tumour cells (Chihara et al, 1969;Chung et al, 1982;Cun et al, 1994;Wasser, 2002;Collins et al, 2006;Guo et al, 2006). Therefore, the antitumour, antiangiogenic and immunomodulatory effects of PL are potential areas for developing novel pharmaceutical products. However, the underlying molecular mechanisms of the antitumour effects of PL have not yet been fully explored.Changes in the androgen receptor (AR) have been indicated to contribute to the development of prostate cancer and are a serious challenge to effective treatment. Mutations in the AR can increase its affinity for ligand binding, permitting activation by nonandrogenic hormones or even antagonists (Nelson et al, 2003;Debes and Tindall, ...

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The inhibitory effect of polysaccharides isolated from Phellinus linteus on tumor growth and metastasis

Cited by 228 publications

References 18 publications

Screening of Brazilian basidiomycetes for antimicrobial activity

Screening of Brazilian basidiomycetes for antimicrobial activity

Bioactivity and potential therapeutic benefits of some medicinal plants from the Caatinga (semi-arid) vegetation of Northeast Brazil: a review of the literature

Phellinus linteus activates different pathways to induce apoptosis in prostate cancer cells

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